The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
“Programmed Polymeric Devices” for Pulsed Drug Delivery
Abstract
Pharmaceutical research strives to design drug delivery systems that respond to therapeutic needs. Considering the facts that physiologic parameters (e.g., heart rate, blood pressure, and plasma concentration of hormones, plasma proteins, and enzymes) display constancy over time, drug delivery systems with a constant release profile have been designed. However, because of circadian rhythms in physiologic parameters and pathologic conditions (e.g., asthma, angina pectoris), the conventional paradigm concerning drug concentrations "the flatter the better" may not be what the organism may need. Instead, to correlate with our biological needs, "precisely timed drug delivery," which could be accomplished with "programmable dosage forms," is required. Precisely timed drug delivery may maximize therapeutic efficacy, may minimize dose frequency, and may reduce toxicity by avoiding side effects and drug tolerance. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical devices.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“PLGA is also an attractive candidate for devices with multi-drug delivery and multi-pulsed delivery applications because of its desirable and tunable properties [62–65].”
From Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier (2011) · cites this paper as [64]
In the citing paper
“Novel multi-pulsatile delivery devices have developed in which there is a predetermined off period followed by rapid and transient drug release in a cycle until the device is degraded.”
From Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier (2011) · cites this paper as [64]
Citations
Cites
Mechanisms of polymer degradation and erosion
Göpferich, A. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85755-3 · Cited by 1,781
Responsive polymeric delivery systems
Kost, J., & Langer, R. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00136-8 · Cited by 747
Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide)
Zhu, G., Mallery, S. R., & Schwendeman, S. P. (2000) · Nature Biotechnology · doi:10.1038/71916 · Cited by 621
Biodegradable microspheres as a vaccine delivery system
Eldridge, J. H., Staas, J. K., Meulbroek, J. A., McGhee, J. R., Tice, T. R., & Gilley, R. M. (1991) · Molecular Immunology · doi:10.1016/0161-5890(91)90076-v · Cited by 397
Stimulus-Responsive “Smart” Hydrogels as Novel Drug Delivery Systems
Soppimath, K. S., Aminabhavi, T. M., Dave, A. M., Kumbar, S. G., & Rudzinski, W. E. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120006428 · Cited by 389
Osmotic drug delivery: a review of the patent literature
Santus, G., & Baker, R. W. (1995) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00013-x · Cited by 231
Determinants of Release Rate of Tetanus Vaccine from Polyester Microspheres
Alonso, M. J., Cohen, S., Park, T. G., Rk, G., Siber, G. R., & Langer, R. (1993) · Pharmaceutical Research · doi:10.1023/a:1018942118148 · Cited by 223
Pulsed and Self-Regulated Drug Delivery
Kost, J. (1990) · Cited by 200
Thomasin, C., Corradin, G., Men, Y., Merkle, H. P., & Gander, B. A. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(96)01363-6 · Cited by 188
Effect of Ca2+-alginate gel dissolution on release of dextran with different molecular weights
Kikuchi, A., Kawabuchi, M., Watanabe, A., et al. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00141-2 · Cited by 179
Cited by
Sorted by citations
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
Makadia, H. K., & Siegel, S. J. (2011) · Polymers · doi:10.3390/polym3031377 · Cited by 4,816
“Such systems can be extended to achieve programmed delivery of multiple drugs in a predetermined sequence of pulses from a single device [64].”
Background
Metadata
- Authors
- Stubbe, B. G., De Smedt, S. C., & Demeester, J.
- Affiliations
- Ghent University (BE)
- Venue
- Pharmaceutical Research
- Published
- 2004-10
- Volume
- 21
- Issue
- 10
- Pages
- 1732-1740
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2000186730
- Cited by
- 84
- References
- 53
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2013: 4 · 2012: 5
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- circadian rhythm, controlled release, drug release profile, treatment efficacy, drug tolerance
- MeSH terms
- Drug Implants, Enzymes, Hydrolysis, Osmotic Pressure, Polymers, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
