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Membrane-Linked Systems Preventing Superoxide Formation
Abstract
New facts and ideas concerning the membrane-linked mechanisms preventing superoxide formation are summarised here. It is assumed that aerobic cells possess several lines of anti-ROS defence, including optimisation of the intracellular oxygen concentration, decrease in the concentration and life-time of one-electron O2 reductants such as CoQH; and mitochondrial and cell selections, i.e. elimination of mitochondria and cells producing ROS at high rate. It is postulated that ROS-dependent pore opening and ROS-dependent apoptosis are involved in mitochondrial and cell selections.
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“Δψm is an important factor for maintaining cellular energy homeostasis, and small reductions in Δψm induced by mild uncoupling were shown to decrease H2O2 emissions (51,52) and produce a natural antioxidant effect (53).”
From TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle (2019) · cites this paper as [53]
In the citing paper
“Protein oxidation can lead to unfolding and result in loss of catalytic function and degradation (289) [e.g., ROS can damage the Na/K ATPase complex (287)].”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [287]
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Purvis, A. C. (2004) · HortScience · doi:10.21273/hortsci.39.5.930 · Cited by 25
ZmPUMP encodes a maize mitochondrial uncoupling protein that is induced by oxidative stress
Brandalise, M. (2003) · Plant Science · doi:10.1016/s0168-9452(03)00159-6 · Cited by 24
Jabůrek, M., Průchová, P., Holendová, B., Galkin, A. S., & Ježek, P. (2021) · Antioxidants · doi:10.3390/antiox10050678 · Cited by 24
Metadata
- Authors
- Skulachev, V. P.
- Affiliations
- Lomonosov Moscow State University (RU)
- Corresponding author
- Skulachev, Vladimir P.
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 1997-06-01
- Volume
- 17
- Issue
- 3
- Pages
- 347-366
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- OpenAlex
- W1876476959
- Cited by
- 162
- References
- 59
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 8
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- superoxide, reactive oxygen species, intracellular oxygen concentration, coenzyme Q10, cell selection
- MeSH terms
- Aconitate Hydratase, Animals, Azotobacter, Bacteria, Cell Membrane, Cell Membrane Permeability, DNA, Mitochondrial, Humans, Mitochondria, Oxidation-Reduction, Permeability, Plants, Superoxides, Uncoupling Agents, Apoptosis, Reactive Oxygen Species
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