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Cited by 190Metalloenzymes and iron-sulfur proteinsMitochondrial Function and PathologyRedox biology and oxidative stress

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Superoxide-Driven Aconitase FE-S Center Cycling

Gardner, Paul R.·1997·Bioscience Reports
DOI 10.1023/a:1027383100936
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Abstract

O−2 produced by the autoxidation of respiratory chain electron carriers, and other cellular reductants, inactivates bacterial and mammalian iron-sulfur-containing (de)hydratases including the citric acid cycle enzyme aconitase. Release of the solvent-exposed iron atom and oxidation of the [4Fe-4S]2+ cluster accompanies loss of catalytic activity. Rapid reactivation is achieved by iron-sulfur cluster reduction and Fe2+ insertion. Inactivation-reactivation is a dynamic and cyclical process which modulates aconitase and (de)hydratase activities in Escherichia coli and mammalian cells. The balance of inactive and active aconitase provides a sensitive measure of the changes in steady-statO−2 levels occuring in living cells and mitochondria under stress conditions. Aconitases are also inactivated by other oxidants including O2, H2O2, NO., and ONOO− which are associated with inflammation, hyperoxia and other pathophysiological conditions. Loss of aconitase activity during oxidant stress may impair energy production, and the liberation of reactive iron may further enhance oxidative damage. Iron-sulfur center cycling may also serve adaptive functions by modulating gene expression or by signaling metabolic quiescence.

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Crossref · 10.1023/a:1027383100936

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Metadata

Authors
Gardner, P. R.
Affiliations
Cincinnati Children's Hospital Medical Center (US)
Corresponding author
Gardner, Paul R.
ORCID
Gardner, Paul R.
Venue
Bioscience Reports
Publisher
Portland Press Ltd.
Published
1997-02-01
Volume
17
Issue
1
Pages
33-42
ISSN
  • 0144-8463 (ISSN-L)
  • 1573-4935
DOI
10.1023/a:1027383100936
OpenAlex
W73773881
Cited by
190
References
53
Citations by year
2026: 5 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 9
FWCI
8.91
Type
journal article
Language
en
Open access
closed
Locations
  • Bioscience Reports (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • American Lung Association
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
aconitase, iron-sulfur clusters, [4Fe-4S] cluster, superoxide, autoxidation, enzyme inactivation, reactivation, oxidative stress, reactive oxygen species, mitochondrial iron metabolism, Escherichia coli, metabolic quiescence, oxidative damage
MeSH terms
Aconitate Hydratase, Animals, Humans, Iron-Sulfur Proteins, Superoxides

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