The role of oligodendrocyte pathology in schizophrenia
Open accessAbstract
Neuroimaging and microarray studies provide evidence for myelin and oligodendrocyte abnormalities in schizophrenia (SZ). Electron microscopy demonstrated dystrophy, necrosis and apoptosis of oligodendrocytes, the most severely affected cells in SZ. The proportion of myelinated fibres with atrophy of axon and swelling of periaxonal oligodendrocyte processes increased significantly in the prefrontal cortex (PFC), caudate nucleus and hippocampus in SZ compared to controls. Morphometry showed a deficit of oligodendrocytes in the PFC and in adjacent white matter, lower number of oligodendroglial satellites of pyramidal neurons and a loss of pericapillar oligodendrocytes in the PFC in SZ compared to normal controls. A lowered number of oligodendrocytes in the PFC was also found in mood disorders. These data provide evidence for altered oligodendrocyte-axon, oligodendrocyte-neuron and oligodendrocyte-capillar interactions in SZ brains suggesting a key role of damage and loss of oligodendrocytes in altered neuronal connectivity and in atrophy of neurons in SZ.
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Patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.
“After more than 2 decades of neuroimaging research, it is now well established that patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [19]
Schizophrenia patients exhibit myelin-specific abnormalities including reduced numbers of oligodendrocytes, irregular myelin microstructure, and subnormal expression of myelin-related genes.
“When combined with the fact that schizophrenia patients exhibit a range of myelin-specific abnormalities-including reduced numbers of oligodendrocytes, 19 irregular myelin microstructure, 20 and subnormal expression of myelin-related genes 44”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [19]
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Self-citation
- Authors
- Uranova, N. A., Vostrikov, V. M., Vikhreva, O. V., Zimina, I. S., Kolomeets, N. S., & Orlovskaya, D. D.
- Affiliations
- Mental Health Research Center of Russian Academy of Medical Sciences (RU)
- Corresponding author
- Uranova, Natalya A.
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02-21
- Volume
- 10
- Issue
- 04
- Pages
- 537
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2161900528
- Cited by
- 176
- References
- 56
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 10 · 2015: 10 · 2014: 14 · 2013: 13 · 2012: 10
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stanley Medical Research Institute
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, myelin abnormalities, oligodendrocyte apoptosis, prefrontal cortex, white matter, neuronal atrophy, mood disorders, neuronal connectivity
- MeSH terms
- Atrophy, Brain, Cadaver, Caudate Nucleus, Hippocampus, Humans, Microscopy, Electron, Middle Aged, Myelin Sheath, Necrosis, Nerve Fibers, Myelinated, Oligodendroglia, Schizophrenia, Case-Control Studies, Apoptosis, Prefrontal Cortex
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