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Cited by 448Schizophrenia research and treatmentMedical and Biological SciencesNeurogenesis and neuroplasticity mechanisms

Myelination of Cortical-hippocampal Relays During Late Adolescence

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Benes, F. M.·1989·Schizophrenia Bulletin
DOI 10.1093/schbul/15.4.585
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Abstract

The normal developmental series of brains in the Yakovlev Collection has been examined to explore the possibility that various brain regions implicated in schizophrenia may show changes in myelination during late adolescence, a period coinciding with the appearance of early symptoms of this disorder. The prefrontal, cingulate, and parahippocampal (entorhinal) cortex, as well as the perforant pathway, cingulum bundle, and hippocampus, were closely examined because these regions have recently been found to show various neuropathological differences in schizophrenia. Observation of these specimens has confirmed earlier reports by Yakovlev and Lecours (1967) that primary motor and sensory cortices show robust myelination early in the first decade of life. In contrast, associative cortical areas show increased amounts of myelin staining only by the second decade, although some cortical areas, like the cingulate and basofrontal cortex, remain poorly myelinated throughout life. The most striking finding, however, was the appearance of increased myelination of the subicular and presubicular regions during the late adolescent period. Increased myelination in the subiculum was localized to a discrete region at the surface where fibers of the perforant pathway are known to aggregate as they course toward the area dentata. The comparable region in the adjacent presubicular area that also showed increased myelin staining probably contains distal portions of the cingulum bundle. Support for this latter possibility was obtained from a single case in which a stereotaxically placed lesion causing interruption of the cingulum bundle showed less myelin in the presubicular area of the effectively lesioned side.(ABSTRACT TRUNCATED AT 250 WORDS)

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  • Cerebral white matter increases in the first four decades because of axonal myelination and may partially explain the observed GM loss.

    “Cerebral white matter increases in the first four decades because of axonal myelination (40) and may partially explain the observed GM loss (41, 42).”

    From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [41]

    Citation (40) is attached to the claim about white matter and myelination, not the separate GM-loss claim. The Results and Discussion (page not available) describe increasing myelination in selected regions during development, but do not establish that cerebral white matter as a whole increases throughout the first four decades. The Discussion says this study failed to corroborate an earlier suggestion of continued prefrontal myelination through the fourth decade. (LLM, conf=0.84)

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Research works printed but not linked: 2

  1. Goldman, P.S. An alternative to developmental plasticity: Heterology of CNS structures in infants and adults. In: Stein, D.; Rosen, ].; and Butters, M., eds. Plasticity and Recovery of Function in the CNS. New York: Academic Press, 1974. pp. 149-174.
  2. Ramon Y Cajal, S. Histologi du Systeme Nerveux del Homme et du Vertebrates. Tome II. Madrid, Spain: Consejo Superior de Investigaciones Cientificos Instituto Ramon Y Cajal, 1911. pp. 772-779.

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Authors
Benes, F. M.
Affiliations
McLean Hospital (US)
Corresponding author
Benes, F. M.
ORCID
Benes, F. M.
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
1989-01-01
Volume
15
Issue
4
Pages
585-593
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/15.4.585
OpenAlex
W2118775806
Cited by
448
References
38
Citations by year
2026: 5 · 2025: 8 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 18 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 16 · 2015: 19 · 2014: 13 · 2013: 24 · 2012: 17
FWCI
20.23
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • McLean Hospital
  • U.S. Public Health Service (31154)
  • National Institute of Mental Health (MH-42261, MH00423, MH-31154)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
myelination
MeSH terms
Adolescent, Adult, Attention, Cerebral Cortex, Child, Child, Preschool, Frontal Lobe, Gyrus Cinguli, Hippocampus, Humans, Infant, Infant, Newborn, Middle Aged, Motivation, Myelin Sheath, Nerve Fibers, Myelinated, Neural Pathways, Reference Values, Temporal Lobe

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