Cited by 516Heat shock proteins researchCell death mechanisms and regulationClusterin in disease pathology

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On the role of Hsp27 in regulating apoptosis

Concannon, C. G., Gorman, A. M., Samali, A.·2003·Apoptosis

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Abstract

Heat shock proteins (Hsps) comprise several different families of proteins that are induced in response to a wide variety of physiological and environmental insults. One such protein which is highly induced during the stress response is a 27-kDa protein, termed Hsp27 whose expression is seen to correlate with increased survival in response to cytotoxic stimuli. It has been shown to prevent cell death by a wide variety of agents that cause apoptosis. Hsp27 is a molecular chaperone with an ability to interact with a large number of proteins. Recent evidence has shown that Hsp27 regulates apoptosis through an ability to interact with key components of the apoptotic signalling pathway, in particular, those involved in caspase activation and apoptosis. This article will review recent advances in the field and will address some of the potential mechanisms by which Hsp27 functions as an anti-apoptotic molecule.

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Authors: Concannon, C. G., Gorman, A. M., & Samali, A.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
ORCID: Gorman, A. M.
Venue: Apoptosis
Publisher: Springer Science and Business Media LLC
Published: 2003-01
Volume: 8
Issue: 1
Pages: 61-70
ISSN: 1360-8185 (ISSN-L)
1573-675X
DOI: 10.1023/a:1021601103096
OpenAlex: W2144228610
Cited by: 513
References: 109
Citations by year: 2026: 8 · 2025: 11 · 2024: 5 · 2023: 21 · 2022: 11 · 2021: 18 · 2020: 24 · 2019: 19 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 28 · 2013: 26 · 2012: 31
FWCI: 11.83
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: APOPTOSIS (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Higher Education Authority
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Clusterin in disease pathology
Keywords: HSP27, heat shock proteins, anti-apoptotic proteins, caspase activation, molecular chaperones, cell survival
MeSH terms: Animals, Cytoskeleton, Enzyme Activation, Heat-Shock Proteins, Humans, Models, Biological, Neoplasm Proteins, Neoplasms, Oxidation-Reduction, Protein Binding, Signal Transduction, Apoptosis, Reactive Oxygen Species, Molecular Chaperones, Caspases, HSP27 Heat-Shock Proteins, Caspase Inhibitors

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On the role of Hsp27 in regulating apoptosis

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