Synthesis and sorting of proteoglycans
Abstract
Proteoglycans are widely expressed in animal cells. Interactions between negatively charged glycosaminoglycan chains and molecules such as growth factors are essential for differentiation of cells during development and maintenance of tissue organisation. We propose that glycosaminoglycan chains play a role in targeting of proteoglycans to their proper cellular or extracellular location. The variability seen in glycosaminoglycan chain structure from cell type to cell type, which is acquired by use of particular Ser-Gly sites in the protein core, might therefore be important for post-synthesis sorting. This links regulation of glycosaminoglycan synthesis to the post-Golgi fate of proteoglycans.
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- Authors
- Prydz, K., & Dalen, K. T.
- Affiliations
- University of Oslo (NO)
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2000-01-15
- Volume
- 113
- Issue
- 2
- Pages
- 193-205
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1955765029
- Cited by
- 481
- References
- 173
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 9 · 2023: 20 · 2022: 27 · 2021: 18 · 2020: 21 · 2019: 11 · 2018: 11 · 2017: 19 · 2016: 21 · 2015: 18 · 2014: 21 · 2013: 22 · 2012: 27
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- proteoglycans, glycosaminoglycans, post-Golgi trafficking, glycosaminoglycan synthesis, growth factor binding, extracellular matrix, cell differentiation
- MeSH terms
- Amino Acid Sequence, Animals, Carbohydrate Sequence, Chondroitin Sulfates, Dermatan Sulfate, Epithelial Cells, Glycosaminoglycans, Golgi Apparatus, Heparin, Heparan Sulfate, Humans, Molecular Sequence Data, Oligosaccharides, Proteoglycans, Cell Polarity
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