The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
“Programmed Polymeric Devices” for Pulsed Drug Delivery
Abstract
Pharmaceutical research strives to design drug delivery systems that respond to therapeutic needs. Considering the facts that physiologic parameters (e.g., heart rate, blood pressure, and plasma concentration of hormones, plasma proteins, and enzymes) display constancy over time, drug delivery systems with a constant release profile have been designed. However, because of circadian rhythms in physiologic parameters and pathologic conditions (e.g., asthma, angina pectoris), the conventional paradigm concerning drug concentrations "the flatter the better" may not be what the organism may need. Instead, to correlate with our biological needs, "precisely timed drug delivery," which could be accomplished with "programmable dosage forms," is required. Precisely timed drug delivery may maximize therapeutic efficacy, may minimize dose frequency, and may reduce toxicity by avoiding side effects and drug tolerance. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical devices.
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“PLGA is also an attractive candidate for devices with multi-drug delivery and multi-pulsed delivery applications because of its desirable and tunable properties [62–65].”
From Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier (2011) · cites this paper as [64]
In the citing paper
“Novel multi-pulsatile delivery devices have developed in which there is a predetermined off period followed by rapid and transient drug release in a cycle until the device is degraded.”
From Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier (2011) · cites this paper as [64]
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Cited by
Sorted by citations
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
Makadia, H. K., & Siegel, S. J. (2011) · Polymers · doi:10.3390/polym3031377 · Cited by 4,816
“Such systems can be extended to achieve programmed delivery of multiple drugs in a predetermined sequence of pulses from a single device [64].”
Background
Metadata
- Authors
- Stubbe, B. G., De Smedt, S. C., & Demeester, J.
- Affiliations
- Ghent University (BE)
- Venue
- Pharmaceutical Research
- Published
- 2004-10
- Volume
- 21
- Issue
- 10
- Pages
- 1732-1740
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2000186730
- Cited by
- 84
- References
- 53
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2013: 4 · 2012: 5
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- circadian rhythm, controlled release, drug release profile, treatment efficacy, drug tolerance
- MeSH terms
- Drug Implants, Enzymes, Hydrolysis, Osmotic Pressure, Polymers, Drug Delivery Systems
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