The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Evidence for enzyme complexes in the phenylpropanoid and flavonoid pathways
Abstract
A growing body of evidence indicates that phenylpropanoid and flavonoid metabolism is catalyzed, not by free‐floating ‘soluble’ enzymes, but via one or more membrane‐associated multienzyme complexes. This type of macromolecular organization has important implications for the overall efficiency, specificity, and regulation of these pathways. Classical biochemical studies of phenylpropanoid and flavonoid metabolism have laid a solid foundation for this model, providing evidence of the channeling of intermediates between enzyme active sites and co‐localization of enzymes in cell membranes. This work is now being extended using transgenic plants to determine how the partitioning of metabolites within these pathways is controlled, as well as applying sensitive methods to define specific interactions among the individual enzymes. Information from these studies promises to provide new insights into the structuring of biosynthetic pathways within cells, which should lead to more effective means for engineering the production of plant metabolites with nutritional and agronomic importance.
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Cites
Physiology and Molecular Biology of Phenylpropanoid Metabolism
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Genetics and Biochemistry of Anthocyanin Biosynthesis.
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How genes paint flowers and seeds
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Genetics and Biochemistry of Anthocyanin Biosynthesis
Holton, T. A., & Cornish, E. C. (1995) · The Plant Cell · doi:10.2307/3870058 · Cited by 802
The flavonoid biosynthetic pathway in plants: Function and evolution
Koes, R. E., Quattrocchio, F., & Mol, J. N. M. (1994) · BioEssays · doi:10.1002/bies.950160209 · Cited by 768
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Cited by
THE GENETICS AND BIOCHEMISTRY OF FLORAL PIGMENTS
Grotewold, E. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105248 · Cited by 1,587
Significance of flavonoids in plant resistance: a review
Treutter, D. (2006) · Environmental Chemistry Letters · doi:10.1007/s10311-006-0068-8 · Cited by 1,253
Proanthocyanidins – a final frontier in flavonoid research?
Dixon, R. A., Xie, D., & Sharma, S. B. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2004.01217.x · Cited by 1,160
Metabolon formation and metabolic channeling in the biosynthesis of plant natural products
Jørgensen, K., Rasmussen, A. V., Morant, M., Nielsen, A. H., Bjarnholt, N., Zagrobelny, M., Bak, S., & Møller, B. L. (2005) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2005.03.014 · Cited by 537
Walton, N. J., Mayer, M. J., & Narbad, A. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00149-3 · Cited by 530
Metadata
- Authors
- Winkel‐Shirley, B.
- Venue
- Physiologia Plantarum
- Publisher
- Wiley
- Published
- 1999-09
- Volume
- 107
- Issue
- 1
- Pages
- 142-149
- ISSN
- 0031-9317 (ISSN-L)
- 1399-3054
- OpenAlex
- W2082765353
- Cited by
- 296
- References
- 39
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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