Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor
Abstract
Tumor necrosis factor (TNF) induces the synthesis of protein(s) that can protect cells against subsequent killing by TNF in the presence of cycloheximide. Here we demonstrate that manganous superoxide dismutase (MnSOD), a mitochondrial enzyme involved in the scavenging of superoxide radicals (O2-), is such a protein. Overexpression of MnSOD confers increased resistance to TNF plus cycloheximide on the 293 human embryonic kidney cell line. Conversely, expression of antisense MnSOD RNA renders these cells sensitive to TNF even in the absence of cycloheximide. The TNF sensitivity of the ME-180 human cervical carcinoma cell line can also be modulated through expression of sense and antisense MnSOD RNAs. These data identify MnSOD as an important determinant of cellular resistance to TNF and implicate mitochondrially generated O2- as a key component of TNF-mediated tumor cell killing.
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SOD2 is essential for cellular survival following TNFα treatment.
“SOD2 is thus essential for cellular survival following TNFα treatment 61–63”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [62]
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- Authors
- Wong, G. H. W., Elwell, J. H., Oberley, L. W., & Goeddel, D. V.
- Affiliations
- Genentech (US)
- University of Iowa (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1989-09
- Volume
- 58
- Issue
- 5
- Pages
- 923-931
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2069333165
- Cited by
- 802
- References
- 67
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 4 · 2015: 10 · 2014: 10 · 2013: 3 · 2012: 8
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01ca041267-04a3)
- Genentech
- National Cancer Institute (1R01-CA41267)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- TNF-α, TNF resistance, cytotoxicity, superoxide, mitochondrial enzymes, antisense RNA, cycloheximide, ME180 cells, 293 cells, cell death
- MeSH terms
- Cell Line, Humans, Manganese, Mitochondria, RNA, Superoxides, Superoxide Dismutase, Transfection, Tumor Necrosis Factor-alpha, RNA, Antisense, In Vitro Techniques
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