Cited by 199Schizophrenia research and treatmentNeurogenesis and neuroplasticity mechanismsMental Health and Psychiatry

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Molecular and Cellular Evidence for an Oligodendrocyte Abnormality in Schizophrenia

Hof, Patrick R., Haroutunian, Vahram, Copland, Christina, Davis, Kenneth L., Buxbaum, Joseph D.·2002·Neurochemical Research

DOI 10.1023/a:1020981510759

Open this paper in CoChat — free account

Abstract

Our previous analyses in postmortem prefrontal cortex samples from a well-characterized cohort of severely affected schizophrenics and in matched controls demonstrated decreased expression of myelin and oligodendrocyte-related genes in the disease state. This decreased expression, now replicated in independent studies, suggests that there is a disruption of oligodendrocyte function and/or a loss of oligodendrocytes in schizophrenia. In the current report, we review expression studies in schizophrenia and present data demonstrating consistently fewer oligodendrocytes in schizophrenics compared to controls. The decrease in density reached 22% (p < 0.01) in layer III of area 9 and 20% (p < 0.02) in the white matter of the superior frontal gyrus. These data, when taken together with expression studies carried out by us and by other groups, and by imaging and other microscopic studies, point to a major involvement of oligodendrocyte abnormalities in schizophrenia. Therapies modulating oligodendrocyte survival and differentiation may therefore be beneficial in schizophrenia.

Integrity signals

Registry

Crossref · 10.1023/a:1020981510759

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192
Self-citation
Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex
Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00085-4 · Cited by 882
Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia
Goldman-Rakic, P. S., & Selemon, L. D. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.437 · Cited by 668
Electron microscopy of oligodendroglia in severe mental illness
Uranova, N., Orlovskaya, D., Vikhreva, O., Zimina, I., Kolomeets, N., Vostrikov, V., & Rachmanova, V. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00528-7 · Cited by 495
Myelination of Cortical-hippocampal Relays During Late Adolescence
Benes, F. M. (1989) · Schizophrenia Bulletin · doi:10.1093/schbul/15.4.585 · Cited by 448
Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging
Lim, K. O., Hedehus, M., Moseley, M. E., de Crespigny, A. J., Sullivan, E. V., & Pfefferbaum, A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.367 · Cited by 447
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
Mirnics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A., & Levitt, P. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000866 · Cited by 446
Gene Expression Profiling Reveals Alterations of Specific Metabolic Pathways in Schizophrenia
Middleton, F. A., Mirnics, K., Pierri, J. N., Lewis, D. A., & Levitt, P. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02718.2002 · Cited by 425

Flagged first, then by citations

Show all 24 references

Research works printed but not linked: 1

Copland, C., Dracheva, S., Davis, K. L., and Haroutunian, V. 2002. mRNA expression of three isoforms of myelin associated glycoprotein (MAG) in patients with schizophrenia. Soc. Neurosci. Abs., in press.

Sorted by citations

Items 101–199 of 199

Abnormal Trajectory of Intracortical Myelination in Schizophrenia Implicates White Matter in Disease Pathophysiology and the Therapeutic Mechanism of Action of Antipsychotics
Tishler, T. A., Bartzokis, G., Lu, P. H., Raven, E. P., Khanoyan, M., Kirkpatrick, C. J., Pyle, M., Villablanca, J. P., Altshuler, L. L., Mintz, J., et al. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.03.007 · Cited by 36
MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia
Tunc‐Skarka, N., Weber‐Fahr, W., Hoerst, M., Meyer‐Lindenberg, A., Zink, M., & Ende, G. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.061 · Cited by 34
Microvessel length density, total length, and length per neuron in five subcortical regions in schizophrenia
Kreczmański, P., Heinsen, H., Mantua, V., Woltersdorf, F., Masson, T., Ulfig, N., Schmidt‐Kastner, R., Korr, H., Steinbusch, H. W. M., Hof, P. R., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0482-7 · Cited by 33
Self-citation
Reduced Intracortical Myelination in Schizophrenia
Bartzokis, G., & Altshuler, L. L. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1229-a · Cited by 32
Phencyclidine-induced changes in rat cortical gene expression identified by microarray analysis: implications for schizophrenia
Kaiser, S., Foltz, L., George, C., Kirkwood, S. C., Bemis, K. G., Lin, X., Gelbert, L. M., & Nisenbaum, L. K. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.011 · Cited by 31
Olanzapine stimulates proliferation but inhibits differentiation in rat oligodendrocyte precursor cell cultures
Kimoto, S., Okuda, A., Toritsuka, M., Yamauchi, T., Makinodan, M., Okuda, H., Tatsumi, K., Nakamura, Y., Wanaka, A., & Kishimoto, T. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.07.011 · Cited by 29
Influence of the entorhinal cortex on accumbal and striatal dopaminergic responses in a latent inhibition paradigm
Jeanblanc, J., Peterschmitt, Y., Hoeltzel, A., & Louilot, A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.022 · Cited by 29
The role of white matter for the pathophysiology of schizophrenia
Brambilla, P., & Tansella, M. (2007) · International Review of Psychiatry · doi:10.1080/09540260701500975 · Cited by 28
Increased Density of Prohibitin-Immunoreactive Oligodendrocytes in the Dorsolateral Prefrontal White Matter of Subjects with Schizophrenia Suggests Extraneuronal Roles for the Protein in the Disease
Bernstein, H., Smalla, K., Dürrschmidt, D., Keilhoff, G., Dobrowolny, H., Steiner, J. H., Schmitt, A., Kreutz, M. R., & Bogerts, B. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8185-y · Cited by 28
Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity
Komatsu, H., Takeuchi, H., Kikuchi, Y., Ono, C., Yu, Z., Iizuka, K., Takano, Y., Kakuto, Y., Funakoshi, S., Ono, T., et al. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa049 · Cited by 27
Progenitor cell-based treatment of glial disease
Goldman, S. A. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2017.02.010 · Cited by 25
DNA Microarray Analysis of Postmortem Brain Tissue
Mirnics, K., Levitt, P. R., & Lewis, D. A. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)60006-7 · Cited by 26
Quantitative Proton MR Spectroscopy Findings in the Corpus Callosum of Patients with Schizophrenia Suggest Callosal Disconnection
Aydın, K., Ucok, A., & Cakir, S. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0691 · Cited by 25
Fiber tracking of white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex in schizophrenia: A diffusion tensor imaging study
Kito, S., Jung, J., Kobayashi, T., & Koga, Y. (2009) · European Psychiatry · doi:10.1016/j.eurpsy.2008.12.012 · Cited by 23
Is Brain Banking of Psychiatric Cases Valuable for Neurobiological Research?
Schmitt, A., Parlapani, E., Bauer, M., Heinsen, H., & Falkai, P. (2008) · Clinics · doi:10.1590/s1807-59322008000200015 · Cited by 22
Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study
Palaniyappan, L. K., Al‐Radaideh, A., Mougin, O. E., Das, T., Gowland, P. A., & Liddle, P. F. (2018) · Psychological Medicine · doi:10.1017/s0033291718002647 · Cited by 22
Dopamine–glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia
Brisch, R., Bernstein, H., Krell, D., Dobrowolny, H., Bielau, H., Steiner, J. H., Gos, T., Funke, S., Stauch, R., Knüppel, S., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.039 · Cited by 22
Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population
Qu, M., Yue, W., Tang, F., Wang, L., Han, Y., & Zhang, D. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.10.005 · Cited by 22
Volumetric, relaxometric and diffusometric correlates of psychotic experiences in a non-clinical sample of young adults
Drakesmith, M., Dutt, A., Fonville, L., Zammit, S., Reichenberg, A., Evans, J., McGuire, P. K., Lewis, G., Jones, D. K., & David, A. S. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.09.002 · Cited by 21
Neuroanatomical changes in the adult rat brain after neonatal lesion of the medial prefrontal cortex
Klein, S., Koch, M., & Schwabe, K. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.09.015 · Cited by 21
Impairments of Motor-Cortex Responses to Unilateral and Bilateral Direct Current Stimulation in Schizophrenia
Hasan, A., Bergener, T., Nitsche, M. A., Strube, W., Bunse, T., Falkai, P., & Wobrock, T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00121 · Cited by 21
Fear Deficits in HypomyelinatedTpppKnock-Out Mice
Nguyen, H., Meservey, L. M., Ishiko, N., Zhou, M., Huang, T., & Fu, M. (2020) · eNeuro · doi:10.1523/eneuro.0170-20.2020 · Cited by 20
Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia
Bernstein, H., Jauch, E., Dobrowolny, H., Mawrin, C., Steiner, J., & Bogerts, B. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0640-y · Cited by 18
Pathophysiology of Schizophrenia
Falkai, P., Schmitt, A., & Cannon, T. D. (2011) · Wiley eBooks · doi:10.1002/9780470978672.ch2 · Cited by 18
Association between cortical volume and gray-white matter contrast with second generation antipsychotic medication exposure in first episode male schizophrenia patients
Chwa, W. J., Tishler, T. A., Raymond, C., Tran, C., Anwar, F., Villablanca, J. P., Ventura, J., Subotnik, K. L., Nuechterlein, K. H., & Ellingson, B. M. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.03.073 · Cited by 18
Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus
Yamauchi, T., Tatsumi, K., Makinodan, M., Kimoto, S., Toritsuka, M., Okuda, H., Kishimoto, T., & Wanaka, A. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.07.003 · Cited by 18
The 2′,3′-cyclic nucleotide 3′-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population
Usui, H., Takahashi, N., Saito, S., Ishihara, R., Aoyama, N., Ikeda, M., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., et al. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.07.019 · Cited by 18
Axonal myelin increase in the callosal genu in depression but not schizophrenia
Williams, M. R., Sharma, P., Fung, K. L., Pearce, R. K. B., Hirsch, S. R., & Maier, M. (2015) · Psychological Medicine · doi:10.1017/s0033291715000136 · Cited by 17
No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis
Che, R., Tang, W., Zhang, J., Wei, Z., Zhang, Z., Huang, K., Zhao, X., Gao, J., Zhou, G., Huang, P., et al. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-31 · Cited by 17
Abnormalities in oligodendrocyte clusters in the inferior parietal cortex in schizophrenia are associated with insight
Kolomeets, N. S., Vm, V., & Uranova, N. A. (2013) · The European Journal of Psychiatry · doi:10.4321/s0213-61632013000400003 · Cited by 17
Functional and white matter abnormalities in the language network in patients with schizophrenia: A combined study with diffusion tensor imaging and functional magnetic resonance imaging
Leroux, E., Delcroix, N., Alary, M., Razafimandimby, A., Brazo, P., Delamillieure, P., & Dollfus, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.016 · Cited by 18
Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia
Krystal, J. H., & Moghaddam, B. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch21 · Cited by 17
Geissoschizine Methyl Ether, an Alkaloid from the Uncaria Hook, Improves Remyelination After Cuprizone-Induced Demyelination in Medial Prefrontal Cortex of Adult Mice
Morita, S., Tatsumi, K., Makinodan, M., Okuda, H., Kishimoto, T., & Wanaka, A. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1190-1 · Cited by 16
Neonatal lesions of the entorhinal cortex induce long-term changes of limbic brain regions and maze learning deficits in adult rats
Harich, S., Kinfe, T. M., Koch, M., & Schwabe, K. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.017 · Cited by 16
Recombinant human IGF-1 for patients with schizophrenia
Khalil, R. B. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.001 · Cited by 14
A logical relationship for schizophrenia, bipolar, and major depressive disorder. Part 1: Evidence from chromosome 1 high density association screen
Zhang, Z., & Chen, G. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24921 · Cited by 13
Elevated levels of Insulin-like Growth Factor-1 (IGF-1) in drug-naïve patients with psychosis
Petrikis, P., Boumba, V. A., Tzallas, A. T., Voulgari, P. V., Archimandriti, D. T., Skapinakis, P., & Mavreas, V. G. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.09.053 · Cited by 15
Advancements in the Underlying Pathogenesis of Schizophrenia: Implications of DNA Methylation in Glial Cells
Chen, X., Huang, N., Namaka, M., & Xiao, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00451 · Cited by 13
White matter volume change and its correlation with symptom severity in patients with schizophrenia
Kim, G.-W., & Jeong, G. (2015) · Neuroreport · doi:10.1097/wnr.0000000000000471 · Cited by 13
Mean kurtosis alterations of cerebral white matter in patients with schizophrenia revealed by diffusion kurtosis imaging
Narita, H., Tha, K. K., Hashimoto, N., Hamaguchi, H., Nakagawa, S., Shirato, H., & Kusumi, I. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.07.011 · Cited by 12
The neurobiology of transition to psychosis: clearing the cache
Palaniyappan, L. K., Das, T., & Dempster, K. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170137 · Cited by 12
Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis
Schoonover, K. E., Farmer, C. B., Morgan, C. J., Sinha, V., Odom, L. B., & Roberts, R. C. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2020.12.016 · Cited by 10
Insights into myelin dysfunction in schizophrenia and bipolar disorder
Valdés‐Tovar, M., Rodríguez‐Ramírez, A. M., Rodríguez-Cárdenas, L., Sotelo-Ramírez, C. E., Camarena, B., Sanabrais‐Jiménez, M. A., Solís‐Chagoyán, H., Argueta, J., & López-Riquelme, G. O. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i2.268 · Cited by 11
Exploring the Hypothesis of a Schizophrenia and Bipolar Disorder Continuum: Biological, Genetic and Pharmacologic Data
de Sousa, T. R., Correia, D. T., & Novais, F. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210902164235 · Cited by 10
Role of Redox Dysregulation in White Matter Anomalies Associated with Schizophrenia
Monin, A., Fournier, M., Baumann, P., Cuénod, M., & Kim, Q. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00028-6 · Cited by 10
Reduced Proliferation of Oligodendrocyte Progenitor Cells in the Postnatal Brain of Dystonia Musculorum Mice
Hossain, M. I., Horie, M., & Takebayashi, H. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2342-5 · Cited by 10
Myelination and Brain Electrophysiology in Healthy and Schizophrenic Individuals
Bartzokis, G. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300180 · Cited by 10
Psychosis and depression - a neurobiological view.
Pregelj, P. (2009) · PubMed · Cited by 9
Connections in Schizophrenia
Lim, K. O. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.7.995 · Cited by 9
Glial evolution as a determinant of human behavior and its disorders
Goldman, S. A. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14372 · Cited by 9
Age-related differences in axon pruning and myelination may alter neural signaling in autism spectrum disorder
Hanson, K. L., Avino, T. A., Taylor, S. L., Murray, K. D., & Schumann, C. M. (2025) · Molecular Autism · doi:10.1186/s13229-025-00684-y · Cited by 9
Progressive brain changes in schizophrenia: a 1-year follow-up study of diffusion tensor imaging
Ota, M., Obu, S., Sato, N., Mizukami, K., & Asada, T. (2009) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2009.00422.x · Cited by 7
Interactions between knockout of schizophrenia risk factor Dysbindin-1 and copper metabolism in mice
Schoonover, K. E., McMeekin, L. J., Farmer, C. B., Varghese, N. E., Queern, S. L., Lapi, S. E., Cowell, R. M., & Roberts, R. C. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.07.024 · Cited by 5
Psychiatry's Remarkable Journey: The Past 40 Years
Pardes, H. (2003) · Psychiatric Services · doi:10.1176/appi.ps.54.6.896 · Cited by 6
Synaptic Vesicle Associated Proteins and Schizophrenia
Kao, H., & Porton, B. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_7 · Cited by 6
A systematic review of the effect of genes mediating neurodevelopment and neurotransmission on brain morphology: Focus on schizophrenia
John, J. P., Thirunavukkarasu, P., Halahalli, H. N., Purushottam, M., & Jain, S. (2015) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2014.11.003 · Cited by 5
Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia
Smith, B. J., Brandão‐Teles, C., Zuccoli, G. S., Reis‐de‐Oliveira, G., Fioramonte, M., Saia-Cereda, V. M., & Martins‐de‐Souza, D. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091408 · Cited by 5
Funktionell-neuroanatomische und neuropathologische Grundlagen psychischer Erkrankungen
Bogerts, B. (2007) · Springer eBooks · doi:10.1007/978-3-540-33129-2_5 · Cited by 5
Estudos transcriptômicos no contexto da conectividade perturbada em esquizofrenia
Schmitt, A., Reich‐Erkelenz, D., Gebicke‐Haerter, P. J., & Falkai, P. (2012) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/s0101-60832012005000001 · Cited by 4
The Neuropathology of Schizophrenia: Central Role for the Hippocampus?
Falkai, P., Parlapani, E., Gruber, O., & Schmitt, A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0913-8_7 · Cited by 4
Blood and Brain Gene Expression in Major Psychiatric Disorders: A Search for Biomarkers
Chana, G., Glatt, S. J., Everall, I., & Tsuang, M. T. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_1 · Cited by 4
Neuregulin 1 and Schizophrenia
Chen, Y.-J. J., Role, L. W., & Talmage, D. A. (2009) · Springer eBooks · doi:10.1007/978-0-387-30410-6_6 · Cited by 3
The Neuropathology of White Matter in Schizophrenia
Uranova, N. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-68308-5_11 · Cited by 2
Bedeutung der Frontallappen für die Pathophysiologie schizophrener Erkrankungen
Bogertsc, B. (2005) · Springer eBooks · doi:10.1007/3-540-26841-3_10 · Cited by 2
Gene Expression Changes and Potential Impact of Endophenotypes in Major Psychiatric Disorders
Chana, G., Kwok, J., Glatt, S. J., Everall, I., & Tsuang, M. T. (2009) · Springer eBooks · doi:10.1007/978-90-481-2298-1_3 · Cited by 2
Нарушение кластеризации олигодендроцитов в нижней теменной коре при шизофрении: связь с возрастом к началу заболевания
Kolomeets, N. S., & Уранова, Н. А. (2015) · Psikhiatriya · doi:10.30629/2618-6667-2015-67-52-57 · Cited by 2
A hydrolyzed lipid blend diet promotes myelination in neonatal piglets in a region and concentration‐dependent manner
Louie, A. Y., Rund, L. A., Komiyama‐Kasai, K. A., Weisenberger, K. E., Stanke, K. L., Larsen, R. J., Leyshon, B. J., Kuchan, M. J., Das, T., & Steelman, A. J. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25243 · Cited by 1
Analyses of Disruption of Cerebral White Matter Integrity in Schizophrenia with MR Diffusion Tensor Fiber Tracking Method
Yamamoto, U., Kobayashi, T., Kito, S., & Koga, Y. (2010) · IEEJ Transactions on Electronics Information and Systems · doi:10.1541/ieejeiss.130.799 · Cited by 1
The neurobiology of schizophrenia
Harrison, P. J. (2012) · doi:10.1093/med/9780199696758.003.0077 · Cited by 2
Funktionell-neuroanatomische und neuropathologische Grundlagen psychischer Erkrankungen
Bogerts, B., & Walter, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_6 · Cited by 1
Lipogenic effects of antipsychotic drugs in cultured cells and in rat
Fernø, J. (2007) · NORA - Norwegian Open Research Archives
Glial loss in mood disorders and schizophrenia
Price, J. L. (2003) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(03)31047-1
Neurobiologische Grundlagen der Schizophrenie
Gruber, O., Falkai, P., & Schmitt, A. (2010) · Nervenheilkunde · doi:10.1055/s-0038-1628763
Proteomic Characterization of the Brain and Cerebrospinal Fluid of Schizophrenia Patients
Café-Mendes, C. C., Gattaz, W. F., Schmitt, A., Britto, L. R. G., & Martins‐de‐Souza, D. (2014) · Advances in biological psychiatry · doi:10.1159/000358021
Neurobiologie der Schizophrenien
Bogerts, B., & Steiner, J. H. (2009) · Psychiatrie und Psychotherapie up2date · doi:10.1055/s-0029-1220380
Advances in Oligoprotection
Liao, H., & Mani, D. S. (2011) · Neuroscience & Medicine · doi:10.4236/nm.2011.22014
High-resolution Studies of mRNA Expression in Brain A Search for Genes Differently Expressed in Schizophrenia
Castensson, A. (2003) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Neurobiologie der chronisch schizophrenen Erkrankungen: Progressive Enzephalopathie oder Störung der Neuroplastizität?
Schmitt, A., Wobrock, T., Gruber, O., & Falkai, P. (2010) · Journal für Kardiologie (Krause & Pachernegg GmbH)
Habilitationsschrift Mikrostrukturelle Gewebecharakterisierung durch Diffusion Tensor Imaging - neue Möglichkeiten in der radiologischen Diagnostik
Hamm, B. K. (2014)
ORIGINAL RESEARCH Quantitative Proton MR Spectroscopy Findings in the Corpus Callosum of Patients with Schizophrenia Suggest Callosal Disconnection
Aydın, K., Üçok, A., & Çakır, S. (2007)
Studies of the global gene expression changes in alcoholic human brain and blood
Liu, J. (2005) · Texas ScholarWorks (Texas Digital Library)
Schizophrenia and comorbid cannabis use disorders. Brain structure, function and the effect of antipsychotic medications
Machielsen, M. W. J. (2014) · UvA-DARE (University of Amsterdam)
Microarray Analysis of Lipid Metabolism in Drug Abuse, Neurological and Psychiatric Disorders
Lehrmann, E., Chen, J., Lee, C., Freed, W. J., & Becker, K. G. (2004) · CRC Press eBooks · doi:10.1201/9781420030921.ch9
Immunhistochemische Untersuchung von Oligodendrozyten im post- mortem Hippokampus bei Schizophrenie
Shariati, J. (2017) · doi:10.53846/goediss-6301
Патология олигодендроглии и когнитивные расстройства при шизофрении
Уранова, Н. А. (2017) · Psikhiatriya · doi:10.30629/2618-6667-2017-76-77-88
Hypomyelination of interneurons in the APO-SUS rat model for schizophrenia
Vugt, N. (2019)
Statins surpass SARS
(2003) · The Lancet · doi:10.1016/s0140-6736(03)14290-0
Frontal Cortex
Williams, M. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-68308-5_4
Schizophrene Störungen
Steiner, J. H., & Bogerts, B. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_30
Psychiatric Disorders
Priller, J. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199794591.003.0071
Faculty Opinions recommendation of Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.
Paola, V. D., & Khan, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727821479.793555736
Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome
Brandão‐Teles, C., Carregari, V. C., Reis‐de‐Oliveira, G., Smith, B. J., Chaves, Y. C., Santos, A. V. S., Pinheiro, E. M. D. C., Oliveira, C. C., Vieira, A. S., Crunfli, F., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16304
Role of Glial Cells in Neurodegenerative Diseases and Metals-Induced Neurotoxicity
Pajarillo, E. A. B., Nyarko‐Danquah, I., Digman, A., Kim, S., Ajayi, I., Aschner, M., & Lee, E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00227-8
Changes of fractional anisotropy of the cerebral white matter in first-episode schizophrenia
Slezák, O., Žižka, J., Škoch, A., Bayer, D., Španiel, F., Tintěra, J., Jandura, J., & Eliáš, P. (2018) · Česká radiologie · doi:10.55095/cesradiol2018/037
Myo-inositol concentration in the medial prefrontal cortex is associated with changes in brain white matter microstructure in early psychosis
Pavan, T., Wang, Q., Alemán‐Gómez, Y., Jenni, R., Cleusix, M., Alameda, L., Kim, Q., Conus, P., Hagmann, P., Steullet, P., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04072-9 · Cited by 1
Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia
Roy, C., & Corfas, G. (2007) · Springer eBooks · doi:10.1007/978-0-387-74351-6_4
Developing a rodent model for antipsychotic-induced metabolic adverse effects
Skrede, S. (2012) · NORA - Norwegian Open Research Archives
Unraveling myelin biogenesis: The hidden role in neuropsychiatric disorders
Valdez, K. G., Murambadoro, A. K., Punch, K. D., Martin, B. C., Mourao, N., Szobody, M. W., Gullapalli, S., Sayers, T., Baldado, L., Rodriguez, I. N., et al. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.10.029
Zaburzenia mielinizacji i migracji neuronalnej w patogenezie schizofrenii - poszukiwanie nowych genów kandydujących
Gawłowska-Sawosz, M., & Rabe‐Jabłońska, J. (2007) · Psychiatria i Psychologia Kliniczna

Authors: Hof, P. R., Haroutunian, V., Copland, C., Davis, K. L., & Buxbaum, J. D.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Buxbaum, Joseph D.
ORCID: Hof, Patrick R.
Haroutunian, Vahram
Copland, Christina
Davis, Kenneth L.
Buxbaum, Joseph D.
Venue: Neurochemical Research
Publisher: Springer Science and Business Media LLC
Published: 2002-10
Volume: 27
Issue: 10
Pages: 1193-1200
ISSN: 0364-3190 (ISSN-L)
1573-6903
DOI: 10.1023/a:1020981510759
OpenAlex: W132008894
Cited by: 199
References: 24
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 10 · 2016: 5 · 2015: 12 · 2014: 10 · 2013: 6 · 2012: 13
FWCI: 8.10
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Neurochemical Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01mh045212-05)
National Institute of Mental Health (MH 45212)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, oligodendrocytes, myelin, oligodendrocyte loss, prefrontal cortex, gene expression, white matter, superior frontal gyrus, oligodendrocyte differentiation, oligodendrocyte survival
MeSH terms: Aged, Aged, 80 and over, Brain, Cell Count, Female, Humans, Male, Oligodendroglia, Reference Values, Schizophrenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular and Cellular Evidence for an Oligodendrocyte Abnormality in Schizophrenia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks