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Cited by 62Estrogen and related hormone effectsMuscle Physiology and DisordersHormonal and reproductive studies

Long-term effects of estrogen on rat skeletal muscle

Suzuki, S., Yamamuro, T.·1985·Experimental Neurology
DOI 10.1016/0014-4886(85)90219-5
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Abstract

The long-term effects of estrogen on the development of rat extensor digitorum longus (EDL) and soleus (SOL) muscles were examined using physiological and histochemical methods. The rats were in three groups: group 1, ovariectomized; group 2, sham-operated; and group 3, ovariectomized followed by estradiol administration. Isometric twitch and tetanic tensions of both the EDL and SOL obtained from 10-week-old rats were evoked by electrical stimulation. The isometric twitch tensions of the EDL in groups 2 and 3 were significantly lower than in group 1, however, there was no significant differences in isometric twitch tensions of the SOL among the three groups. The isometric tetanic tensions of the EDL in groups 2 and 3 were also significantly lower than in group 1, and the isometric tetanic tension of the SOL in group 3 was significantly lower than in group 1. There were no changes in the total number of muscle fibers or in the ratios of fiber types. But the mean fiber diameter of all fiber types (particularly in types IIA and IIB) was significantly lower in group 3 than in groups 1 and 2. Therefore, the possibility that estrogen may play an inhibitory role in the development of skeletal muscle fibers has to be considered.

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Crossref · 10.1016/0014-4886(85)90219-5

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  • In rat soleus and EDL muscles, OVX leads to a slight increase in the mean fiber diameter of type-I, -IIA, and -IIB fibers. Estrogen supplementation decreases fiber diameter in all fiber types in both the soleus and EDL significantly from OVX levels to below baseline levels.

    “In rat soleus and EDL muscles, OVX leads to a slight increase in the mean fiber diameter of type-I, -IIA, and -IIB fibers. Estrogen supplementation decreases fiber diameter in all fiber types in both the soleus and EDL significantly from OVX levels to below baseline levels (90).”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [90]

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Authors
Suzuki, S., & Yamamuro, T.
Affiliations
Kyoto University (JP)
Corresponding author
Suzuki, S.
ORCID
Suzuki, S.
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
1985-02
Volume
87
Issue
2
Pages
291-299
ISSN
0014-4886 (ISSN-L)
DOI
10.1016/0014-4886(85)90219-5
OpenAlex
W2040561275
Cited by
62
References
29
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2021: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2015: 2 · 2014: 2 · 2013: 2
FWCI
0.75
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
estrogen, skeletal muscle development, estradiol, ovariectomy, extensor digitorum longus, soleus muscle, isometric twitch tension, tetanic tension, muscle fiber diameter, muscle fiber composition, muscle fiber number, rats
MeSH terms
Animals, Estrogens, Female, Muscles, Rats, Inbred Strains, Rats

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