Superoxide in Apoptosis

Cai, Jiyang; Jones, Dean P.

doi:10.1074/jbc.273.19.11401

Cited by 765Cell death mechanisms and regulationMitochondrial Function and PathologyRedox biology and oxidative stress

Superoxide in Apoptosis

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Cai, Jiyang, Jones, Dean P.·1998·Journal of Biological Chemistry

DOI 10.1074/jbc.273.19.11401

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Abstract

Activation of apoptosis is associated with generation of reactive oxygen species. The present research shows that superoxide is produced by mitochondria isolated from apoptotic cells due to a switch from the normal 4-electron reduction of O2 to a 1-electron reduction when cytochrome c is released from mitochondria. Bcl-2, a protein that protects against apoptosis and blocks cytochrome c release, prevents superoxide production when it is overexpressed. The switch in electron transfer provides a mechanism for redox signaling that is concomitant with cytochrome c-dependent activation of caspases. The block of cytochrome c release provides a mechanism for the apparent antioxidant function of Bcl-2.

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Exogenous quinones can enhance ROS generation from isolated complex I.
“Exogenous quinones can enhance ROS generation from isolated complex I (65).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [65]

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Authors: Cai, J., & Jones, D. P.
Affiliations: Emory University (US)
Corresponding author: Jones, Dean P.
ORCID: Cai, Jiyang
Jones, Dean P.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-05
Volume: 273
Issue: 19
Pages: 11401-11404
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.19.11401
OpenAlex: W1980969730
Cited by: 765
References: 45
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 16 · 2020: 9 · 2019: 12 · 2018: 13 · 2017: 14 · 2016: 18 · 2015: 16 · 2014: 17 · 2013: 20 · 2012: 29
FWCI: 19.81
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8193 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: University of Minnesota
National Institutes of Health
National Eye Institute (EY07892)
National Institute of Environmental Health Sciences (ES09047, R01ES009047)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: superoxide, apoptosis, reactive oxygen species, cytochrome c release, mitochondria, Bcl-2, redox signaling, caspase activation, electron transfer, antioxidant function
MeSH terms: Cytochrome c Group, Glutathione, Humans, Mitochondria, Oxidation-Reduction, Superoxides, Time Factors, Apoptosis, HL-60 Cells, Proto-Oncogene Proteins c-bcl-2, Staurosporine

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Superoxide in Apoptosis

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