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Cited by 111Phase Equilibria and ThermodynamicsProtein purification and stabilityMicroencapsulation and Drying Processes

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Stabilization of Proteins in Dry Powder Formulations Using Supercritical Fluid Technology

Jovanović, Nataša, Bouchard, Andréanne, Hofland, Gerard W., Witkamp, Geert-Jan, Crommelin, Daan J. A., Jiskoot, Wim·2004·Pharmaceutical Research
DOI 10.1023/b:pham.0000048185.09483.e7
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Abstract

Therapeutic proteins have become essential in the treatment of many diseases. Their formulation in dry form is often required to improve their stability. Traditional freeze-drying or spray-drying processes are often harmful to labile proteins and could be replaced by supercritical fluid (SCF) drying to produce particles with defined physicochemical characteristics in a mild single step. A survey of the current SCF drying processes for proteins is presented to give insight into the effect of SCF drying on protein stability and to identify issues that need further investigation. Methods used for drying aqueous and organic protein solutions are described. In particular, effects of process and formulation parameters on particle formation and protein stability are discussed. Although SCF methodology for drying proteins is still in its infancy, it can provide a serious alternative to existing drying methods for stabilizing proteins.

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Crossref · 10.1023/b:pham.0000048185.09483.e7

Cites

54 of 54 references verified0 citation errors · 0 not checkable

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  • Supercritical drying techniques have been shown to be feasible for other macromolecular biotech products, such as proteins.

    “they have been shown to be feasible –with their pros and cons– for other macromolecular biotech products, such as proteins (Jovanović et al., 2004).”

    From mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability (2021) · cites this paper as Jovanović et al., 2004

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 19

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  3. R. Thiering, F. Dehghani, and N. R. Foster. Micronization of model proteins using compressed carbon dioxide, Proceedings of the 5th International Symposium on Supercritical Fluids, Atlanta, 2000.
  4. N. Elvassore, A. Bertucco, and P. Caliceti. Production of protein-polymer micro-capsules by supercritical anti-solvent techniques, Proceedings of the 5th International Symposium on Supercritical Fluids, Atlanta, 2000.
  5. J. Jung, F. Leboeuf, and M. Perrut. Preparation of inhalable protein particles by SCF-emulsion drying, Proceedings of the 6th International Symposium on Supercritical Fluids, Vol. 3, Versailles, France, 2003, pp. 1837–1842.
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  8. H. C. Pellikaan and F. E. Wubbolts. Nozzle construction for particle formation using supercritical anti solvent precipitation, Proceedings of the 6th International Symposium on Supercritical Fluids, Vol. 3, Versailles, France, 2003, pp. 1765–1770.
  9. N. R. Foster, F. Dehghani, R. T. Bustami, and H.-K. Chan. Generation of lysozyme-lactose powders using the ASES process, Proceedings of the 6th International Symposium on Supercritical Fluids, Vol. 3, Versailles, France, 2003, pp. 1831–1836.
  10. R. E. Sievers, B. A. Miles, S. P. Sellers, P. D. Milewski, and K. D. Kusek. New process for manufacture of 1-micron spherical drug particles by CO2-assisted nebulization of aqueous solutions, Proceedings of Respiratory Drug Delivery VI, South Carolina, 1998, pp. 417–419.
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  12. J. W. Mullin. Crystallization, Oxford Butterworth-Heinemann, 1993.
  13. R. T. Bustami and H.-K. Chan. Generation of protein micro-particles using high pressure modified carbon dioxide, Proceedings of the 5th International Symposium on Supercritical Fluids, Atlanta, 2000.
  14. R. T. Forbes, R. Sloan, I. Kibria, M. E. Hollowood, G. O. Humphreys, and P. York. Production of stable protein particles: a comparison of freeze, spray and supercritical drying, Proceedings of the World Congress on Particle Technology 3, Brighton, UK, 1998.
  15. R. Sloan, M. E. Hollowood, G. O. Humphreys, W. Ashraf, and P. York. Supercritical fluid processing: Preparation of stable protein particles, Proceedings of the 5th Meeting on Supercritical Fluids, Nice, France, 1998, pp. 301–306.
  16. R. Thiering, F. Dehghani, A. Dillow, and N. R. Foster. Solvent effects on the controlled dense gas precipitation of model proteins. J. Chem. Technol. Biotechnol. 75:42–53 (2000). · DOI
  17. G. Del Re and G. Di Giacomo. Microparticles production from aqueous solutions using gas antisolvent process, Proceedings of the 8th Meeting on Supercritical Fluids, Bordeaux, France, 2002, pp. 85–90.
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Metadata

Authors
Jovanović, N., Bouchard, A., Hofland, G. W., Witkamp, G.-J., Crommelin, D. J. A., & Jiskoot, W.
Affiliations
  • Utrecht University (NL)
  • Delft University of Technology (NL)
Corresponding author
Jiskoot, Wim
ORCID
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
2004-11
Volume
21
Issue
11
Pages
1955-1969
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1023/b:pham.0000048185.09483.e7
OpenAlex
W2054260828
Cited by
111
References
54
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 4
FWCI
7.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Phase Equilibria and Thermodynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
Keywords
supercritical drying, protein stabilization, therapeutic proteins, dry powder formulation, freeze-drying alternative, particle formation, protein stability, formulation parameters
MeSH terms
Carbon Dioxide, Chemistry, Pharmaceutical, Desiccation, Powders, Proteins, Solutions

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