The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Hemochromatosis and the enigma of misplaced iron: Implications for infectious disease and survival
Abstract
The mystery surrounding the apparent lack of iron within the macrophages of individuals with hereditary hemochromatosis, a condition of excessive uptake of dietary iron, has yet to be fully explained. We have suggested that iron deficiency of macrophages in people with hereditary hemochromatosis mutations is associated with increased resistance to infection by Yersinia and other intracellular pathogens, a selection pressure resulting in unusually high current population frequencies of hereditary hemochromatosis mutations. Such selection pressure has been called Epidemic Pathogenic Selection (EPS). In support of the theory of EPS, a considerable number of virulent species of bacteria multiply mainly in iron-rich macrophages of their mammalian hosts. Among these fastidious pathogens are strains of Chlamydia, Coxiella, Francisella, Legionella, Mycobacterium, Salmonella and Yersinia. Iron deficiency of macrophages of persons with hereditary hemochromatosis gene mutations may result in increased resistance to members of these bacterial pathogens. People with genes that result in hereditary hemochromatosis may be protected against coronary artery disease associated with Chlamydia and Coxiella infection in the absence of iron overload. In the clinical setting, when a patient appears to be iron deficient, the reason for this should be carefully evaluated. Iron supplementation may adversely affect the health of individuals who have mounted an acute phase response to infection, injury or stress, or who carry genes predisposing them to iron overload disorders.
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“The selective pressure imposed by intracellular pathogens may have contributed to the evolutionary conservation of the HFE C282Y mutation, accounting for its high allelic frequency in Caucasians (Datz et al., 1998; Moalem et al., 2004).”
From Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection (2017) · cites this paper as Moalem et al., 2004
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Cites
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
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Molecular mechanisms of male germ cell differentiation
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Iron and immunity: a double-edged sword.
Weiss, G. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1070.x · Cited by 317
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Association of Pulmonary Tuberculosis with Increased Dietary Iron
Gangaidzo, I. T., Moyo, V. M., Mvundura, E., Aggrey, G., Murphree, N. L., Khumalo, H., Saungweme, T., Kasvosve, I., Gomo, Z. A. R., Rouault, T., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/323203 · Cited by 191
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Are hereditary hemochromatosis mutations involved in Alzheimer disease?
Moalem, S., Percy, M. E., Andrews, D. F., Kruck, T. P. A., Wong, S., Dalton, A. J., Mehta, P. D., Fedor, B. L., & Warren, A. C. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20000703)93:1 · Cited by 112
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1 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Moalem S, Somerville MJ, O'Brien L et al. 2002 Parkinson disease and hereditary hemochromatosis mutations in a Swedish sample. Conference Proceedings of the 7th International Symposium on Metal Ions in Biology and Medicine, Saint Petersburg, Russia 7, 399-401.
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Schaible, U. E., & Kaufmann, S. H. E. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1046 · Cited by 945
Mechanisms of nutrient modulation of the immune response
Cunningham–Rundles, S., McNeeley, D. F., & Moon, A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.04.036 · Cited by 543
Iron Homeostasis and the Inflammatory Response
Wessling-Resnick, M. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104804 · Cited by 480
The western diet and lifestyle and diseases of civilization
Carrera-Bastos, P., Fontes, O'Keefe, Lindeberg, & Cordain (2011) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s16919 · Cited by 342
The role of iron homeostasis in remodeling immune function and regulating inflammatory disease
Mu, Q., Chen, L., Gao, X., Shen, S., Sheng, W., Min, J., & Wang, F. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.02.010 · Cited by 232
Metadata
- Authors
- Moalem, S., Weinberg, E. D., & Percy, M. E.
- Affiliations
- University of Toronto (CA)
- Indiana University (US)
- Corresponding author
- Moalem, Sharon
- Venue
- BioMetals
- Published
- 2004-04
- Volume
- 17
- Issue
- 2
- Pages
- 135-139
- ISSN
- 0966-0844 (ISSN-L)
- 1572-8773
- OpenAlex
- W1983507232
- Cited by
- 66
- References
- 32
- Citations by year
- 2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- BioMetals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- hereditary hemochromatosis, iron overload, Yersinia, intracellular bacterial pathogens, infection resistance, chlamydia, Coxiella, Francisella, Legionella, Mycobacterium, Salmonella, coronary artery disease, iron supplementation, acute phase response
- MeSH terms
- Bacterial Infections, Coronary Disease, Hemochromatosis, Humans, Iron, Macrophages, Siderosis
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