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Cited by 46Proteoglycans and glycosaminoglycans researchCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Glycosaminoglycan-lipoprotein interaction

Olsson, Urban, Östergren-Lundén, Gunnel, Moses, Jonatan·2001·Glycoconjugate Journal
DOI 10.1023/a:1021155518464
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Abstract

Glycosaminoglycans (GAGs) bound to various proteoglycans (PGs) present in the cardiovascular system have been proposed to perform a wide range of functions. These include conferring viscoelastic properties; interacting with and modulating growth factors and enzymes; and as receptors and co-receptors in lipoprotein metabolism. Binding of apoB-100 lipoproteins, particularly low density lipoproteins (LDL), to GAGs of extracellular matrix PGs in arteries has been proposed to be an initiating event in development of atherosclerosis. This study was initiated with the aim of getting an overview of the binding patterns of different lipoprotein subclasses with individual GAG categories. We thus evaluated the interaction of lipoproteins with GAGs commonly found in the cardiovascular system using a gel mobility-shift assay developed for this purpose. The same procedure was used to measure lipoproteins binding to metabolically [(35)S]-labeled whole PGs prepared from three cell types, arterial smooth muscle cells, THP-1 macrophages and from HepG2 cells. The effect of GAG composition on PGs on lipoprotein binding was evaluated by enzymatic degradation of the carbohydrate chains. Heparan sulfate was found to bind beta very low density lipoproteins (beta-VLDL) and a chylomicron remnant model (beta-VLDL+apoE), but not LDL. Dermatan sulfate was found to bind LDL, but not beta-VLDL or the chylomicron remnant model. Chondroitin sulfate and heparin were found to bind all lipoproteins tested (LDL, beta-VLDL and beta-VLDL+apoE) although with different affinities. We can conclude that each lipoprotein subclass tested binds a specific assortment of the GAGs tested. The observations made contribute to the understanding of new and complex mechanisms by which carbohydrate and lipid metabolism may be linked.

Overview

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Crossref · 10.1023/a:1021155518464

Cites

41 of 41 references verified0 citation errors · 0 not checkable

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Citations

Cites

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Research works printed but not linked: 1

  1. Wight TN, The Vascular Extracellular Matrix (Lippincott Raven, Philadelphia, PA, 1996).

Cited by

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Related

Metadata

Authors
Olsson, U., Östergren-Lundén, G., & Moses, J.
Affiliations
Sahlgrenska University Hospital (SE)
Corresponding author
Olsson, Urban
Venue
Glycoconjugate Journal
Publisher
Springer Science and Business Media LLC
Published
2001-10
Volume
18
Issue
10
Pages
789-797
ISSN
  • 0282-0080 (ISSN-L)
  • 1573-4986
DOI
10.1023/a:1021155518464
OpenAlex
W1760442572
Cited by
46
References
41
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 3 · 2015: 1 · 2012: 1
FWCI
0.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Glycoconjugate Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • AstraZeneca
  • Vetenskapsrådet
  • Magnus Bergvalls Stiftelse
  • Socialstyrelsen
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
lipoprotein binding, heparan sulfate, dermatan sulfate, chondroitin sulfate, heparin, low-density lipoprotein, beta-VLDL, chylomicron remnants, apolipoprotein E, proteoglycans, atherosclerosis, lipoprotein metabolism, carbohydrate metabolism
MeSH terms
Autoradiography, Cardiovascular System, Glycosaminoglycans, Humans, Lipoproteins, Models, Biological, Protein Binding, Recombinant Proteins, Substrate Specificity, Sulfur Radioisotopes, Tumor Cells, Cultured, Electrophoretic Mobility Shift Assay

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Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.