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Cited by 129Cellular Mechanics and InteractionsProtease and Inhibitor MechanismsTGF-β signaling in diseases

Extracellular matrix dynamics in vascular remodeling

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Ma, Zihan, Mao, Chenfeng, Jia, Yiting, Fu, Yi, Kong, Wei·2020·American Journal of Physiology-Cell Physiology
DOI 10.1152/ajpcell.00147.2020PMC PMC7509265
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Abstract

Vascular remodeling is the adaptive response to various physiological and pathophysiological alterations that are closely related to aging and vascular diseases. Understanding the mechanistic regulation of vascular remodeling may be favorable for discovering potential therapeutic targets and strategies. The extracellular matrix (ECM), including matrix proteins and their degradative metalloproteases, serves as the main component of the microenvironment and exhibits dynamic changes during vascular remodeling. This process involves mainly the altered composition of matrix proteins, metalloprotease-mediated degradation, posttranslational modification of ECM proteins, and altered topographical features of the ECM. To date, adequate studies have demonstrated that ECM dynamics also play a critical role in vascular remodeling in various diseases. Here, we review these related studies, summarize how ECM dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.

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  • Vascular density and stability are strongly influenced by ECM composition.

    “Notably, vascular density and stability were strongly influenced by ECM composition 23 .”

    From Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro (2026) · cites this paper as [23]

    The Introduction (page unavailable) reports increased vascular density in TSP-2-knockout mice and says ECM components maintain endothelial integrity. It also links collagen composition to atherosclerotic plaque stability, but does not establish the broader claim that vascular stability is strongly influenced by ECM composition. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Ma, Z., Mao, C., Jia, Y., Fu, Y., & Kong, W.
Affiliations
Peking University (CN)
Corresponding author
Fu, Yi
ORCID
Venue
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Published
2020-09-01
Volume
319
Issue
3
Pages
C481-C499
ISSN
  • 0363-6143 (ISSN-L)
  • 1522-1563
DOI
10.1152/ajpcell.00147.2020
PMC
PMC7509265
OpenAlex
W3037400185
Cited by
129
References
5
Citations by year
2026: 16 · 2025: 26 · 2024: 20 · 2023: 27 · 2022: 26 · 2021: 12 · 2020: 2
FWCI
1.95
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Cell Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81730010, 91839302, 81922009, 91739116, 81921001, 31930056)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
vascular remodeling, extracellular matrix, matrix metalloproteinases, extracellular matrix degradation, post-translational modification, vascular disease, aging, biomarkers, therapeutic target
MeSH terms
Animals, Extracellular Matrix, Humans, Vascular Diseases, Biomarkers, Extracellular Matrix Proteins, Matrix Metalloproteinases, Vascular Remodeling

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