Cited by 122Origins and Evolution of LifePhilosophy of Biology and Scientific ExplanationEvolution and Genetic Dynamics

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Causation and the Origin of Life. Metabolism or Replication First?

Pross, Addy·2004·Origins of life and evolution of the biosphere

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Abstract

The conceptual gulf that separates the 'metabolism first' and 'replication first' mechanisms for the emergence of life continues to cloud the origin of life debate. In the present paper we analyze this aspect of the origin of life problem and offer arguments in favor of the 'replication first' school. Utilizing Wicken's two-tier approach to causation we argue that a causal connection between replication and metabolism can only be demonstrated if replication would have preceded metabolism. In conjunction with existing empirical evidence and theoretical reasoning, our analysis concludes that there is no substantive evidence for a 'metabolism first' mechanism for life's emergence, while a coherent case can be made for the 'replication first' group of mechanisms. The analysis reaffirms our conviction that life is an extreme expression of kinetic control, and that the emergence of metabolic pathways can be understood by considering life as a manifestation of 'replicative chemistry'.

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Authors: Pross, A.
Affiliations: Ben-Gurion University of the Negev (IL)
Corresponding author: Pross, Addy
ORCID: Pross, Addy
Venue: Origins of life and evolution of the biosphere
Publisher: Springer Science and Business Media LLC
Published: 2004-06
Volume: 34
Issue: 3
Pages: 307-321
ISSN: 0169-6149 (ISSN-L)
1573-0875
DOI: 10.1023/b:orig.0000016446.51012.bc
OpenAlex: W2111124146
Cited by: 122
References: 49
Citations by year: 2026: 6 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 10
FWCI: 3.34
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Origins of Life and Evolution of Biospheres (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: origin of life, metabolism-first hypothesis, causality, kinetic control, prebiotic chemistry
MeSH terms: Origin of Life, Energy Metabolism, Reproduction, Thermodynamics, Life, Evolution, Chemical

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Causation and the Origin of Life. Metabolism or Replication First?

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