Cited by 481Proteoglycans and glycosaminoglycans researchOsteoarthritis Treatment and MechanismsCellular transport and secretion

Synthesis and sorting of proteoglycans

Prydz, Kristian, Dalen, Knut Tomas·2000·Journal of Cell Science

Abstract

Proteoglycans are widely expressed in animal cells. Interactions between negatively charged glycosaminoglycan chains and molecules such as growth factors are essential for differentiation of cells during development and maintenance of tissue organisation. We propose that glycosaminoglycan chains play a role in targeting of proteoglycans to their proper cellular or extracellular location. The variability seen in glycosaminoglycan chain structure from cell type to cell type, which is acquired by use of particular Ser-Gly sites in the protein core, might therefore be important for post-synthesis sorting. This links regulation of glycosaminoglycan synthesis to the post-Golgi fate of proteoglycans.

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Crossref · 10.1242/jcs.113.2.193

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173 of 173 references verified0 citation errors · 0 not checkable

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Authors
Prydz, K., & Dalen, K. T.
Affiliations
University of Oslo (NO)
Venue
Journal of Cell Science
Published
2000-01-15
Volume
113
Issue
2
Pages
193-205
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
OpenAlex
W1955765029
Cited by
481
References
173
Citations by year
2026: 3 · 2025: 10 · 2024: 9 · 2023: 20 · 2022: 27 · 2021: 18 · 2020: 21 · 2019: 11 · 2018: 11 · 2017: 19 · 2016: 21 · 2015: 18 · 2014: 21 · 2013: 22 · 2012: 27
FWCI
1.36
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cell Science (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
proteoglycans, glycosaminoglycans, post-Golgi trafficking, glycosaminoglycan synthesis, growth factor binding, extracellular matrix, cell differentiation
MeSH terms
Amino Acid Sequence, Animals, Carbohydrate Sequence, Chondroitin Sulfates, Dermatan Sulfate, Epithelial Cells, Glycosaminoglycans, Golgi Apparatus, Heparin, Heparan Sulfate, Humans, Molecular Sequence Data, Oligosaccharides, Proteoglycans, Cell Polarity

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