Use of the Peroxisome Proliferator-Activated Receptor (PPAR) γ Ligand Troglitazone as Treatment for Refractory Breast Cancer: A Phase II Study
Abstract
Purpose To evaluate the therapeutic effects of the peroxisome proliferator-activated receptor (PPAR) gamma activating ligand, troglitazone, in patients with refractory metastatic breast cancer.Experimental design Patients with advanced breast cancer refractory to at least one chemotherapy regimen (ER negative tumors) or two hormonal regimens (ER positive tumors) were treated with troglitazone at 800 mg p.o. QD until disease progression, to determine the percentage of patients free of progression at 6 months. Tumor response, toxicity, and changes in serum tumor markers (CEA, CA27.29) that might reflect alteration in tumor differentiation, were also examined.Results Twenty-two patients were enrolled before suspension of protocol accrual and treatment when troglitazone was withdrawn from commercial availability following FDA warnings on hepatic toxicity. No objective responses (CR or PR) were observed; only three patients had SD at 8 weeks. Patients came off study for PD (16), DLT (1), FDA withdrawal (2), or other (3) reasons. No patients took troglitazone for more than 20 weeks; all had experienced disease progression or began other systemic therapy within 6 months. All patients with elevated serum tumor markers (CEA and CA27.29) at baseline had rising tumor markers within 8 weeks.Conclusions While clinical trials among different patient populations might uncover subtle effects on tumor differentiation, PPARgamma activation by troglitazone has little apparent clinical value among patients with treatment-refractory metastatic breast cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Only a few clinical trials of TZDs for cancer treatment have been conducted, and results have largely been negative.
“Only a few clinical trials of TZDs for cancer treatment have been conducted, and results have largely been negative (108).”
From Diabetes and Cancer (2010) · cites this paper as [108]
Cites
The mechanisms of action of PPARs
Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956 · see citing works
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Spiegelman, B. M. (1998) · Diabetes · doi:10.2337/diabetes.47.4.507 · Cited by 1,730 · see citing works
Self-citationAdipogenesis and Obesity: Rounding Out the Big Picture
Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,254 · see citing works
Self-citationTerminal Differentiation of Human Breast Cancer through PPARγ
Mueller, E., Sarraf, P., Tontonoz, P., Evans, R. M., Martin, K. J., Zhang, M., Fletcher, C., Singer, S., & Spiegelman, B. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80047-7 · Cited by 850 · see citing works
Self-citationElstner, E., Müller‐Tidow, C., Koshizuka, K., Williamson, E. A., Park, D. J., Asou, H., Shintaku, P. I., SAID, J. W., Heber, D., & Koeffler, H. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8806 · Cited by 805 · see citing works
Willson, T. M., Cobb, J. E., Cowan, D. J., Wiethe, R. W., Correa, I. D., Prakash, S. R., Beck, K. D., Moore, L. B., Kliewer, S. A., & Lehmann, J. M. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950395a · Cited by 638 · see citing works
Kubota, T., Koshizuka, K., Williamson, E. A., Asou, H., SAID, J. W., Holden, S. A., Miyoshi, I., & Koeffler, H. P. (1998) · PubMed · Cited by 589 · see citing works
Demetri, G. D., Fletcher, C. D. �., Mueller, E., Sarraf, P., Naujoks, R., Campbell, N., Spiegelman, B. M., & Singer, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3951 · Cited by 495 · see citing works
Self-citationMueller, E., Smith, M. R., Sarraf, P., Kroll, T. G., Aiyer, A., Kaufman, D. S., Oh, W. K., Demetri, G. D., Figg, W. D., Zhou, X.-P., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180329197 · Cited by 427 · see citing works
Self-citationNonhypoglycemic Effects of Thiazolidinediones
Parulkar, A., Pendergrass, M., Granda-Ayala, R., Lee, T. R., & Fonseca, V. A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-1-200101020-00014 · Cited by 410 · see citing works
Lessons from the glitazones: a story of drug development
Gale, E. A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04960-6 · Cited by 289 · see citing works
APC-dependent suppression of colon carcinogenesis by PPARγ
Girnun, G. D., Smith, W. M., Drori, S., Sarraf, P., Mueller, E., Eng, C., Nambiar, P. R., Rosenberg, D. W., Bronson, R. T., Edelmann, W., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162480299 · Cited by 277 · see citing works
Self-citationSuh, N., Wang, Y., Williams, C. R., Risingsong, R., Gilmer, T. M., Willson, T. M., & Sporn, M. B. (1999) · PubMed · Cited by 230 · see citing works
Rubin, G., Zhao, Y., Kalus, A. M., & Simpson, E. R. (2000) · PubMed · Cited by 190 · see citing works
Mehta, R. G. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.5.418 · Cited by 147 · see citing works
Troglitazone Inhibits Growth of MCF-7 Breast Carcinoma Cells by Targeting G1 Cell Cycle Regulators
Yin, F., Wakino, S., Liu, Z., Kim, S., Hsueh, W. A., Collins, A. R., Herle, A. J. V., & Law, R. E. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5491 · Cited by 143 · see citing works
Multicenter Phase II Study of Oral Bexarotene for Patients With Metastatic Breast Cancer
Esteva, F. J., Glaspy, J. A., Baidas, S. M., Laufman, L. R., Hutchins, L. F., Dickler, M. N., Tripathy, D., Cohen, R., DeMichele, A. M., Yocum, R. C., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.068 · Cited by 115 · see citing works
Self-citationSpencer, C. M., & Markham, A. (1997) · Drugs · doi:10.2165/00003495-199754010-00010 · Cited by 93 · see citing works
Pignatelli, M., Cortés‐Canteli, M., Lai, C., Santos, Á., & Pérez‐Castillo, A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.22.4117 · Cited by 58 · see citing works
PPARγ and colorectal carcinoma: Conflicts in a nuclear family
Seed, B. (1998) · Nature Medicine · doi:10.1038/1990 · Cited by 45 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366 · see citing works
Fat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works
Self-citationDiabetes and Cancer: A Consensus Report
Giovannucci, E. L., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20078 · Cited by 1,065 · see citing works
Obesity and diabetes: the increased risk of cancer and cancer-related mortality
Gallagher, E. J., & LeRoith, D. (2015) · Physiological Reviews · doi:10.1152/physrev.00030.2014 · Cited by 806 · see citing works
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
Peters, J. M., Shah, Y. M., & Gonzalez, F. J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3214 · Cited by 494 · see citing works
Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonists
Grommes, C., Landreth, G. E., & Heneka, M. T. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01509-8 · Cited by 440 · see citing works
Diabetes mellitus and breast cancer
Wolf, I., Sadetzki, S., Catane, R., Karasik, A., & Kaufman, B. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)01736-5 · Cited by 422 · see citing works
Vallée, A., & Lecarpentier, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00745 · Cited by 352 · see citing works
Differentiation therapy of leukemia: 3 decades of development.
Nowak, D., Stewart, D., & Koeffler, H. P. (2009) · Blood · doi:10.1182/blood-2009-01-198911 · Cited by 348 · see citing works
Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression
Park, J., Euhus, D., & Scherer, P. E. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0030 · Cited by 349 · see citing works
15d-PGJ2: The anti-inflammatory prostaglandin?
Scher, J. U., & Pillinger, M. H. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.09.008 · Cited by 348 · see citing works
Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence
Cheng, H. S., Tan, W., Low, Z. S., Marvalim, C., Lee, J. Y. H., & Tan, N. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205055 · Cited by 272 · see citing works
PPAR-α Modulators as Current and Potential Cancer Treatments
Chi, T., Wang, M., Wang, X., Ke, Y., Xie, F., Zehuan, L., & Wei, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.599995 · Cited by 244 · see citing works
Type 2 Diabetes Mellitus and Cancer: The Role of Pharmacotherapy
Shlomai, G., Neel, B. A., LeRoith, D., & Gallagher, E. J. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.67.4044 · Cited by 237 · see citing works
Peroxisome proliferator–activated receptor-δ attenuates colon carcinogenesis
Harman, F. S., Nicol, C. J. B., Marin, H. E., Ward, J. M., Gonzalez, F. J., & Peters, J. M. (2004) · Nature Medicine · doi:10.1038/nm1026 · Cited by 214 · see citing works
Seargent, J. M., Yates, E., & Gill, J. H. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705973 · Cited by 193 · see citing works
Schäffler, A., Schölmerich, J., & Buechler, C. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0456 · Cited by 185 · see citing works
Diabetes and Cancer: Cancer Should Be Screened in Routine Diabetes Assessment
Suh, S., & Kim, K. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0177 · Cited by 185 · see citing works
PPARγ signaling exacerbates mammary gland tumor developmentPreprint
Sáez, E., Rosenfeld, J. M., Livolsi, A., Olson, P., Lombardo, E., Nelson, M. C., Banayo, E., Cardiff, R. D., Izpisúa‐Belmonte, J. C., & Evans, R. M. (2004) · Genes & Development · doi:10.1101/gad.1167804 · Cited by 178 · see citing works
Peroxisome proliferator-activated receptors and cancer: challenges and opportunities
Youssef, J., & Badr, M. Z. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01383.x · Cited by 156 · see citing works
PPARβ/δ selectively induces differentiation and inhibits cell proliferation
Kim, D. J., Bility, M. T., Billin, A. N., Willson, T. M., Gonzalez, F. J., & Peters, J. M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401713 · Cited by 146 · see citing works
Thiazolidinediones as anti-cancer agents.
Blanquicett, C., Roman, J., & Hart, C. M. (2008) · PubMed · Cited by 141 · see citing works
Minireview: Nuclear Receptors and Breast Cancer
Conzen, S. D. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0421 · Cited by 141 · see citing works
Reka, A. K., Kurapati, H., Narala, V. R., Bommer, G. T., Chen, J., Standiford, T. J., & Keshamouni, V. G. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0570 · Cited by 136 · see citing works
Zhang, X., Zhao, W., Hu, L., Zhao, L., & Huang, J. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.004 · Cited by 135 · see citing works
Peroxisome proliferator-activated receptor γ: a novel target for cancer therapeutics?
Han, S., & Roman, J. (2007) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328011e67d · Cited by 135 · see citing works
Peroxisome proliferator-activated receptor γ in malignant diseases
WANG, T., Xu, J., Yu, X., Yang, R., & Han, Z. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.08.011 · Cited by 127 · see citing works
Adipose Tissue, Obesity and Adiponectin: Role in Endocrine Cancer Risk
Tumminia, A., Vinciguerra, F., Parisi, M., Graziano, M., Sciacca, L., Baratta, R., & Frittitta, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122863 · Cited by 128 · see citing works
Synergy between PPARγ Ligands and Platinum-Based Drugs in Cancer
Girnun, G. D., Naseri, E., Vafai, S. B., Qu, L., Szwaya, J. D., Bronson, R. T., Alberta, J. A., & Spiegelman, B. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.025 · Cited by 128 · see citing works
Self-citationOndrey, F. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0326 · Cited by 126 · see citing works
Bren‐Mattison, Y., Putten, V. V., Chan, D. C. F., Winn, R. A., Geraci, M. W., & Nemenoff, R. A. (2004) · Oncogene · doi:10.1038/sj.onc.1208333 · Cited by 117 · see citing works
PPAR‐γAgonists and Their Effects on IGF‐I Receptor Signaling: Implications for Cancer
Belfiore, A., Genua, M., & Malaguarnera, R. (2009) · PPAR Research · doi:10.1155/2009/830501 · Cited by 116 · see citing works
Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future
Davidson, M., Mattison, D. R., Azoulay, L., & Krewski, D. R. (2017) · Critical Reviews in Toxicology · doi:10.1080/10408444.2017.1351420 · Cited by 114 · see citing works
Park, J., Morley, T. S., & Scherer, P. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202006 · Cited by 111 · see citing works
Muscat, G. E. O., Eriksson, N. A., Byth, K., Loi, S., Graham, J. D., Jindal, S., Davis, M. J., Clyne, C. D., Funder, J. W., Simpson, E. R., et al. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1265 · Cited by 111 · see citing works
Chemotherapy and Chemoprevention by Thiazolidinediones
Fröhlich, E., & Wahl, R. (2015) · BioMed Research International · doi:10.1155/2015/845340 · Cited by 105 · see citing works
Aiello, A., Pandini, G., Frasca, F., Conte, E., Murabito, A., Sacco, A., Genua, M., Vigneri, R., & Belfiore, A. (2006) · Endocrinology · doi:10.1210/en.2005-1610 · Cited by 105 · see citing works
Hic-5 regulates an epithelial program mediated by PPARγPreprint
Drori, S., Girnun, G. D., Tou, L., Szwaya, J. D., Mueller, E., Kia, X., Shivdasani, R. A., & Spiegelman, B. M. (2005) · Genes & Development · doi:10.1101/gad.1240705 · Cited by 102 · see citing works
Self-citationCrowe, D. L., & Chandraratna, R. A. S. (2004) · Breast Cancer Research · doi:10.1186/bcr913 · Cited by 101 · see citing works
Yee, L. D., Williams, N., Wen, P., Young, D. C., Lester, J., Johnson, M. V., Farrar, W. B., Walker, M. J., Povoski, S. P., Suster, S. M., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1947 · Cited by 98 · see citing works
The Insulin Receptor: A New Target for Cancer Therapy
Malaguarnera, R., & Belfiore, A. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00093 · Cited by 98 · see citing works
PPAR gamma, bioactive lipids, and cancer progression
Gregory, T. (2011) · Frontiers in bioscience · doi:10.2741/4021 · Cited by 95 · see citing works
The prince and the pauper. A tale of anticancer targeted agents
Dueñas‐González, A., García‐López, P., Herrera, L. A., Medina‐Franco, J. L., González‐Fierro, A., & Candelaria, M. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-82 · Cited by 91 · see citing works
Type 2 Diabetes and Cancer: What Is the Connection?
Cannata, D., Fierz, Y., Vijayakumar, A., & LeRoith, D. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20167 · Cited by 91 · see citing works
Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers
Lavudi, K., Nuguri, S. M., Olverson, Z. A., Dhanabalan, A. K., Patnaik, S., & Kokkanti, R. R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1254612 · Cited by 89 · see citing works
Peroxisome proliferator-activated receptor-γ ligands for the treatment of breast cancer
Fenner, M. H., & Elstner, E. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.6.557 · Cited by 88 · see citing works
Therapeutic potential of thiazolidinediones as anticancer agents
Panigrahy, D., Shen, L. Q., Kieran, M. W., & Kaipainen, A. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.12.1925 · Cited by 88 · see citing works
Regression of Drug-Resistant Lung Cancer by the Combination of Rosiglitazone and Carboplatin
Girnun, G. D., Chen, L., Silvaggi, J. M., Drapkin, R., Chirieac, L. R., Padera, R. F., Upadhyay, R., Vafai, S. B., Weissleder, R., Mahmood, U., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1128 · Cited by 84 · see citing works
Self-citationSamoszuk, M. K., Tan, J., & Chorn, G. (2005) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-5-5 · Cited by 83 · see citing works
Cell cycle proteins in epithelial cell differentiation: Implications for breast cancer
Caldon, C. E., Sutherland, R. L., & Musgrove, E. A. (2010) · Cell Cycle · doi:10.4161/cc.9.10.11474 · Cited by 78 · see citing works
Fröhlich, E., Machicao, F., & Whal, R. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.00973 · Cited by 77 · see citing works
Lecarpentier, Y., CLAES, V. A., Vallée, A., & Hébert, J. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0144-7 · Cited by 75 · see citing works
Carter, J. C., & Church, F. (2009) · PPAR Research · doi:10.1155/2009/345320 · Cited by 75 · see citing works
Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone
Yao, C., Lai, G., Chan, C., Cheng, A., Yang, Y., & Chuang, S. (2005) · International Journal of Cancer · doi:10.1002/ijc.21361 · Cited by 70 · see citing works
Salamone, S., Colin, C., Grillier‐Vuissoz, I., Kuntz, S., Mazerbourg, S., Flament, S., Martin, H., Richert, L., Chapleur, Y., & Boisbrun, M. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.02.044 · Cited by 67 · see citing works
The Role of PPARγ Ligands in Breast Cancer: From Basic Research to Clinical Studies
Augimeri, G., Giordano, C., Gelsomino, L., Plastina, P., Barone, I., Catalano, S., Andò, S., & Bonofiglio, D. (2020) · Cancers · doi:10.3390/cancers12092623 · Cited by 66 · see citing works
In Vitro and In Vivo Anti-Melanoma Effects of Ciglitazone
Botton, T., Puissant, A., Bahadoran, P., Annicotte, J., Lluis Fajas, A., Ortonne, J. ‐., Gozzerino, G., Zamoum, T., Tartare‐Deckert, S., Bertolotto, C., et al. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.346 · Cited by 65 · see citing works
Cyclooxygenase-2 Expression in Human Colorectal Cancer Is Unrelated to Overall Patient Survival
Fux, R., Schwab, M. G., Thon, K., Gleiter, C. H., & Fritz, P. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2586 · Cited by 65 · see citing works
Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer
Berstein, L. M. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.11.011 · Cited by 63 · see citing works
Suzuki, T., Hayashi, S., Miki, Y., Nakamura, Y., Moriya, T., Sugawara, A., Ishida, T., Ohuchi, N., & Sasano, H. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01075 · Cited by 62 · see citing works
Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone
Cheng, W. Y., Huynh, H., Chen, P., Peña‐Llopis, S., & Wan, Y. (2016) · eLife · doi:10.7554/elife.18501 · Cited by 60 · see citing works
Kristiansen, G., Jacob, J., Buckendahl, A., Grützmann, R., Alldinger, I., Sipos, B., Klöppel, G., Bahra, M., Langrehr, J. M., Neuhaus, P., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0834 · Cited by 58 · see citing works
Khandekar, M. J., Banks, A. S., Laznik-Bogoslavski, D., White, J. P., Choi, J. H., Kazak, L., Lo, J. C., Cohen, P., Wong, K., Kamenecka, T. M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717776115 · Cited by 55 · see citing works
Self-citationAl-Alem, L., Southard, R. C., Kilgore, M. W., & Curry, T. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016179 · Cited by 53 · see citing works
Bocca, C., Bozzo, F., Francica, S., Colombatto, S., & Miglietta, A. (2007) · International Journal of Cancer · doi:10.1002/ijc.22646 · Cited by 53 · see citing works
Egerod, F. L., Nielsen, H. S., Iversen, L., Thorup, I., Storgaard, T., & Oleksiewicz, M. B. (2005) · Biomarkers · doi:10.1080/13547500500218682 · Cited by 53 · see citing works
Jarrar, M. H., & Baranova, A. V. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00003.x · Cited by 52 · see citing works
The Role of PPARs in Breast Cancer
Zhao, B., Xin, Z., Ren, P., & Wu, H. (2022) · Cells · doi:10.3390/cells12010130 · Cited by 50 · see citing works
Tian, L., Zhou, J., Casimiro, M. C., Liang, B., Ojeifo, J. O., Wang, M., Hyslop, T., Wang, C., & Pestell, R. G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2067 · Cited by 50 · see citing works
Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis
Bandera-Merchán, B., Tinahones, F. J., & Macías‐González, M. (2016) · PPAR Research · doi:10.1155/2016/2308249 · Cited by 50 · see citing works
Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue
Heudobler, D., Rechenmacher, M., Lüke, F., Vogelhuber, M., Pukrop, T., Herr, W., Ghibelli, L., Gerner, C., & Reichle, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113540 · Cited by 50 · see citing works
The potential of antidiabetic thiazolidinediones for anticancer therapy
Galli, A., Mello, T., Ceni, E., Surrenti, E., & Surrenti, C. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.9.1039 · Cited by 50 · see citing works
Yoo, J. Y., Yang, S.-H., Lee, J. E., Cho, D. G., Kim, H. K., Kim, S. H., Kim, I. S., Hong, J. T., Sung, J. H., Son, B. C., et al. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-0890-8 · Cited by 49 · see citing works
Peroxisome Proliferator‐Activated Receptors: New Players in the Field of Reproduction
Tóth, B., Hornung, D., Scholz, C., Djalali, S., Friese, K., & Jeschke, U. (2007) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2007.00514.x · Cited by 48 · see citing works
Mora, F. D., Jones, D. K., Desai, P. V., Patny, A., Avery, M. A., Feller, D. R., Smillie, T. J., Zhou, Y., & Nagle, D. G. (2006) · Journal of Natural Products · doi:10.1021/np050397q · Cited by 48 · see citing works
An, J.-U., Song, Y., Kim, K.-R., Ko, Y., Yoon, D., & Oh, D. (2018) · Nature Communications · doi:10.1038/s41467-017-02543-8 · Cited by 45 · see citing works
PPARγ Physiology and Pathology in Gastrointestinal Epithelial Cells
Thompson, E. A. (2007) · Molecules and Cells · doi:10.1016/s1016-8478(23)07325-9 · Cited by 45 · see citing works
Xuan, D. T. M., Wu, C.-C., Kao, T., Ta, H. D. K., Anuraga, G., Andriani, V., Athoillah, M., Chiao, C.-C., Wu, Y.-F., Lee, K., et al. (2021) · Aging · doi:10.18632/aging.203722 · Cited by 43 · see citing works
Chen, L., Yuan, Y., Kar, S., Kanchi, M. M., Arora, S., Kim, J. E., Koh, P. F., Yousef, E. M., Samy, R. P., Shanmugam, M. K., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0739 · Cited by 42 · see citing works
Yousefi, B., Samadi, N., Baradaran, B., Shafiei‐Irannejad, V., & Zarghami, N. (2016) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12737 · Cited by 41 · see citing works
Li, S., Zhou, Q., He, H., Zhao, Y., & Liu, Z. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.317487 · Cited by 40 · see citing works
Peroxisome Proliferator‐activated Receptors and their Relevance to Dermatology
Friedmann, P. S., Cooper, H. L., & Healy, E. (2005) · Acta Dermato Venereologica · doi:10.1080/00015550510030104 · Cited by 40 · see citing works
Synergistic Effects of PPAR γ Ligands and Retinoids in Cancer Treatment
Shimizu, M., & Moriwaki, H. (2008) · PPAR Research · doi:10.1155/2008/181047 · Cited by 40 · see citing works
Ota, K., Ito, K., Suzuki, T., Saito, S., Tamura, M., Hayashi, S., Okamura, K., Sasano, H., & Yaegashi, N. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1833 · Cited by 40 · see citing works
A Role for the PPARγ in Cancer Therapy
Campbell, M. J., Carlberg, C., & Koeffler, H. P. (2008) · PPAR Research · doi:10.1155/2008/314974 · Cited by 39 · see citing works
Lecomte, J., Flament, S., Salamone, S., Boisbrun, M., Mazerbourg, S., Chapleur, Y., & Grillier‐Vuissoz, I. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9886-z · Cited by 39 · see citing works
Peroxisome proliferator‐activated receptors as therapeutic target for cancer
Wang, Y., Lei, F., Lin, Y., Han, Y., Yang, L., & Tan, H. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17931 · Cited by 38 · see citing works
Arousal of cancer-associated stromal fibroblasts
Brentnall, T. A. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.21453 · Cited by 37 · see citing works
The Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells
Antonosante, A., d’Angelo, M., Castelli, V., Catanesi, M., Iannotta, D., Giordano, A., Ippoliti, R., Benedetti, E., & Cimini, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071907 · Cited by 37 · see citing works
PPARGEpigenetic Deregulation and Its Role in Colorectal Tumorigenesis
Sabatino, L., Fucci, A., Pancione, M., & Colantuoni, V. (2012) · PPAR Research · doi:10.1155/2012/687492 · Cited by 37 · see citing works
Clinical Use of PPARγ Ligands in Cancer
Hatton, J. L., & Yee, L. D. (2008) · PPAR Research · doi:10.1155/2008/159415 · Cited by 36 · see citing works
Involvement of PPARα in the growth inhibitory effect of arachidonic acid on breast cancer cells
Bocca, C., Bozzo, F., Martinasso, G., Canuto, R. A., & Miglietta, A. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508942161 · Cited by 36 · see citing works
Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer
Garattini, E., Bolis, M., Gianni’, M., Paroni, G., Fratelli, M., & Terao, M. (2016) · Oncotarget · doi:10.18632/oncotarget.7410 · Cited by 36 · see citing works
New Insights into Anticarcinogenic Properties of Adiponectin
Delort, L., Jardé, T., Dubois, V., Vasson, M., & Caldefie‐Chezet, F. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-398313-8.00015-4 · Cited by 35 · see citing works
Yang, W., Li, Y., Song, X., Xu, J., & Xie, J. (2017) · Oncotarget · doi:10.18632/oncotarget.15721 · Cited by 35 · see citing works
Moreno-Vega, A. I., Vega-Riveroll, L. J., Ayala, T., Peralta, G., Torres-Martel, J. M., Rojas, J., Mondragón, P., Domínguez, A., Obaldía, R. D., Avecilla-Guerrero, C., et al. (2019) · Nutrients · doi:10.3390/nu11071623 · Cited by 35 · see citing works
Wang, D., Ning, W., Xie, D., Guo, L., & DuBois, R. N. (2011) · Oncogene · doi:10.1038/onc.2011.299 · Cited by 33 · see citing works
PPAR trilogy from metabolism to cancer
Nahle, Z. A. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000134360.30911.bb · Cited by 34 · see citing works
Deciphering the Roles of Thiazolidinediones and PPAR γ in Bladder Cancer
Chiu, M., McBeth, L., Sindhwani, P., & Hinds, T. D. (2017) · PPAR Research · doi:10.1155/2017/4810672 · Cited by 34 · see citing works
Peroxisome proliferator-activated receptors: Key regulators of tumor progression and growth
Asgharzadeh, F., Memarzia, A., Alikhani, V., Beigoli, S., & Boskabady, M. H. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102039 · Cited by 33 · see citing works
- Authors
- Burstein, H. J., Demetri, G. D., Mueller, E., Sarraf, P., Spiegelman, B. M., & Winer, E. P.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Brigham and Women's Hospital (US)
- Venue
- Breast Cancer Research and Treatment
- Published
- 2003-06
- Volume
- 79
- Issue
- 3
- Pages
- 391-397
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W1968980738
- Cited by
- 228
- References
- 21
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 14 · 2020: 5 · 2019: 7 · 2018: 13 · 2017: 11 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 10 · 2012: 18
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- troglitazone, PPARγ agonists, metastatic breast cancer, estrogen receptor-negative breast cancer, estrogen receptor-positive breast cancer, tumor markers, CEA, CA 27.29, tumor differentiation, drug toxicity, disease progression
- MeSH terms
- Troglitazone, Administration, Oral, Adult, Aged, Antineoplastic Agents, Breast Neoplasms, Chromans, Female, Humans, Liver, Middle Aged, Neoplasm Invasiveness, Thiazoles, Treatment Outcome, Disease Progression, Thiazolidinediones
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review