Beneficial effect of vitamin E on the metabolic parameters of diabetic rats
Abstract
The role of vitamin E in the pathogenesis of diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin E on some of the metabolic parameters of experimental diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (60 mg/kg body weight at 12 weeks of age). Vitamin E (0.2, 0.4, 0.8 mg/kg body weight) was administered orally for a period of 3 weeks to normal and diabetic Wistar rats. In some experiments, Vitamin E was given either before or after the induction of diabetes mellitus. Blood glucose level and weight were recorded for each rat in different groups on a weekly basis. Oral glucose tolerance test (OGTT) was performed on fasted normal, diabetic and vitamin E treated rats at the end of the experiment. Vitamin E significantly (p < 0.01) reduced blood glucose levels in experimental diabetes mellitus at all doses as compared to untreated rats. Vitamin E induced weight loss in normal as well as in diabetic rats. The beneficial effect of vitamin E on the hyperglycaemia of diabetic rats was dose-dependent. Moreover, vitamin E also improved OGTT in diabetic rats compared to untreated diabetics. In conclusion, vitamin E may play a role in glucose metabolism and thus be a useful adjuvant therapy in type I diabetes.
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Vitamin E significantly reduces blood glucose in diabetic rats compared to untreated, and the effect is dose-dependent.
“It has been shown that vitamin E significantly reduced glucose levels in the blood compared to untreated rats. The beneficial effect of vitamin E on the hyperglycemic diabetic rats was found to be dose-dependent.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Al Shamsi et al. 2004
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
A REVIEW ON ROLE OF ANTIOXIDANTS IN DIABETES
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- Authors
- Al Shamsi, M. S., Amin, A., & Adeghate, E.
- Affiliations
- United Arab Emirates University (AE)
- Corresponding author
- Adeghate, Ernest
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2004-06
- Volume
- 261
- Issue
- 1
- Pages
- 35-42
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W1986942886
- Cited by
- 53
- References
- 35
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 11 · 2022: 10 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Keywords
- vitamin E, diabetes mellitus, streptozotocin-induced diabetes, blood glucose, glucose tolerance, hyperglycemia, weight loss, glucose metabolism, type 1 diabetes, adjuvant therapy, dose-dependent effects
- MeSH terms
- Animals, Antioxidants, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Glucose Tolerance Test, Male, Vitamin E, Rats, Wistar, Rats
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