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Effects of ovariectomy and estrogen on skeletal muscle function in growing rats
Abstract
This study examined the effect of estrogen replacement on soleus muscle size and contractile function in ovariectomized rats during physiological growth. Seven week old female Sprague-Dawley rats were assigned to one of three treatment groups: (1) control animals (SHAM), (2) ovariectomized animals without estrogen replacement (OVX/CO), and (3) ovariectomized animals with 17 beta-estradiol replacement (OVX/E2). OVX/CO and OVX/E2 animals were pair-fed to SHAM animals to rule out the potentially confounding effect of differences in food intake. Rats were sacrificed 4 weeks after surgery and the soleus muscle was removed for analysis. Estrogen replacement reduced body weight, relative body weight gain, and soleus muscle fiber size despite all groups having a similar food intake. Ovariectomy alone had no effect on any of these parameters suggesting that estrogen may inhibit skeletal muscle growth when it is the only ovarian hormone present. Neither ovariectomy nor estrogen replacement affected maximal specific isometric force. Estrogen replacement increased half relaxation time. Ovariectomy resulted in a reduction in time to peak tension that was reversed with estrogen replacement. This reduction was not accompanied by a change in myosin heavy chain composition implying that calcium handling may have been altered. Results from this study suggest that estrogen affects skeletal muscle growth and twitch kinetics.
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“OVX induces a reduction in time to peak tension and increases time to 50% relaxation in rats, whereas estrogen replacement reverses the OVX-induced reduction in peak tension (62).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [62]
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Metadata
- Authors
- McCormick, K. M., Burns, K. L., Piccone, C. M., Gosselin, L. E., & Brazeau, G. A.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- McCormick, Kathleen M.
- ORCID
- Brazeau, Gayle A.
- Venue
- Journal of Muscle Research & Cell Motility
- Published
- 2004-02
- Volume
- 25
- Issue
- 1
- Pages
- 21-27
- ISSN
- 0142-4319 (ISSN-L)
- 1573-2657
- OpenAlex
- W1994232632
- Cited by
- 102
- References
- 40
- Citations by year
- 2026: 5 · 2025: 3 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 10 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Muscle Research and Cell Motility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- estrogen replacement therapy, ovariectomy, skeletal muscle growth, soleus muscle, estradiol, muscle fiber size, muscle contractility, twitch kinetics, half-relaxation time, myosin heavy chain, calcium handling, female rats
- MeSH terms
- Animals, Body Weight, Eating, Estradiol, Estrogens, Female, Muscle Contraction, Organ Size, Ovariectomy, Time Factors, Uterus, Rats, Sprague-Dawley, Muscle, Skeletal, Muscle Fibers, Skeletal, Myosin Heavy Chains, Rats, In Vitro Techniques
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