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Waist Circumference and Testosterone Levels in Community Dwelling Men. The Tromsø Study

Svartberg, Johan, von Mühlen, Denise, Sundsfjord, Johan, Jorde, Rolf·2004·European Journal of Epidemiology
DOI 10.1023/b:ejep.0000036809.30558.8f
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Abstract

To examine the relationship of total and free testosterone and sex hormone-binding globulin (SHBG) with central obesity in men, we studied 1548 men aged 25-84 years that took part in the 1994--1995 survey of the Tromsø study. Total testosterone and SHBG were measured by immuno-assay and the free testosterone fraction was calculated. These measurements were analyzed in relation to anthropometric data and lifestyle factors. The age-adjusted correlation between waist circumference (WC) and total testosterone was -0.34 (p or = 102 cm had significantly lower levels of total testosterone and SHBG compared to men with an optimal WC, defined as < 94 cm (12.3 vs. 13.9 nmol/l; p < 0.01 and 48.5 vs. 55.1 nmol/l; p < 0.001, respectively). The lowest levels of total and free testosterone were observed in men with relatively high WC despite relatively low overall obesity (BMI), suggesting that WC should be the preferred anthropometric measurement in predicting endogenous testosterone levels.

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References 42 · Cited by 229

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  1. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 2001; 86: 724–731. · DOI · Paper page
  2. Vermeulen A, Goemaere S, Kaufman JM. Testosterone, body composition and aging. J Endocrinol Invest 1999; 22: 110–116.
  3. Lahti-Koski M, Pietinen P, MännistöS, Vartiainen E. Trends in waist-to-hip ratio and its determinants in adults in Finland from 1987 to 1997. Am J Clin Nutr 2000; 72: 1436–1444. · DOI
  4. Larsson B, Svärdsudd K, Welin L, Wilhelmsen L, Björntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J 1984; 288: 1401–1404. · DOI
  5. Björntorp P. Male fat distribution and cardiovascular risk. Blood Press Suppl 1992; 4: 17–19.
  6. Barrett-Connor E. Testosterone and risk factors for cardiovascular disease in men. Diabete Metab 1995; 21: 156–161.
  7. Zmuda JM, Cauley JA, Kriska A, Glynn NW, Gutai JP, Kuller LH. Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. Am J Epidemiol 1997; 146: 609–617. · DOI
  8. Hak AE, Witteman JC, de Jong FH, Geerlings MI, Hofman A, Pols HA. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: The Rotterdam Study. J Clin Endocrinol Metab 2002; 87: 3632–3639. · DOI
  9. Seidell JC, Björntorp P, Sjöström L, Kvist H, Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose and c-peptide levels, but negatively with testosterone levels. Metabolism 1990; 39: 897–901. · DOI · Paper page
  10. Pasquali R, Casimirri F, Cantebelli S, et al. Effect of obesity and body fat distribution on sex hormones and insulin in men. Metabolism 1991; 40: 101–104. · DOI
  11. Couillard C, Gagnon J, Bergeron J, et al. Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: The HERITAGE Family Study. J Clin Endocrinol Metab 2000; 85: 1026–1031.
  12. Abate N, Haffner SM, Garg A, Peshock RM, Grundy SM. Sex steroid hormones, upper body obesity, and insulin resistance.J Clin Endocrinol Metab 2002; 87: 4522–4527. · DOI · Paper page
  13. Haffner SM, Valdez RA, Stern MP, Katz MS. Obesity, body fat distribution and sex hormones in men. Int J Obes Relat Metab Disord 1993; 17: 643–649.
  14. Khaw KT, Barrett-Connor E. Lower endogenous androgens predict central adiposity in men. Ann Epidemiol 1992; 2: 675–682. · DOI
  15. World Health Organization. Obesity: Preventing and managing the global epidemic. WHO Technical Report Series 2000; 894: 1–253.
  16. Bolelli G, Muti P, Micheli A, et al. Validity for epidemiological studies of long-term cryconservation of steroid and protein hormones in serum and plasma. Cancer Epidemiol Biomarkers Prev 1995; 4: 509–513.
  17. Kley HK, Schlaghecke R, Kruskemper HL. Stability of steroid in plasma over a 10-year period. J Clin Chem Clin Biochem 1985; 23: 875–878.
  18. Morley JE, Patrick P, Perry 3rd. HM. Evaluation of assays available to measure free testosterone. Metabolism 2002; 51: 554–559. · DOI · Paper page
  19. Seidell JC, Cigolini M, Deslypere JP, Charzewska J, Ellsinger BM, Cruz A. Body fat distribution in relation to physical activity and smoking habits in 38-year-old European men. The European Fat Distribution Study. Am J Epidemiol 1991; 133: 257–265.
  20. Winters SJ, Troen P. Episodic luteinizing hormone (LH) secretion and the response of LH and folliclestimulating hormone to LH-releasing hormone in aged men: Evidence for coexistent primary testicular insuf-ficiency and an impairment in gonadotropin secretion. J Clin Endocrinol Metab 1982; 55: 560–565. · DOI
  21. Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A. Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J Clin Endocrinol Metab 1987; 64: 68–73. · DOI
  22. Mårin P, Arver S. Androgens and abdominal obesity. Baillieres Clin Endocrinol Metab 1998; 12: 441–451. · DOI
  23. Zumoff B, Strain GW, Miller LK, et al. Plasma free and non-sex-hormone-binding-globulin-bound testosterone are decreased in obese men in proportion to their degree of obesity. J Clin Endocrinol Metab 1990; 71: 929–931. · DOI · Paper page
  24. Pasquali R, Casimirri F, Melchionda N, et al. Weight loss and sex steroid metabolism in massively obese man. J Endocrinol Invest 1988; 11: 205–210. · DOI
  25. Pasquali R, Vicennati V, Scopinaro N, et al. Achievement of near-normal body weight as the prerequisite to normalize sex hormone-binding globulin concentration in massively obese men. Int J Obes 1997; 21: 1–5. 662 · DOI
  26. Björntorp P. The regulation of adipose tissue distribution in humans.Int J Obes 1996; 20: 291–302.
  27. Pasquali R, Casimirri F, De Iasio R, et al. Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. J Clin Endocrinol Metab 1995; 80: 654–658.
  28. Cohen PG. Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med Hypothesis 2001; 56: 702–708. · DOI · Paper page
  29. Vermeulen A, Kaufman JM, Goemaere S, van Pottelberg I. Estradiol in elderly men. Aging Male 2002; 5: 98–102. · DOI · Paper page
  30. Han TS, Lean MEJ. Self-reported waist circumference compared with the 'Waist Watcher' tape-measure to identify individuals at increased health risk through intra-abdominal fat accumulation. Br J Nutr 1998; 80: 81–88. · DOI
  31. Lean MEJ, Han TS, Deurenberg P. Predicting body composition by densiometry from simple anthropometric measurements. Am J Clin Nutr 1996; 63: 4–14. · DOI
  32. Lemieux S, Prud'homme D, Bouchard C, Tremblay A, Despr ès JP. A single threshold value of waist girth identifies normal-weight and overweight subjects with excess visceral adipose tissue. Am J Clin Nutr 1996; 64: 685–693. · DOI
  33. Han TS, McNeill G, Seidell JC, Lean MEJ. Predicting intra-abdominal fatness from anthropometric measures: The influence of stature. Int J Obes Relat Metab Disord 1997; 21: 587–593. · DOI

Metadata

Authors
Svartberg, J., von Mühlen, D., Sundsfjord, J., & Jorde, R.
Affiliations
  • University Hospital of North Norway (NO)
  • University of California San Diego (US)
Corresponding author
Svartberg, Johan
ORCID
Jorde, Rolf
Venue
European Journal of Epidemiology
Publisher
Springer Science and Business Media LLC
Published
2004-07
Volume
19
Issue
7
Pages
657-663
ISSN
  • 0393-2990 (ISSN-L)
  • 1573-7284
DOI
10.1023/b:ejep.0000036809.30558.8f
OpenAlex
W2089401583
Cited by
229
References
42
Citations by year
2026: 4 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 7 · 2014: 17 · 2013: 14 · 2012: 18
FWCI
4.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
waist circumference, testosterone, free testosterone, sex hormone-binding globulin, abdominal obesity, men, anthropometric measures, body mass index, waist-to-hip ratio, endogenous sex hormones, lifestyle factors
MeSH terms
Adult, Aged, Aged, 80 and over, Anthropometry, Humans, Immunoassay, Male, Middle Aged, Norway, Population Surveillance, Surveys and Questionnaires, Sex Hormone-Binding Globulin, Testosterone

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