Management of asthma with anti-immunoglobulin E: A review of clinical trials of omalizumab
Open accessAbstract
Immunoglobulin E (IgE) is a key mediator of the inflammatory reactions that are central to the pathogenesis of allergic diseases such as asthma and rhinitis. The recognition of the importance of IgE in allergic disease led to the development of omalizumab, a humanized monoclonal anti-IgE antibody that binds free circulating IgE and prevents the interaction between IgE and high-affinity (FcepsilonRI) and low-affinity (FcepsilonRII) IgE receptors on inflammatory cells. By removing free IgE, omalizumab also markedly downregulates the expression of high-affinity receptors on basophils, mast cells and dendritic cells. Several studies have shown that omalizumab effectively reduces the risk of exacerbations and hospitalization and improves symptom control, lung function and quality of life in patients with severe persistent allergic asthma. Importantly, omalizumab has been shown to be effective in patients with poorly controlled severe persistent allergic asthma, a group of patients with few effective additional treatment options. In addition, omalizumab has been shown to provide effective relief from the symptoms of allergic rhinitis (including patients with concomitant asthma). Patients with uncontrolled severe persistent allergic asthma are a challenging and difficult-to-treat population for whom omalizumab might represent an important new treatment option. In addition, omalizumab may provide a means to address comorbid allergic disease in patients with asthma. Further investigation is also warranted to explore potential applications of omalizumab in occupational asthma.
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Omalizumab has separately demonstrated effectiveness for asthma and for allergic rhinitis.
“Omalizumab has demonstrated effectiveness separately for asthma as well as AR.”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1815]
Omalizumab is an anti-IgE monoclonal antibody that binds free IgE, blocks its interaction with high-affinity IgE receptors, and down-regulates those receptors on inflammatory cells.
“Omalizumab is an anti-IgE mAb that binds free IgE, preventing interactions with high-affinity IgE receptors and resulting in receptor down-regulation on inflammatory cells.”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [1815]
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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
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- Authors
- Nowak, D.
- Affiliations
- LMU Klinikum (DE)
- Corresponding author
- Nowak, Dennis
- ORCID
- Nowak, Dennis
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 100
- Issue
- 11
- Pages
- 1907-1917
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2145024300
- Cited by
- 59
- References
- 72
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- omalizumab, anti-IgE therapy, allergic rhinitis, asthma exacerbations, hospitalization, lung function, quality of life, occupational asthma, comorbid allergic diseases
- MeSH terms
- Omalizumab, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal, Asthma, Clinical Trials as Topic, Drug Tolerance, Humans, Immunoglobulin E, Immunologic Factors, Occupational Diseases, Quality of Life, Rhinitis, Treatment Outcome, Anti-Asthmatic Agents, Antibodies, Monoclonal, Humanized
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