Mechanisms of polymer degradation and erosion
Abstract
The most important features of the degradation and erosion of degradable polymers in vitro are discussed. Parameters of chemical degradation, which is the scission of the polymer backbone, are described such as the type of polymer bond, pH and copolymer composition. Examples are given how these parameters can be used to control degradation rates. Degradation leads finally to polymer erosion, the loss of material from the polymer bulk. The resulting changes in morphology, pH, oligomer and monomer properties as well as crystallinity are illustrated with selected examples. Finally, a brief survey on approaches to polymer degradation and erosion is given.
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For aliphatic polyesters like PLA-b-PEG-b-PLA, the main degradation process is hydrolysis of ester links.
“For aliphatic polyesters like PLAb -PEGb -PLA, the main degradation process is the hydrolysis of ester links.”
From Mechanical behaviour׳s evolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation (2016) · cites this paper as Göpferich, 1996
Chain cleavage during hydrolysis decreases molar mass and generates an evolution of mechanical properties.
“The chain cleavage comes with the decrease of molar mass and generates an evolution of mechanical properties.”
From Mechanical behaviour׳s evolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation (2016) · cites this paper as Göpferich, 1996
Hydrolysis of ester links in aliphatic polyesters starts when water diffuses into the polymer bulk, causing swelling; the reaction cleaves ester links into oligomers and monomers, which are released causing mass loss and erosion.
“It starts when water diffuses into the polymer bulk leading to a swelling. The hydrolysis reaction cleaves the ester links in polymeric bonds leading to the creation of oligomers and monomers. Then, these monomers are released out of the polymer bulk causing characteristic mass loss and material erosion (Göpferich, 1996).”
From Mechanical behaviour׳s evolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation (2016) · cites this paper as Göpferich, 1996
When polymeric structure thickness is important, an autocatalytic process can appear, accelerating local degradation by generating carboxylic acid monomers that stay locked in the polymeric matrix and lower surrounding pH.
“When the polymeric structure thickness is important, an autocatalytic process can appear, accelerating local degradation. It generates carboxylic acids monomers, which stay locked in the polymeric matrix, lowering surrounding pH (Göpferich, 1996).”
From Mechanical behaviour׳s evolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation (2016) · cites this paper as Göpferich, 1996
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- Authors
- Göpferich, A.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Göpferich, Achim
- ORCID
- Göpferich, Achim
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 17
- Issue
- 2
- Pages
- 103-114
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2072624182
- Cited by
- 1,781
- References
- 115
- Citations by year
- 2026: 57 · 2025: 42 · 2024: 58 · 2023: 83 · 2022: 94 · 2021: 89 · 2020: 104 · 2019: 94 · 2018: 76 · 2017: 101 · 2016: 102 · 2015: 86 · 2014: 86 · 2013: 85 · 2012: 81
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- polymer degradation, polymer erosion, degradable polymers, chemical degradation, copolymer composition, pH-dependent degradation, degradation rate control, morphology (materials science), crystallinity, oligomers, monomers
- MeSH terms
- Biocompatible Materials, Hydrogen-Ion Concentration, Kinetics, Microscopy, Electron, Scanning, Models, Chemical, Particle Size, Polymers, Structure-Activity Relationship, Water, Porosity, In Vitro Techniques
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