Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals
Open accessAbstract
Elevated serum immunoglobulin (Ig)E is the hallmark of atopy, and contributes to asthma and bronchial hyperresponsiveness in atopic individuals. In contrast, the significance of IgE in nonallergic subjects is less clear. The aim of the present study is to clarify a potential association of IgE and asthma in absence of clinical allergy. To this purpose 1,219 consecutive patients of a pulmonary practice were evaluated. Nonallergic patients were defined by negative skin prick test, history of atopy and specific IgE, 509 subjects (42%) were nonallergic. Among these, 80 patients (16%) had elevated total IgE levels (>150 U x mL(-1)). Prevalence and severity of asthma in nonallergic subjects with IgE>150 U x mL(-1) were compared with subjects with normal IgE levels, and lung function parameters were correlated with serum IgE in all nonallergic subjects and asthmatics. Asthma was more prevalent in nonallergic subjects with elevated IgE levels than in nonallergic subjects with normal IgE (39% versus 14%; p<0.001). Lung function values of nonallergic asthmatics were lower for forced expiratory volume in one second (FEV1)% predicted (66+20% versus 83+/-17%; p<0.001), FEV1% forced vital capacity (FVC) (70+/-14% versus 81+/-8%; p<0.001) and forced mid expiratory flow (FEF25-75) (1.7+/-0.9 L x s(-1) versus 2.8+/-0.9 L x s(-1); p=0.002) in patients with high IgE compared to asthmatics with normal IgE, and were negatively correlated with log IgE levels in all nonallergic asthmatics. (FEVI % pred: r=-0.5, p<0.001; FEV1% FVC: r=-0.53, p<0.001; FEF25-75: r=-0.52, p<0.001). In the whole study population, multivariate analysis showed a greater than fivefold asthma risk for nonallergic individuals with serum IgE>150 U x mL(-1). These data support the role of IgE as risk factor for asthma independent of allergy, and they further challenge the definition of intrinsic asthma as "non-IgE mediated" entity.
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Cites
Lung volumes and forced ventilatory flows
Quanjer, P. H., Tammeling, G. J., Cotes, J. E., Pedersen, O. F., Peslin, R., & Yernault, J. (1993) · European Respiratory Journal · doi:10.1183/09041950.005s1693 · Cited by 5,484 · see citing works
(1993) · PubMed · Cited by 3,827 · see citing works
Standards for the Diagnosis and Care of Patients with Chronic Obstructive Pulmonary Disease
Celli, B. R., Snider, G. L., Heffner, J. E., Tiep, B. L., Ziment, I., Make, B. J., Braman, S. S., Olsen, G. N., & D, Y. Y. P. M. (1995) · Cited by 3,506 · see citing works
Lung Function Testing: Selection of Reference Values and Interpretative Strategies
(1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.5.1202 · Cited by 2,500 · see citing works
Association of Asthma with Serum IgE Levels and Skin-Test Reactivity to Allergens
Burrows, B., Martínez, F. D., Halonen, M. J., Barbee, R. A., & Cline, M. G. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200502 · Cited by 1,656 · see citing works
Lung Function Testing: Selectionof reference Values and Interpretative Strategies
Miller, A. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_1.1368b · Cited by 1,426 · see citing works
Postma, D. S., Bleecker, E. R., Amelung, P. J., Holroyd, K. J., Xu, J., Panhuysen, C. I. M., Meyers, D. A., & Levitt, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510053331402 · Cited by 757 · see citing works
Fahy, J. V., Fleming, H., Wong, H. H., Liu, J. T., Su, J. Q., Reimann, J. D., Fick, R. B., & Boushey, H. A. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.6.9196082 · Cited by 712 · see citing works
Ishizaka, K., Ishizaka, T., & Hornbrook, M. M. (1966) · PubMed · Cited by 511 · see citing works
Sutton, B. J., & Gould, H. J. (1993) · Nature · doi:10.1038/366421a0 · Cited by 507 · see citing works
Humbert, M. J. C., Durham, S. R., Ying, S., Kimmitt, P. T., Barkans, J. R., Assoufi, B., Pfister, R., Menz, G., Robinson, D. S., Kay, A. B., et al. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.5.8912771 · Cited by 405 · see citing works
A working classification of asthma
Rackemann, F. M. (1947) · The American Journal of Medicine · doi:10.1016/0002-9343(47)90204-0 · Cited by 254 · see citing works
Humbert, M. J. C., Grant, J. A., Taborda‐Barata, L., Durham, S. R., Pfister, R., Menz, G., Barkans, J. R., Ying, S., & Kay, A. B. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.6.8665058 · Cited by 219 · see citing works
Immunoglobulin levels in smokers and non-smokers.
GERRARD, J. W., Heiner, D. C., Ko, C., Mink, J., Meyers, A., & Dosman, J. A. (1980) · PubMed · Cited by 207 · see citing works
Physicochemical properties of reaginic antibody
Ishizaka, K., & Ishizaka, T. (1966) · Journal of Allergy · doi:10.1016/0021-8707(66)90091-8 · Cited by 192 · see citing works
Sunyer, J., Anto, J. M., Castellsagué, J., Soriano, J. B., & Roca, J. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09091880 · Cited by 181 · see citing works
Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy
van Herwerden, L., Harrap, S. B., Wong, Z. Y. H., Abramson, M. J., Kutin, J. J., Forbes, A. B., Raven, J. M., Lanigan, A., & Walters, E. H. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91863-9 · Cited by 164 · see citing works
Barbee, R. A., Halonen, M. J., Kaltenborn, W. T., Lebowitz, M. D., & Burrows, B. (1987) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(87)90241-7 · Cited by 158 · see citing works
The natural history of asthma in adults: The problem of irreversibility
Reed, C. E. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70221-6 · Cited by 155 · see citing works
Brown, W. G., Halonen, M. J., Kaltenborn, W. T., & Barbee, R. A. (1979) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(79)90127-1 · Cited by 126 · see citing works
Problems in defining normal limits for serum IgE
Klink, M. E., Cline, M. G., Halonen, M. J., et al. (1990) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(90)90153-u · Cited by 125 · see citing works
The Relationship Between Parental and Children's Serum IgE and Asthma
Burrows, B. A., Martínez, F. D., Cline, M. G., et al. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.5.7582283 · Cited by 98 · see citing works
The Interaction between Immunoglobulin E and Smoking in Airflow Obstruction in the Elderly
Dow, L., Coggon, D., Campbell, M. J., Osmond, C., & Holgate, S. T. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.2.402 · Cited by 67 · see citing works
Role of IgE in Hyperresponsiveness Induced by Passive Sensitization of Human Airways
Watson, N., Bodtke, K., Coleman, R., Dent, G., Morton, B. E., Rühlmann, E., MAGNUSSEN, H., & Rabe, K. F. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.3.9117014 · Cited by 59 · see citing works
Serum IgE levels in patients with inflammatory bowel disease.
Levo, Y., Shalit, M., Wollner, S., et al. (1986) · PubMed · Cited by 44 · see citing works
NON‐IgE‐MEDIATED ASTHMA IN CHILDREN
Østergaard, P. A. (1985) · Acta Paediatrica · doi:10.1111/j.1651-2227.1985.tb10019.x · Cited by 43 · see citing works
Immunoglobulins and hypersensitivity in human immunodeficiency virus (HIV) infection
Grieco, M. H. (1989) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(89)90170-x · Cited by 37 · see citing works
Is there a place for intrinsic asthma as a distinct immunopathological entity?
Kroegel, C., Jager, L., & Walker, C. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10030513 · Cited by 35 · see citing works
Atopy and immunoglobulin E concentrations in Hodgkin's disease and other lymphomas.
Amlot, P. L., & Green, L. A. (1978) · BMJ · doi:10.1136/bmj.1.6109.327 · Cited by 33 · see citing works
Mechanisms of Immune Sensitization of Human Bronchus
Rabe, K. F. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.supplement_2.13tac130 · Cited by 27 · see citing works
Influence of Environmental Factors on IgE Production
Takafuji, S., Suzuki, S., Muranaka, M., et al. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513866.ch12 · Cited by 26 · see citing works
[How to define the normal level of serum IgE in adults?].
Laurent, J., Noirot, C., Jc, A., et al. (1985) · PubMed · Cited by 20 · see citing works
Syndrome d'hyperimmunoglobulinémie E avec infections récurrentes (syndrome de Job)
Moneret‐Vautrin, D. A., Kanny, G., & Thinus, G. (1999) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(99)83030-6 · Cited by 5 · see citing works
[Studies on normal range of serum IgE concentration (author's transl)].
Haupt, I., Jung, H. J., Nuske, M., et al. (1979) · PubMed · Cited by 4 · see citing works
(1980) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(15)32518-7 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [6]6. Sunyer J, Anto JM, Soriano JB, Roca J. Total serum IgE is associated with asthma independently of specific IgE levels. Eur Respir J 1996; 9: 1880±1884.
- [11]11. Casale TB, Bernstein IL, Busse WW, et al. Use of an anti- Ige humanized monoclonal antobody in ragweed-induced allergic rhinits. J Allergy Clin Immunol 1997; 100: 110± 121.
- [14]14. Haupt I, Jung HJ, Nuske M, Ringelmann R. Studies on normal range of serum IgE concentration. Immun Infetrt 1979; 7: 97±102.
- [19]19. Moneret-Vautrin DA, Kanny G, Thinus G. Hyper- globulinemia E syndrome with recurrent infections (Job's syndrome). Rev Med Interne 1999; 20: 133±140.
- [26]26. Working Group "Bronchial Provocation Tests" of the German Society of Pneumology. Guidelines for the appli- cation of bronchial provocation tests with pharmaco- logical stimuli. Pneumologie 1998; 52: 215±220.
Cited by
Sorted by citations
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729 · see citing works
Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision
Brożek, J. L., Bousquet, J., Baena-Cagnani, C. E., Bonini, S., Canonica, G. W., Casale, T. B., van Wijk, R. G., Ohta, K., Zuberbier, T., & Schünemann, H. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.047 · Cited by 1,813 · see citing works
Pathophysiology of allergic inflammation
Barnes, P. J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01020.x · Cited by 361 · see citing works
Gergen, P. J., Arbes, S. J., Calatroni, A., Mitchell, H. E., & Zeldin, D. C. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.06.011 · Cited by 201 · see citing works
Chlorinated Pool Attendance, Atopy, and the Risk of Asthma during Childhood
Bernard, A., Carbonnelle, S., de Burbure, C., Michel, O., & Nickmilder, M. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8461 · Cited by 201 · see citing works
Local IgE in non‐allergic rhinitis
Campo, P., Rondón, C., Gould, H. J., Barrionuevo, E., Gevaert, P., & Blanca, M. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12476 · Cited by 101 · see citing works
Asthma severity and atopy: how clear is the relationship?
Carroll, W. D. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2005.088278 · Cited by 88 · see citing works
Nonallergic rhinitis and lower airway disease
Rondón, C., Bogas, G., Barrionuevo, E., Blanca, M., Torres, M. J., & Campo, P. (2017) · Allergy · doi:10.1111/all.12988 · Cited by 74 · see citing works
Prosperi, M. C. F., Belgrave, D., Buchan, I., Simpson, A., & Custovic, A. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12139 · Cited by 60 · see citing works
Management of asthma with anti-immunoglobulin E: A review of clinical trials of omalizumab
Nowak, D. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2005.10.004 · Cited by 59 · see citing works
The complexities of defining atopy in severe childhood asthma
Frith, J., Fleming, L., Bossley, C., Ullmann, N., & Bush, A. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03729.x · Cited by 46 · see citing works
Total serum immunoglobulin E as a marker for missed antigens on in vitro allergy screening
Hatcher, J. L., Cohen, S. D., & Mims, J. W. (2013) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21207 · Cited by 10 · see citing works
- Authors
- Beeh, K. M., Ksoll, M., & Buhl, R.
- Affiliations
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- ORCID
- Buhl, R
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2000-10
- Volume
- 16
- Issue
- 4
- Pages
- 609
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2137666424
- Cited by
- 154
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 2 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 10 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 13
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- serum total immunoglobulin E, asthma, non-allergic asthma, atopy, asthma risk, lung function, forced expiratory volume, airway hyperresponsiveness, asthma prevalence, asthma severity, skin prick test, specific IgE, FEV1/FVC ratio, FEF25-75
- MeSH terms
- Adult, Allergens, Asthma, Female, Humans, Immunoglobulin E, Male, Radioallergosorbent Test, Regression Analysis, Respiratory Function Tests, Retrospective Studies, Risk Factors, Skin Tests, Statistics, Nonparametric
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