The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expiratory flow limitation at rest
Open accessAbstract
Expiratory flow limitation promotes dynamic hyperinflation during exercise in chronic obstructive pulmonary disease (COPD) patients with a consequent reduction in inspiratory capacity (IC), limiting their exercise tolerance. Therefore, the exercise capacity of patients with tidal expiratory flow limitation (FL) at rest should depend on the magnitude of IC. The presented study was designed to evaluate the role of FL on the relationship between resting IC, other respiratory function variables and exercise performance in COPD patients. Fifty-two patients were included in the study. Negative expiratory pressure (NEP) uptake (VO2,max) were measured during an incremental symptom-limited cycle exercise. Twenty-nine patients were FL at rest. The IC was normal in all non-FL patients, while in most FL subjects it was decreased. Both WRmax and VO2,max were lower in FL patients (p<0.001, each). A close relationship of WRmax and O2,max to IC was found (r=0.73 and 0.75, respectively; p<0.0001, each). In the whole group, stepwise regression analysis selected IC and forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) (% predicted) as the only significant contributors to exercise tolerance. Subgroup analysis showed that IC was the sole predictor in FL patients, and FEV1/FVC in non-FL patients. Detection of flow limitation provides useful information on the factors that influence exercise capacity in chronic obstructive pulmonary disease patients. Accordingly, in patients with flow limitation, inspiratory capacity appears as the best predictor of exercise tolerance, reflecting the presence of dynamic hyperinflation.
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“Work from other groups supports these results by showing a significant correlation between resting IC and peak work rate and peak oxygen uptake, particularly in patients with demonstrable expiratory flow limitation at rest.88”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [88]
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Cites
Standardization of Spirometry, 1994 Update. American Thoracic Society
(1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.3.7663792 · Cited by 6,605
Lung volumes and forced ventilatory flows
Quanjer, P. H., Tammeling, G. J., Cotes, J. E., Pedersen, O. F., Peslin, R., & Yernault, J. (1993) · European Respiratory Journal · doi:10.1183/09041950.005s1693 · Cited by 5,531
(1993) · PubMed · Cited by 3,827
Lung Function Testing: Selection of Reference Values and Interpretative Strategies
(1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.5.1202 · Cited by 2,508
Standardization of Spirometry—1987 Update
(1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1285 · Cited by 2,326
Changes in the normal maximal expiratory flow-volume curve with growth and aging.
Knudson, R. J., Lebowitz, M. D., Holberg, C. J., & Burrows, B. A. (1983) · PubMed · doi:10.1164/arrd.1983.127.6.725 · Cited by 1,913
A Stagewise Rejective Multiple Test Procedure Based on a Modified Bonferroni Test
Hommel, G. (1988) · Biometrika · doi:10.1093/biomet/75.2.383 · Cited by 1,367
Weisman, I. M., & Zeballos, R. J. (1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80065-8 · Cited by 1,217
Peripheral Muscle Weakness Contributes to Exercise Limitation in COPD
Gosselink, R., Troosters, T., & Decramer, M. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630582 · Cited by 1,024
Hamilton, A., Killian, K. J., Summers, E., & Jones, N. L. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.6.8520771 · Cited by 570
Research works printed but not linked: 5
- Carlson DJ, Ries AL, Kaplan RM. Predicting maximal exercise tolerance in patients with COPD. Chest 1991; 100: 307±311.
- Eltayara L, Becklake MR, Volta CA, Milic-Emili J. Rel- ationship between chronic dyspnoea and expiratory flow- limitation in patients with chronic obstructive-pulmonary disease. Am J Respir Crit Care Med 1996; 154: 1726± 1734.
- Borg GAV. Psychophysical basis of perceived exertion. Med Sci Sports Exerc 1982; 14: 377±381.
- Hertle FH, Goerg R, Lange HJ. Arterial blood partial pres- sure as related to age and anthropometric data. Respiration 1971; 28: 1±30.
- Gottfried SB. The role of PEEPi in the mechanically ventilated patient. In: Roussos C, Manni JJ, eds. Ven- tilatory Failure. Berlin, Springer-Verlag, 1991; pp. 392± 418.
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Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938
American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation
Nici, L., Donner, C., Wouters, E., Zuwallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B., Engelen, M., Fahy, B., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1211st · Cited by 1,966
Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease
O'DONNELL, D. E., REVILL, S. M., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2012122 · Cited by 1,076
Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
O'Donnell, D. E., Flüge, T., Gerken, F., Hamilton, A., Webb, K., Aguilaniu, B., Make, B., & Magnussen, H. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00116004 · Cited by 859
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Cazzola, M., MacNee, W., Martínez, F. J., Rabe, K. F., Franciosi, L. G., Barnes, P. J., Brusasco, V., Burge, P. S., Calverley, P. M., Celli, B. R., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00099306 · Cited by 850
Metadata
- Authors
- Diaz, O., Villafranca, C., Ghezzo, H., Borzone, G., Leiva, A., Milic-Emil, J., & Lisboa, C.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- McGill University (CA)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2000-08
- Volume
- 16
- Issue
- 2
- Pages
- 269
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2127159607
- Cited by
- 300
- References
- 27
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 10 · 2013: 12 · 2012: 19
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- chronic obstructive pulmonary disease, inspiratory capacity, exercise tolerance, dynamic hyperinflation, negative expiratory pressure, VO2max, FEV1, FEV1/FVC ratio
- MeSH terms
- Aged, Female, Forced Expiratory Volume, Forecasting, Humans, Inspiratory Capacity, Lung Diseases, Obstructive, Male, Oxygen Consumption, Physical Endurance, Pulmonary Ventilation, Rest, Tidal Volume, Vital Capacity, Exercise
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