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Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Open accessAbstract
Incorporation of dioleoyl N‐(monomethoxy polyethyleneglycol succinyl)phosphotidylethanolamine (PEG‐PE) into large unilamellar liposomes composed of egg posphatidylcholine:cholesterol (1:1) does not significantly increase the content leakage when the liposomes are exposed to 90% human serum at 37°C, yet the liposomes show a significant increase in the blood circulation half‐life (t = 5 h) as compared to those without PEG‐PE(t <30 min). The PEG‐PE's activity to prolong the circulation time of liposomes is greater than that of the ganglioside GM 1, awell‐described glycolipid with this activity. Another amphipathic PEG derivative, PEG stearate, also prolongs the liposome circulation time, although its activity is less than that ofGM 1. Amphipathic PEGs may be useful for the sustained release and the targeted drug delivery by liposomes.
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Cited by
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Doxil® — The first FDA-approved nano-drug: Lessons learned
Barenholz, Y. (. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.020 · Cited by 4,792
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Strategies in the design of nanoparticles for therapeutic applications
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Metadata
- Authors
- Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1990-07-30
- Volume
- 268
- Issue
- 1
- Pages
- 235-237
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1970239046
- Cited by
- 2,027
- References
- 0
- FWCI
- 28.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990). Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Letters. https://doi.org/10.1016/0014-5793(90)81016-h
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