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Cited by 202Animal Behavior and Welfare StudiesStress Responses and CortisolMemory and Neural Mechanisms

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Rearing Environmental Enrichment in Two Inbred Strains of Mice: 1. Effects on Emotional Reactivity

Chapillon, P., Manneché, C., Belzung, C., Caston, J.·1999·Behavior Genetics
DOI 10.1023/a:1021437905913
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Abstract

The effects of an enriched rearing environment on two types of anxiety-like behavior (designated "trait" and "state" anxiety) and on spontaneous activity were investigated in two inbred strains of mice, BALB/c (C) and C57BL/6(B6). Subjects were socially reared from birth to 56 days of age under enriched or standard rearing conditions. The enriched environment consisted of an assembly of plastic boxes in which a various number of objects (running wheels, pieces of plastic, etc.) offered the possibility of multiple activities. The subjects were subsequently tested in three situations: a spontaneous activity recorder, an elevated plus-maze test (a model of state anxiety), and a free exploration test (a model of trait anxiety). No group differences could be found in spontaneous activity. Environmental enrichment, however, decreased the level of both types of anxiety-like behavior in the C strain. In contrast, the level of trait anxiety of the B6 mice was not modified. The results were discussed in relation to possible CNS modifications, especially in the limbic system.

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  • Environmental enrichment reduces stress.

    “Environmental enrichment | Reduces anxiety [196,197], stress [196,197], and abnormal repetitive behaviour [198–200]. Reduces susceptibility to epilepsy [201] and osteoarthritis [202] and modifies the pathology of neurological disorders [203]. Increases foraging behaviour in fish [204].”

    From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [196]

  • Environmental enrichment reduces anxiety.

    “Environmental enrichment | Reduces anxiety [196,197], stress [196,197], and abnormal repetitive behaviour [198–200]. Reduces susceptibility to epilepsy [201] and osteoarthritis [202] and modifies the pathology of neurological disorders [203]. Increases foraging behaviour in fish [204].”

    From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [196]

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Metadata

Authors
Chapillon, P., Manneché, C., Belzung, C., & Caston, J.
Affiliations
  • Université de Rouen Normandie (FR)
  • Université de Tours (FR)
Corresponding author
Chapillon, P.
ORCID
Belzung, C.
Venue
Behavior Genetics
Publisher
Springer Science and Business Media LLC
Published
1999-01
Volume
29
Issue
1
Pages
41-46
ISSN
  • 0001-8244 (ISSN-L)
  • 1573-3297
DOI
10.1023/a:1021437905913
OpenAlex
W1491397924
Cited by
202
References
1
Citations by year
2026: 1 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 16 · 2013: 8 · 2012: 16
FWCI
9.56
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Behavior Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
environmental enrichment, inbred mouse strains, BALB/c mice, C57BL/6 mice, anxiety-like behavior, trait anxiety, state anxiety, emotional reactivity, spontaneous activity, elevated plus maze, free exploration, limbic system, social rearing
MeSH terms
Analysis of Variance, Animals, Animals, Newborn, Anxiety, Environment, Exploratory Behavior, Female, Housing, Animal, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Play and Playthings, Temperament, Mice

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