The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Effect of Lactobacillus plantarum 299v on Colonic Fermentation and Symptoms of Irritable Bowel Syndrome
Abstract
A number of recent clinical trials have promoted the use of probiotic bacteria as a treatment for irritable bowel syndrome (IBS). The recent demonstration of abnormal colonic fermentation in some patients with this condition provides an opportunity for the objective assessment of the therapeutic value of these bacteria. This study was designed to investigate the effects of Lactobacillus plantarum 299V on colonic fermentation. We conducted a double-blind, placebo-controlled, cross-over, four-week trial of Lactobacillus plantarum 299V in 12 previously untreated patients with IBS. Symptoms were assessed daily by a validated composite score and fermentation by 24-hr indirect calorimetry in a 1.4-m3 canopy followed by breath hydrogen determination for 3 hr after 20 ml of lactulose. On placebo, the median symptom score was 8.5 [6.25-11.25 interquartile range (IQR)], the median maximum rate of gas production was 0.55 ml/min (0.4-1.1 IQR), and the median hydrogen production was 189.7 ml/24 hr (118.3-291.1 IQR). On Lactobacillus plantarum 299V the median symptom score was 8 (6.75-13.5 IQR), the median maximum rate of gas production 0.92 ml/min (0.45-1.5 IQR), and the median hydrogen production 208.2 ml/24 hr (146-350.9 IQR). There was no significant difference. Breath hydrogen excretion after lactulose was reduced by the probiotic (median at 120 min, 6 ppm; placebo, 17 ppm; P = 0.019). In conclusion, Lactobacillus plantarum 299V in this study did not appear to alter colonic fermentati…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Two studies reported no difference between specific probiotic treatments and placebo,28–37 and one study reported a significant worsening of diarrhoea with the specific probiotic treatment compared with placebo.59”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
In the citing paper
“Twelve studies evaluated abdominal pain as a secondary end point only. Results from these studies were mixed: one reported a negative effect of the specific probiotic treatment,59 eight (examining six different probiotics) reported no significant effect28–38 and three reported a significant beneficial effect of three different probiotics35,39”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
In the citing paper
“all three studies that examined flatus as a primary end point,30,57 and four of seven studies in which flatus was a secondary end point only,28–38 showed no significant difference between seven specific probiotic treatments and control.”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
In the citing paper
“Probiotics tested to date do not help reduce flatus in patients with IBS Low [147,149-150,156,168,174-175, 178-179,184]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [178]
Citations
Cites
Predicting basal metabolic rate, new standards and review of previous work.
Wn, S. (1985) · PubMed · Cited by 2,911
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485
A double‐blind, placebo‐controlled trial
Pinals, R. S., Kaplan, S. B., Lawson, J. G., & Hepburn, B. (1986) · Arthritis & Rheumatism · doi:10.1002/art.1780291202 · Cited by 1,355
Nobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653
Guarner, F. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(97)00136-0 · Cited by 638
Alander, M., Satokari, R. M., Korpela, R., Saxelin, M., Vilpponen-Salmela, T., Mattila, T., & von Wright, A. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.1.351-354.1999 · Cited by 526
Abnormal colonic fermentation in irritable bowel syndrome
King, T. S., Elia, M., & Hunter, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02146-1 · Cited by 473
Self-citationIncreased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study
Rodríguez, L. A. G., & Ruigómez, A. (1999) · British medical journal · doi:10.1136/bmj.318.7183.565 · Cited by 409
Controlled treatment trials in the irritable bowel syndrome: A critique
Klein, K. B. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90319-8 · Cited by 381
Research works printed but not linked: 3
- Bayliss CE, Houston AP, Alun-Jones V, et al: Microbiological studies on food intolerance. Proc Nutr Soc 43:16A, 1984
- King TS, Hunter JO: Do symptoms improve with quality of life in IBS? Gut 40(suppl 1):64, 1997(abstract)
- Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA: Functional bowel disease and functional abdominal pain. Gut 45(suppl II):1143–1147, 1999
Cited by
Sorted by citations
Items 201–245 of 245
Alam, M., Abbas, K., Khan, M., Saini, R. S., & Faraz, M. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02317-8 · Cited by 2
Young, R. J., & Vanderhoof, J. A. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-183-7_11 · Cited by 2
Nutritional Aspects of Yogurt and Functional Dairy Products
Chryssanthopoulos, C., & Maridaki, M. D. (2009) · CRC Press eBooks · doi:10.1201/9781420082081-c9 · Cited by 3
Artificial cells for oral delivery of live bacterial cells for therapy
Prakash, S., Bhathena, J., & Urbanska, A. M. (2007) · Elsevier eBooks · doi:10.1533/9781845693077.3.189 · Cited by 2
A Study on the Usage of Probiotics as a Safer Antipyretic
Shrivastava, S., & Bhatu, N. (2023) · Journal of Cellular Signaling · doi:10.33696/signaling.4.093 · Cited by 2
Importance of the Microbiota in Early Life and Influence on Future Health
Collins, J. M., Cryan, J. F., & O’Mahony, S. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00017-5 · Cited by 2
An Overview of Probiotic Research
Ζουμποπούλου, Γ., Tsakalidou, E., & Thomas, L. V. (2017) · Wiley eBooks · doi:10.1002/9781119214137.ch8 · Cited by 3
Huertas‐Ceballos, A., Logan, S., Bennett, C., & Macarthur, C. (2010) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.544 · Cited by 1
Gut Microbiome and Gastrointestinal Disorders
Legaki, E., Karanasou, E. A., & Gazouli, M. (2021) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-59642-2_3 · Cited by 2
The Intestinal Microbiota and Intestinal Disease: Irritable Bowel Syndrome
Keren, N., & Gophna, U. (2011) · Springer eBooks · doi:10.1007/978-3-642-21680-0_15 · Cited by 1
Loo, M. (2009) · Elsevier eBooks · doi:10.1016/b978-141602299-2.10007-6 · Cited by 1
Irritable bowel syndrome: Bacteria and inflammation—Clinical relevance now
Spiller, R. E. (2007) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-007-0034-1 · Cited by 1
Irritable bowel syndrome dietary management
Staudacher, H. M., & Parkes, G. C. (2014) · Wiley eBooks · doi:10.1002/9781118872796.ch3.19 · Cited by 1
Nutrition and Hollow Organs of Lower Gastrointestinal Tract
Mutlu, E., Mobarhan, S., & Mutlu, G. (2007) · CRC Press eBooks · doi:10.1201/9781420008890-66 · Cited by 1
Halliez, M. C. M. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27133 · Cited by 1
Functional dairy products for gastrointestinal infections and dysfunction
Myllyluoma, E., Kajander, K., & Saxelin, M. (2007) · Elsevier eBooks · doi:10.1533/9781845693107.1.63 · Cited by 1
Syndrome de l’intestin irritable : rôle de la flore et intérêt potentiel des probiotiques
Ducrotte, P. R. (2007) · Côlon & Rectum · doi:10.1007/s11725-007-0062-8 · Cited by 1
Cucchiara, S., & Aloi, M. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-289-6_3
Functional Gastrointestinal Disorders in Adults
Quigley, E. M. M. (2013) · World review of nutrition and dietetics · doi:10.1159/000347200
Microarray Analysis of Probiotics Effectiveness
Carey, C. M., & Kostrzynska, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374938-3.00028-1 · Cited by 1
Rola szczepu Lactobacillus plantarum 299v w zapobieganiu i leczeniu zaburzeń układu pokarmowego
Wołkowicz, A., & Hozyasz, K. K. (2013) · Pediatria Polska · doi:10.1016/j.pepo.2013.04.002
[Irritable bowel syndrome: a functional disorder?].
Man, F., & Fernández, L. M. B. (2013) · PubMed
Probiotics, with special emphasis on their role in the management of irritable bowel syndrome
Stevenson, C., & Blaauw, R. (2012) · Pharmacy management
Probiotika bei Reizdarmsyndrom
Krammer, H., & Bluhm, M. (2012) · Pharmazie in unserer Zeit · doi:10.1002/pauz.201100461
Neuroimmunomodulation, Stress–Nutrition Interactions and Diet
Marín, J. R., Wärnberǵ, J., Nova, E., Gómez-Martínez, S., Díaz, L. E., Veses, A. M., & Marcos, A. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-061-8_5
The benefits of probiotics in irritable bowel syndrome
Emmanuel, A. V. (2013) · Gastrointestinal Nursing · doi:10.12968/gasn.2013.11.4.21
Probioticsevidence of their eff ectiveness
Reid, G., & Hammond, M. J.-A. (2005)
Urgesi, R., Casale, C., Pistelli, R., & Vitis, I. D. (2014)
Manzano, A., Estupiñán, G. D., & Poveda, E. (2012)
Probiotics in the treatment of the irritable bowel syndrome
de Paula, I., Theophilo, P., & Guimarães, N. G. (2008) · Cited by 2
Ingesson, M., & Wellander, A. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Application of Functional Dairy Products from IBS to IBD
Karakan, T. (2009) · CRC Press eBooks · doi:10.1201/9781420082081-c13
Effek van probiotika op die simptome en immunoglobulienvlakke van prikkelbare dermsindroom
Viljoen, M., Panzer, A., Koorts, A. M., Henn, P., & van den Bogaerde, J. (2004) · UpSpace Institutional Repository (University of Pretoria)
haq, M.-U., Ullah, F., Hassan, M., Babar, A. N., & Ullah, A. (2020) · Research Square · doi:10.21203/rs.2.23376/v2
Nutrition and Hollow Organs of Lower Gastrointestinal Tract
Mutlu, E., Mobarhan, S., & Mutlu, G. M. (2007) · CRC Press eBooks · doi:10.1201/9781420008890.ch61
haq, M.-U., Ullah, F., Hassan, M., Babar, A. N., & Ullah, A. (2020) · Research Square · doi:10.21203/rs.2.23376/v1
The benefits of probiotics in irritable bowel syndrome
Emmanuel, A. V. (2008) · Gastrointestinal Nursing · doi:10.12968/gasn.2008.6.3.29126
Khosruzzaman, S. M., Ishaque, S. M., Ahmed, D. S., Kabir, M. A., Ahmed, E. U., & Jannat, S. N. E. (2017) · Journal of Chittagong Medical College Teachers Association · doi:10.3329/jcmcta.v27i2.62362
Ait-Belgnaoui, A. (2006) · OpenGrey (Institut de l'Information Scientifique et Technique)
The effect of a prebiotic with a probiotic on symptoms and quality of life in ulcerative colitis
Haskey, N. (2007) · University Library - University of Saskatchewan (University of Saskatchewan)
Metadata
- Authors
- Sen, S., Mullan, M. M., Parker, T. J., Woolner, J. T., Tarry, S. A., & Hunter, J. O.
- Affiliations
- Addenbrooke's Hospital (GB)
- ORCID
- Parker, T.J.
- Venue
- Digestive Diseases and Sciences
- Published
- 2002-11
- Volume
- 47
- Issue
- 11
- Pages
- 2615-2620
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2059455849
- Cited by
- 245
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 2 · 2014: 16 · 2013: 12 · 2012: 17
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lunds Universitet
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus plantarum 299v, irritable bowel syndrome, probiotics, colonic fermentation, breath hydrogen, lactulose breath test, gas production, IBS symptoms, indirect calorimetry
- MeSH terms
- Adult, Breath Tests, Calorimetry, Indirect, Colon, Colonic Diseases, Functional, Double-Blind Method, Female, Fermentation, Humans, Hydrogen, Lactobacillus, Male, Middle Aged, Avena, Cross-Over Studies, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
