Cited by 96Mass Spectrometry Techniques and ApplicationsChemical Synthesis and AnalysisAdvanced Proteomics Techniques and Applications

The DOI matches its Crossref record; 14 of the 15 references it cites were found in a registry or an index.

Affinity Selection and Mass Spectrometry-Based Strategies to Identify Lead Compounds in Combinatorial Libraries

Kaur, Surinder, McGuire, Lisa, Tang, Dazhi, Dollinger, Gavin, Huebner, Verena·1997·Journal of Protein Chemistry

DOI 10.1023/a:1026369729393

Open this paper in CoChat — free account

Abstract

The screening of diverse libraries of small molecules created by combinatorial synthetic methods is a recent development which has the potential to accelerate the identification of lead compounds in drug discovery. We have developed a direct and rapid method to identify lead compounds in libraries involving affinity selection and mass spectrometry. In our strategy, the receptor or target molecule of interest is used to isolate the active components from the library physically, followed by direct structural identification of the active compounds bound to the target molecule by mass spectrometry. In a drug design strategy, structurally diverse libraries can be used for the initial identification of lead compounds. Once lead compounds have been identified, libraries containing compounds chemically similar to the lead compound can be generated and used to optimize the binding characteristics. These strategies have also been adopted for more detailed studies of protein-ligand interactions.

Integrity signals

Registry

Crossref · 10.1023/a:1026369729393

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Synthesis and Applications of Small Molecule Libraries
Thompson, L. A., & Ellman, J. A. (1996) · Chemical Reviews · doi:10.1021/cr9402081 · Cited by 1,456
Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
Zuckermann, R. N., Kerr, J. M., Kent, S. B. H., & Moos, W. H. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00052a076 · Cited by 1,279
General method for rapid synthesis of multicomponent peptide mixtures
Furka, Á., Sebestyén, F., ASGEDOM, M., & Dibó, G. (1991) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1991.tb00765.x · Cited by 1,160
Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions
Gordon, E. M., Barrett, R. W., Dower, W. J., Fodor, S. P. A., & Gallop, M. A. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00036a001 · Cited by 1,142
Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries
Gallop, M. A., Barrett, R. W., Dower, W. J., Fodor, S. P. A., & Gordon, E. M. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00035a001 · Cited by 1,135
New developments in biochemical mass spectrometry: electrospray ionization.
Smith, R. D., Loo, J., Edmonds, C. G., Barinaga, C., & Udseth, H. (1990) · Analytical Chemistry · doi:10.1021/ac00208a002 · Cited by 975
Peptoids: a modular approach to drug discovery.
Simon, R. J., Kania, R. S., Zuckermann, R. N., Huebner, V. D., Jewell, D. A., Banville, S. C., Ng, S., Wang, L., Rosenberg, S., & Marlowe, C. K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9367 · Cited by 956
Self-citation
Combinatorial synthesis — the design of compound libraries and their application to drug discovery
Terrett, N. K., Gardner, M., Gordon, D. W., Kobylecki, R. J., & Steele, J. (1995) · Tetrahedron · doi:10.1016/0040-4020(95)00467-m · Cited by 660
Measuring Diversity: Experimental Design of Combinatorial Libraries for Drug Discovery
Martin, É., Blaney, J. M., Siani, M. A., Spellmeyer, D. C., Wong, A. K., & Moos, W. H. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00009a003 · Cited by 298

Show all 15 references

Research works printed but not linked: 4

Furka, A., Sebestyen, F., Asgedom. M., and Dibo, G. (1988). In Abstracts 14th International Congress of Biochemistry, Prague, Czechoslovakia, Vol. 5, p. 47.
Huebner, V., Kaur, S., McGuire, L., Tang, D., and Dollinger, G. (1996). In Proceedings 44th Annual Conference on Mass Spectrometry and Allied Topics, Portland, OR, May 12–16, 1996, in press.
Kaur, S., Tang, D., Simon, R. J., Goff, D., and Zuckermann, R. N. (1994). In Proceedings 42nd Annual Conference on Mass Spectrometry and Allied Topics, Chicago, Il, May 29–June 3, 1994, p. 408.
Kaur, S., Huebner, V., Tang, D., McGuire, L., Drummond, R., Csetjey, J., Stratton-Thomas, J., Rosenberg, S., Figliozzi, G., Banville, S., Zuckermann, R., and Dollinger, G. (1995). In Proceedings 43rd Annual Conference on Mass Spectrometry and Allied Topics, Atlanta, GA, May 21–26, 1995, p. 30.

Sorted by citations

Tethering: Fragment-Based Drug Discovery
Erlanson, D. A., Wells, J. A., & Braisted, A. C. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.33.110502.140409 · Cited by 385
Mixture-Based Synthetic Combinatorial Libraries
Houghten, R. A., Pinilla, C., Appel, J. R., Blondelle, S. E., Dooley, C. T., Eichler, J., Nefzi, A., & Ostresh, J. M. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990174v · Cited by 260
Peptoid origins
Zuckermann, R. N. (2010) · Biopolymers · doi:10.1002/bip.21573 · Cited by 241
LC/MS applications in drug development
Lee, M. S., & Kerns, E. H. (1999) · Mass Spectrometry Reviews · doi:10.1002/(sici)1098-2787(1999)18:3/4 · Cited by 408
Receptor–ligand binding assays: Technologies and Applications
de Jong, L. A. A., Uges, D. R. A., Franke, J. P., & Bischoff, R. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.10.002 · Cited by 214
Ultra-large chemical libraries for the discovery of high-affinity peptide binders
Quartararo, A. J., Gates, Z. P., Somsen, B. A., Hartrampf, N., Ye, X., Shimada, A., Kajihara, Y., Ottmann, C., & Pentelute, B. L. (2020) · Nature Communications · doi:10.1038/s41467-020-16920-3 · Cited by 160
High-Throughput Solution-Based Medicinal Library Screening against Human Serum Albumin
Flarakos, J., Morand, K. L., & Vouros, P. (2005) · Analytical Chemistry · doi:10.1021/ac048685z · Cited by 137
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants
van Breemen, R. B., Muchiri, R. N., Bates, T. A., Weinstein, J. B., Leier, H. C., Farley, S., & Tafesse, F. G. (2022) · Journal of Natural Products · doi:10.1021/acs.jnatprod.1c00946 · Cited by 135
A General Technique To Rank Protein−Ligand Binding Affinities and Determine Allosteric versus Direct Binding Site Competition in Compound Mixtures
Annis, D. A., Nazef, N., Chuang, C., Scott, M. P., & Nash, H. M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048365x · Cited by 130
Combinatorial Chemistry and Mass Spectrometry in the 21st Century Drug Discovery Laboratory
Kassel, D. B. (2001) · Chemical Reviews · doi:10.1021/cr990085q · Cited by 114
SpeedScreen: label-free liquid chromatography–mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands
Muckenschnabel, I., Falchetto, R. A., Mayr, L. M., & Filipuzzi, I. (2003) · Analytical Biochemistry · doi:10.1016/j.ab.2003.09.040 · Cited by 105
Mass Spectrometry Innovations in Drug Discovery and Development
Papac, D. I., & Shahrokh, Z. (2001) · Pharmaceutical Research · doi:10.1023/a:1011049231231 · Cited by 104
An affinity selection–mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries
Annis, D. A., Athanasopoulos, J., Curran, P. J., Felsch, J. S., Kalghatgi, K., Lee, W. H., Nash, H. M., Orminati, J.-P. A., Rosner, K. E., Shipps, G. W., et al. (2004) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2003.11.022 · Cited by 100
Chemical ligands, genomics and drug discovery
Lenz, G. R., Nash, H. M., & Jindal, S. (2000) · Drug Discovery Today · doi:10.1016/s1359-6446(00)01468-9 · Cited by 85
Biochemical applications of mass spectrometry in pharmaceutical drug discovery
Geoghegan, K. F., & Kelly, M. A. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20019 · Cited by 78
MS/NMR: A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling Size Exclusion Chromatography, Mass Spectrometry, and Nuclear Magnetic Resonance Spectroscopy
Moy, F. J., Haraki, K., Mobilio, D., Walker, G., Powers, R., Tabei, K., Tong, H., & Siegel, M. M. (2001) · Analytical Chemistry · doi:10.1021/ac0006270 · Cited by 66
Impact of mass spectrometry on combinatorial chemistry
Süßmuth, R. D., & Jung, G. (1999) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00513-1 · Cited by 63
Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries
Cancilla, M. T., Leavell, M. D., Chow, J., & Leary, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220403997 · Cited by 61
Hollow fiber based affinity selection combined with high performance liquid chromatography–mass spectroscopy for rapid screening lipase inhibitors from lotus leaf
Tao, Y., Zhang, Y., Wáng, Y., & Cheng, Y. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.04.058 · Cited by 61
Rapid drug metabolite profiling using fast liquid chromatography, automated multiple-stage mass spectrometry and receptor-binding
Lim, H., Stellingweif, S., Sisenwine, S. F., & Chan, K.-K. (1999) · Journal of Chromatography A · doi:10.1016/s0021-9673(98)00956-x · Cited by 60
Biomedical and Biological Mass Spectrometry
Mano, N., & Goto, J. (2003) · Analytical Sciences · doi:10.2116/analsci.19.3 · Cited by 58
Kinetics and performance of a co-immobilised system of amyloglucosidase andZymomonas mobilis
Hellendoorn, L., Ottengraf, S. P. P., van den Heuvel, J. C., Pennings, J. A. M. M., dos Santos, V. A. P. M., & Wijffels, R. H. (1999) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19990620)63:6 · Cited by 6
Determining Affinity-Selected Ligands and Estimating Binding Affinities by Online Size Exclusion Chromatography/Liquid Chromatography−Mass Spectrometry
Blom, K. F., Larsen, B. S., & McEwen, C. N. (1998) · Journal of Combinatorial Chemistry · doi:10.1021/cc980010k · Cited by 57
Immobilized magnetic beads based multi-target affinity selection coupled with high performance liquid chromatography–mass spectrometry for screening anti-diabetic compounds from a Chinese medicine “Tang-Zhi-Qing”
Tao, Y., Chen, Z., Zhang, Y., Wáng, Y., & Cheng, Y. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.02.024 · Cited by 54
Analysis and screening of combinatorial libraries using mass spectrometry
Shin, Y. G., & van Breemen, R. B. (2001) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.278 · Cited by 50
Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries
Foley, T. L., Burchett, W., Chen, Q., Flanagan, M. E., Kapinos, B., Li, X.-Y., Montgomery, J. I., Ratnayake, A. S., Zhu, H., & Peakman, M. (2021) · SLAS DISCOVERY · doi:10.1177/2472555220979589 · Cited by 49
Discovery and Characterization of Orthosteric and Allosteric Muscarinic M2 Acetylcholine Receptor Ligands by Affinity Selection–Mass Spectrometry
Whitehurst, C. E., Nazef, N., Annis, D. A., Hou, Y., Murphy, D. M., Spacciapoli, P., Yao, Z., Ziebell, M. R., Cheng, C. C., Shipps, G. W., et al. (2006) · SLAS DISCOVERY · doi:10.1177/1087057105284340 · Cited by 49
Native metabolomics identifies the rivulariapeptolide family of protease inhibitors
Reher, R., Aron, A. T., Fajtová, P., Stincone, P., Wagner, B., Pérez-Lorente, A. I., Liu, C., Shalom, I. Y. B., Bittremieux, W., Wang, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32016-6 · Cited by 53
Mass spectrometry and combinatorial chemistry: a short outline
Triolo, A., Altamura, M., Cardinali, F., Sisto, A., & Maggi, C. A. (2001) · Journal of Mass Spectrometry · doi:10.1002/jms.238 · Cited by 46
Screening for High-Affinity Ligands to theSrcSH2 Domain Using Capillary Isoelectric Focusing-Electrospray Ionization Ion Trap Mass Spectrometry
Lyubarskaya, Y. V., Carr, S. A., Dunnington, D. J., Prichett, W. P., Fisher, S. M., Appelbaum, E. R., Jones, C. S., & Karger, B. L. (1998) · Analytical Chemistry · doi:10.1021/ac980330q · Cited by 45
Affinity selection mass spectrometry speeding drug discovery
Prudent, R., Lemoine, H., Walsh, J. J., & Roche, D. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103760 · Cited by 43
Triaging of DNA-Encoded Library Selection Results by High-Throughput Resynthesis of DNA–Conjugate and Affinity Selection Mass Spectrometry
Su, W., Ge, R., Ding, D., Chen, W., Wang, W., Yan, H., Wang, W., Yuan, Y., Liu, H., Zhang, M., et al. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00170 · Cited by 43
Strategic Use of Affinity-Based Mass Spectrometry Techniques in the Drug Discovery Process
Kelly, M. A., McLellan, T. J., & Rosner, P. J. (2001) · Analytical Chemistry · doi:10.1021/ac010569y · Cited by 42
Affinity selection–mass spectrometry for the discovery of pharmacologically active compounds from combinatorial libraries and natural products
Muchiri, R. N., & van Breemen, R. B. (2020) · Journal of Mass Spectrometry · doi:10.1002/jms.4647 · Cited by 44
Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries
Vinogradov, A. A., Gates, Z. P., Zhang, C., Quartararo, A. J., Halloran, K. H., & Pentelute, B. L. (2017) · ACS Combinatorial Science · doi:10.1021/acscombsci.7b00109 · Cited by 41
Competitive Binding Assays Made Easy with a Native Marker and Mass Spectrometric Quantification
Höfner, G. C., & Wanner, K. T. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200351806 · Cited by 40
Continuous-Flow, On-Line Monitoring of Biospecific Interactions Using Electrospray Mass Spectrometry
Hogenboom, A. C., de Boer, A. R., Derks, R. J. E., & Irth, H. (2001) · Analytical Chemistry · doi:10.1021/ac010026o · Cited by 37
Methods of screening combinatorial libraries using immobilized or restrained receptors
Woodbury, C. P., & Venton, D. L. (1999) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(99)00006-7 · Cited by 33
ALIS: An Affinity Selection–Mass Spectrometry System for the Discovery and Characterization of Protein–Ligand Interactions
Annis, A., Chuang, C., & Nazef, N. (2007) · Methods and principles in medicinal chemistry · doi:10.1002/9783527610907.ch3 · Cited by 32
Generating and analyzing combinatorial chemistry libraries
Wentworth, P., & Janda, K. D. (1998) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(98)80093-1 · Cited by 31
Automated affinity selection for rapid discovery of peptide binders
Zhang, G., Li, C., Quartararo, A. J., Loas, A., & Pentelute, B. L. (2021) · Chemical Science · doi:10.1039/d1sc02587b · Cited by 30
Automated High Throughput Multiple Target Screening of Molecular Libraries by Microfluidic MALDI-TOF MS
Hsieh, F., Keshishian, H., & Muir, C. (1998) · SLAS DISCOVERY · doi:10.1177/108705719800300305 · Cited by 28
Application of Affinity Selection/Mass Spectrometry to Determine the Structural Isomer of Parnafungins Responsible for Binding Polyadenosine Polymerase
Adam, G. C., Parish, C. A., Wisniewski, D., Meng, J., Liu, M., Calati, K., Stein, B. D., Athanasopoulos, J., Liberator, P., Roemer, T., et al. (2008) · Journal of the American Chemical Society · doi:10.1021/ja805531w · Cited by 27
Analytical tools for the detection and characterization of biologically active compounds from nature
van Elswijk, D. A., & Irth, H. (2002) · Phytochemistry Reviews · doi:10.1023/a:1026089809218 · Cited by 27
Drug discovery from natural products using affinity selection-mass spectrometry
Muchiri, R. N., & van Breemen, R. B. (2021) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2021.10.005 · Cited by 25
Unravelling seemingly complex chemistry of reactions using electrospray ionization mass spectrometry
Bakhtiar, R., & Hop, C. E. C. A. (1999) · Journal of Physical Organic Chemistry · doi:10.1002/(sici)1099-1395(199907)12:7 · Cited by 23
Assaying Small-Molecule−Receptor Interactions by Continuous Flow Competitive Displacement Chromatography/Mass Spectrometry
Sharma, J. P., Besanger, T. R., & Brennan, J. D. (2008) · Analytical Chemistry · doi:10.1021/ac702421e · Cited by 19
Kinetic capillary electrophoresis in screening oligonucleotide libraries for protein binders
Le, A. T. H., Krylova, S. M., & Krylov, S. N. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117061 · Cited by 18
Screening combinatorial libraries
Venton, D. L., & Woodbury, C. P. (1999) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/s0169-7439(99)00009-x · Cited by 18
Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2
Zhang, G., Brown, J. S., Quartararo, A. J., Li, C., Tan, X., Hanna, S., Antilla, S., Cowfer, A. E., Loas, A., & Pentelute, B. L. (2022) · Communications Chemistry · doi:10.1038/s42004-022-00625-3 · Cited by 16
Kompetitive Bindungsstudien leicht gemacht – mit nativem Marker und massenspektrometrischer Quantifizierung
Höfner, G. C., & Wanner, K. T. (2003) · Angewandte Chemie · doi:10.1002/ange.200351806 · Cited by 15
Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies
Dey, A. K., Banarjee, R., Boroumand, M., Rutherford, D. V., Strassheim, Q., Nyunt, T., Olinger, B., & Basisty, N. (2023) · Biology · doi:10.3390/biology12101301 · Cited by 12
Affinity-based ranking of ligands for DPP-4 from mixtures
Adam, G. C., Meng, J., Athanasopoulos, J., Zhang, X., & Chapman, K. T. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.02.040 · Cited by 13
Iterative size-exclusion chromatography coupled with liquid chromatographic mass spectrometry to enrich and identify tight-binding ligands from complex mixtures
Davis, R. G., Anderegg, R. J., & Blanchard, S. G. (1999) · Tetrahedron · doi:10.1016/s0040-4020(99)00685-7 · Cited by 13
Development of an analytical platform for the affinity screening of natural extracts by SEC-MS towards PPARα and PPARγ receptors
Soricellis, G. D., Rinaldi, F., Tengattini, S., Temporini, C., Negri, S., Capelli, D., Montanari, R., Cena, H., Salerno, S., Massolini, G., et al. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342666 · Cited by 12
Mass spectrometry–based bioassay for the screening of soluble orphan receptors
van Elswijk, D. A., Tjaden, U. R., van der Greef, J., & Irth, H. (2001) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(01)00445-6 · Cited by 11
Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers
Avital‐Shmilovici, M., Liu, X., Shaler, T. A., Lowenthal, A. C., Bourbon, P., Snider, J., Tambo-ong, A., Repellin, C. E., Yniguez, K., Sambucetti, L. C., et al. (2022) · ACS Central Science · doi:10.1021/acscentsci.1c01041 · Cited by 11
The Intersection of Strategy and Drug Research
Moos, W. H. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00033-x · Cited by 10
Metabolite-protein interactions: Native mass spectrometry and collision induced affinity selection mass spectrometry in natural product screening
Gu, Y., Liu, M., & Quinn, R. J. (2022) · Frontiers in Analytical Science · doi:10.3389/frans.2022.1014017 · Cited by 10
Applications of mass spectrometry to signal transduction
Resing, K. A., & Ahn, N. G. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00048-0 · Cited by 10
Driving Affinity Selection by Centrifugal Force
Harlan, J. E., Egan, D. A., Ladror, U. S., Snyder, S. W., Tang, M., BUKO, A. M., & Holzman, T. F. (2003) · Assay and Drug Development Technologies · doi:10.1089/154065803322302763 · Cited by 8
Identification of Ligands for Ion Channels: TRPM2
Gu, Y., Liu, M., Ma, L., & Quinn, R. J. (2024) · ChemBioChem · doi:10.1002/cbic.202300790 · Cited by 7
Breaking the boundaries of affinity selection-mass spectrometry: From ligand screening to target-ligand interaction insights
de Oliveira, P. C. O., do Amaral, B. S., Cardoso, C. L., Cass, Q. B., & de Moraes, M. C. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101379 · Cited by 7
Advancing Kir4.2 Channel Ligand Identification through Collision-Induced Affinity Selection Mass Spectrometry
Gu, Y., Liu, M., Ma, L., & Quinn, R. J. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.3c00781 · Cited by 6
Affinity selection mass spectrometry (AS-MS) for prospecting ligands in natural product libraries
do Amaral, B. S., de Moraes, M. C., Cardoso, C. L., & Cass, Q. B. (2025) · Frontiers in Natural Products · doi:10.3389/fntpr.2025.1562501 · Cited by 6
Aptamers
James, W. L. (2000) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a1402 · Cited by 6
Aptamers
Gopinath, S. C. B. (2011) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a1402.pub2 · Cited by 6
Medical applications of aptamers
Vallian, S., & Khazaei, M. (2009) · Research in Pharmaceutical Sciences · Cited by 5
Emerging challenges in ligand discovery: new opportunities for chromatographic assay
Ng, E. S. M., & Schriemer, D. C. (2005) · Expert Review of Proteomics · doi:10.1586/14789450.2.6.891 · Cited by 5
pyBinder: Quantitation to Advance Affinity Selection-Mass Spectrometry
Brown, J. S., Lee, M. A., Vuong, W., Loas, A., & Pentelute, B. L. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04445 · Cited by 5
Rapid Targeted Screening and Identification of Active Ingredients in Herbal Extracts through Ligand-Detected NMR and Database Matching
Huang, T., Chai, X., Li, S., Liu, B., Zhan, J., Wang, X., Xiao, X., Zhu, Q., Liu, C., Zeng, D., et al. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c02255 · Cited by 4
Studying Noncovalent Small Molecule Interactions with Protein and RNA Targets by Mass Spectrometry
Loo, J. A., Thanabal, V., & Mei, H. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-719-2_5 · Cited by 4
Mass Spectrometry and Drug Discovery
van Breemen, R. B., Newsome, A. G., & Dahl, J. H. (2010) · Wiley eBooks · doi:10.1002/0471266949.bmc012.pub2 · Cited by 4
Chapter 23. Genomics, Target Selection, Validation, and Assay Considerations in the Development of Antibacterial Screens
Guild, B. C. (1999) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)60585-0 · Cited by 3
Chapter 27. Existing and emerging strategies for the analytical characterization and profiling of compound libraries
Nemeth, G. A., & Kassel, D. B. (2001) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(01)36067-0 · Cited by 3
Aptamers
Gopinath, S. C. B. (2016) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a1402.pub3 · Cited by 3
Mass Spectrometry and Drug Discovery
van Breemen, R. B. (2003) · Wiley eBooks · doi:10.1002/0471266949.bmc012 · Cited by 4
Affinity selection mass spectrometry (AS-MS) as a tool to accelerate drug discovery efforts
Pandey, S., Samain, F., Nacham, O., Williams, J. D., & Elsen, N. L. (2026) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2026.2622373 · Cited by 3
Drug Design Methods to Regulate Protein–Protein Interactions
Poluri, K. M., Gulati, K., Tripathi, D. K., & Nagar, N. (2023) · Springer eBooks · doi:10.1007/978-981-99-2423-3_6 · Cited by 2
The Use of Mass Spectrometry
Vouros, P., & Fang, A. S. (2000) · CRC Press eBooks · doi:10.1201/9780203909966.ch2 · Cited by 1
Drug discovery
Miller, S. M., Moos, W. H., Munk, B. H., & Munk, S. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100625-2.00011-8 · Cited by 1
Affinity Interaction Profiling of Protein–Protein and Protein–Ligand Interactions Using Flow Analysis
Kool, J., Vermeulen, N. P. E., Lingeman, H., Derks, R. J. E., & Irth, H. (2008) · Wiley eBooks · doi:10.1002/9783527623259.ch17 · Cited by 1
References
Lee, M. S. (2002) · Wiley eBooks · doi:10.1002/0471218812.refs
Mass Spectrometry and Drug Discovery
van Breemen, R. B., Newsome, A. G., Dahl, J. H., & Muchiri, R. N. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc012.pub3 · Cited by 1
pyBinder: Label-free Quantitation to Advance Affinity Selection-Mass SpectrometryPreprint
Brown, J. S., Lee, M. A., Vuong, W., Loas, A., & Pentelute, B. L. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-lfqjb · Cited by 1
Combinatorial Chemistry Libraries, Analysis of
Kibbey, C. E. (2000) · Wiley eBooks · doi:10.1002/9780470027318.a1907
Nanotechnology: A novel approach towards cancer treatment
Goyal, R., & Kumar, S. (2014)
The U se of 19F NMR to Monitor Organic Reactions on Solid Supports
Preserve, L. (2004)
Using Fungal Genomes for the Discovery, Development, and Clinical Application of Novel and Current Antifungal Therapeutics
Black, T. A. (2003) · CRC Press eBooks · doi:10.1201/9780203911464.ch13
Bioanalytical Screening Methodologies for Accelerated Lead Generation and Optimization in Drug Discovery
Kyranos, J. N., & Chipman, S. D. (2000) · CRC Press eBooks · doi:10.1201/9780203909966.ch8
Mechanism of Action and Metabolism of Antineoplastic and Chemopreventive Agents
(2002) · CRC Press eBooks · doi:10.1201/9781420042696.ch5
Mass Spectrometry
English, R. D., & Haag, A. M. (2011) · Wiley eBooks · doi:10.1002/9780470571224.pse427
A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural PolymersPreprint
Avital‐Shmilovici, M., Liu, X., Shaler, T. A., Lowenthal, A. C., Bourbon, P., Snider, J., Tambo-ong, A., Repellin, C. E., Yniguez, K., Sambucetti, L. C., et al. (2021) · doi:10.33774/chemrxiv-2021-6wxh5-v3
AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor
Wang, M., Fu, S., Xu, Y., Gao, J., Ren, J., Yang, X., Xu, H., Sun, G., Li, Y., Wang, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.77386
BindingDB Entry 50036753: Mixture-based synthetic combinatorial libraries.
BindingDB (2012) · UC San Diego · doi:10.7270/q22z167w
BindingDB Entry 1965: Affinity-based ranking of ligands for DPP-4 from mixtures
BindingDB (2007) · UC San Diego · doi:10.7270/q2m906wf

Authors: Kaur, S., McGuire, L., Tang, D., Dollinger, G., & Huebner, V.
Affiliations: Biochimie des Protéines Membranaires (FR)
ORCID: Kaur, Surinder
Dollinger, Gavin
Venue: Journal of Protein Chemistry
Publisher: Springer Science and Business Media LLC
Published: 1997-07
Volume: 16
Issue: 5
Pages: 505-511
ISSN: 0277-8033 (ISSN-L)
1573-4943
DOI: 10.1023/a:1026369729393
OpenAlex: W1226074361
Cited by: 95
References: 15
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 2 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 2
FWCI: 5.21
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Protein Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords: affinity selection, combinatorial libraries, lead compound identification, small molecule library, protein-ligand interactions, receptor binding, drug discovery, library optimization
MeSH terms: Binding, Competitive, Chromatography, Affinity, Drug Evaluation, Preclinical, Ligands, Proteins, Receptors, Drug, Mass Spectrometry, Structure-Activity Relationship, Drug Design, Peptide Library

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Affinity Selection and Mass Spectrometry-Based Strategies to Identify Lead Compounds in Combinatorial Libraries

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks