The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest
Open accessAbstract
Expiratory flow limitation promotes dynamic hyperinflation during exercise in chronic obstructive pulmonary disease (COPD) patients with a consequent reduction in inspiratory capacity (IC), limiting their exercise tolerance. Therefore, the exercise capacity of patients with tidal expiratory flow limitation (FL) at rest should depend on the magnitude of IC. The presented study was designed to evaluate the role of FL on the relationship between resting IC, other respiratory function variables and exercise performance in COPD patients. Fifty-two patients were included in the study. Negative expiratory pressure (NEP) uptake (VO2,max) were measured during an incremental symptom-limited cycle exercise. Twenty-nine patients were FL at rest. The IC was normal in all non-FL patients, while in most FL subjects it was decreased. Both WRmax and VO2,max were lower in FL patients (p<0.001, each). A close relationship of WRmax and O2,max to IC was found (r=0.73 and 0.75, respectively; p<0.0001, each). In the whole group, stepwise regression analysis selected IC and forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) (% predicted) as the only significant contributors to exercise tolerance. Subgroup analysis showed that IC was the sole predictor in FL patients, and FEV1/FVC in non-FL patients. Detection of flow limitation provides useful information on the factors that influence exercise capacity in chronic obstructive pulmonary disease patients. Accordingly, in patients with flow limitation, inspiratory capacity appears as the best predictor of exercise tolerance, reflecting the presence of dynamic hyperinflation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Work from other groups supports these results by showing a significant correlation between resting IC and peak work rate and peak oxygen uptake, particularly in patients with demonstrable expiratory flow limitation at rest.88”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [88]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Standardization of Spirometry, 1994 Update. American Thoracic Society
(1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.3.7663792 · Cited by 6,605
Lung volumes and forced ventilatory flows
Quanjer, P. H., Tammeling, G. J., Cotes, J. E., Pedersen, O. F., Peslin, R., & Yernault, J. (1993) · European Respiratory Journal · doi:10.1183/09041950.005s1693 · Cited by 5,531
(1993) · PubMed · Cited by 3,827
Lung Function Testing: Selection of Reference Values and Interpretative Strategies
(1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.5.1202 · Cited by 2,508
Standardization of Spirometry—1987 Update
(1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1285 · Cited by 2,326
Changes in the normal maximal expiratory flow-volume curve with growth and aging.
Knudson, R. J., Lebowitz, M. D., Holberg, C. J., & Burrows, B. A. (1983) · PubMed · doi:10.1164/arrd.1983.127.6.725 · Cited by 1,913
A Stagewise Rejective Multiple Test Procedure Based on a Modified Bonferroni Test
Hommel, G. (1988) · Biometrika · doi:10.1093/biomet/75.2.383 · Cited by 1,367
Weisman, I. M., & Zeballos, R. J. (1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80065-8 · Cited by 1,217
Peripheral Muscle Weakness Contributes to Exercise Limitation in COPD
Gosselink, R., Troosters, T., & Decramer, M. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630582 · Cited by 1,024
Hamilton, A., Killian, K. J., Summers, E., & Jones, N. L. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.6.8520771 · Cited by 570
O'Donnell, D. E., & Webb, K. A. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.5.1351 · Cited by 543
O'DONNELL, D. E., LAM, M., & WEBB, K. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.2.9901038 · Cited by 485
A simple method to detect expiratory flow limitation during spontaneous breathing
Koulouris, N. G., Valta, P., Lavoie, A., Corbeil, C., Chasse, M., Braidy, J., & Milic‐Emili, J. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08020306 · Cited by 249
Determinants of Maximal Inspiratory Pressure: The Baltimore Longitudinal Study of Aging
Harik-Khan, R., Wise, R. A., & Fozard, J. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.5.9712006 · Cited by 242
Control of Breathing in Patients with Chronic Obstructive Lung Disease
Sorlí, J. V., Grassino, A. E., Lorange, G., & Milic‐Emili, J. (1978) · Clinical Science · doi:10.1042/cs0540295 · Cited by 220
Effect of salbutamol on dynamic hyperinflation in chronic obstructive pulmonary disease patients
Tantucci, C., Duguet, A., Similowski, T., Zelter, M., Derenne, J., & Milic‐Emili, J. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.12040799 · Cited by 212
Exercise tolerance in chronic airway obstruction.
Jones, N. L., Jones, G., & Edwards, R. H. T. (1971) · PubMed · doi:10.1164/arrd.1971.103.4.477 · Cited by 174
Detection of Expiratory Flow Limitation During Mechanical Ventilation
Valta, P., Corbeil, C., Lavoie, A., Campodonico, R., Koulouris, N. G., Chassé, M., Braidy, J., & Milic‐Emili, J. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.5.7952558 · Cited by 170
Detection of expiratory flow limitation during exercise in COPD patients
Koulouris, N. G., Dimopoulou, I., Valta, P., Finkelstein, R., Cosío, M. G., & Milic‐Emili, J. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.3.723 · Cited by 160
Lisboa, C., Munoz, V., Beroíza, T., Leiva, A., & Cruz, E. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07071266 · Cited by 120
Self-citationMechanisms by Which COPD Affects Exercise Tolerance
Bauerle, O., Chrusch, C., & Younes, M. K. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9609126 · Cited by 111
Effect of inspiratory muscle training with an intermediate load on inspiratory power output in COPD
Villafranca, C., Borzone, G. R., Leiva, A., & Lisboa, C. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.11010028 · Cited by 61
Self-citationExercise Limitation in Obstructive Lung Disease
Murariu, C., Ghezzo, H., Milic‐Emili, J., & Gautier, H. (1998) · CHEST Journal · doi:10.1378/chest.114.4.965 · Cited by 50
Self-citationBreathing pattern and hypercapnia in patients with obstructive pulmonary disease.
Parot, S., Saunier, C. G., Gautier, H., Milic‐Emili, J., & Sadoul, P. (1980) · PubMed · doi:10.1164/arrd.1980.121.6.985 · Cited by 42
Expiratory Flow Limitation in COPD Patients After Single Lung Transplantation
Murciano, D., PICHOT, M.-H., Boczkowski, J., Sleiman, C., Parienté, R., & Milic‐Emili, J. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.3.9116983 · Cited by 38
Die arteriellen Blutgaspartialdrücke und ihre Beziehungen zu Alter und anthropometrischen Grössen
Hertle, F. H., Goerg, R., & Lange, H.-J. (2009) · Respiration · doi:10.1159/000192800 · Cited by 32
DISABILITY IN PATIENTS WITH OBSTRUCTIVE PULMONARY DISEASE.
GILBERT, R., Keighley, J., & Auchincloss, J. H. (1964) · PubMed · doi:10.1164/arrd.1964.90.3.383 · Cited by 16
Flagged first, then by citations
Research works printed but not linked: 5
- Carlson DJ, Ries AL, Kaplan RM. Predicting maximal exercise tolerance in patients with COPD. Chest 1991; 100: 307±311.
- Eltayara L, Becklake MR, Volta CA, Milic-Emili J. Rel- ationship between chronic dyspnoea and expiratory flow- limitation in patients with chronic obstructive-pulmonary disease. Am J Respir Crit Care Med 1996; 154: 1726± 1734.
- Borg GAV. Psychophysical basis of perceived exertion. Med Sci Sports Exerc 1982; 14: 377±381.
- Hertle FH, Goerg R, Lange HJ. Arterial blood partial pres- sure as related to age and anthropometric data. Respiration 1971; 28: 1±30.
- Gottfried SB. The role of PEEPi in the mechanically ventilated patient. In: Roussos C, Manni JJ, eds. Ven- tilatory Failure. Berlin, Springer-Verlag, 1991; pp. 392± 418.
Cited by
Sorted by citations
Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938
American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici, L., Donner, C., Wouters, E., Zuwallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B., Engelen, M., Fahy, B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1211st · Cited by 1,966
Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease
O'DONNELL, D. E., REVILL, S. M., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2012122 · Cited by 1,076
Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
O'Donnell, D. E., Flüge, T., Gerken, F., Hamilton, A., Webb, K., Aguilaniu, B., Make, B., & Magnussen, H. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00116004 · Cited by 859
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Cazzola, M., MacNee, W., Martínez, F. J., Rabe, K. F., Franciosi, L. G., Barnes, P. J., Brusasco, V., Burge, P. S., Calverley, P. M., Celli, B. R., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00099306 · Cited by 850
Metadata
- Authors
- Diaz, O., Villafranca, C., Ghezzo, H., Borzone, G., Leiva, A., Milic-Emil, J., & Lisboa, C.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- McGill University (CA)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2000-08
- Volume
- 16
- Issue
- 2
- Pages
- 269
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2127159607
- Cited by
- 300
- References
- 27
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 10 · 2013: 12 · 2012: 19
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- chronic obstructive pulmonary disease, inspiratory capacity, exercise tolerance, dynamic hyperinflation, negative expiratory pressure, VO2max, FEV1, FEV1/FVC ratio
- MeSH terms
- Aged, Female, Forced Expiratory Volume, Forecasting, Humans, Inspiratory Capacity, Lung Diseases, Obstructive, Male, Oxygen Consumption, Physical Endurance, Pulmonary Ventilation, Rest, Tidal Volume, Vital Capacity, Exercise
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
