Cited by 148Antifungal resistance and susceptibilityPharmacovigilance and Adverse Drug ReactionsFungal Infections and Studies

Safety and tolerability of caspofungin acetate in the treatment of fungal infections

Sable, C.A., Nguyen, B‐Y T., Chodakewitz, J.A., DiNubile, M.J.·2002·Transplant Infectious Disease

Abstract

Caspofungin acetate is the first member of the novel echinocandin class of antifungal drugs to be marketed in the United States. It has recently been approved for use in patients with invasive aspergillosis who are refractory to or intolerant of conventional therapy. Accordingly, its safety profile is particularly important to review. The safety and tolerability of caspofungin have been examined in 623 persons, including 295 patients who received >/= 50 mg/day for at least one week in clinical studies. In the 263 patients, given caspofungin in randomized double-blind active-control trials to date, there have been no serious clinical or laboratory drug-related adverse events; caspofungin was discontinued in only 2% of these patients because of drug-related adverse experiences. Caspofungin may have potentially important drug interactions with cyclosporine and tacrolimus.

Integrity signals

Registry

Crossref · 10.1034/j.1399-3062.2002.01004.x

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Caspofungin has been shown to be as effective as both amphotericin B deoxycholate and fluconazole when used as therapy for oropharyngeal and esophageal candidiasis.

    “Caspofungin has been shown to be as effective as both amphotericin B deoxycholate and fluconazole when used as therapy for oropharyngeal and esophageal candidiasis [57][58][59][60].”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [57]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sable, C. A., Nguyen, B. T., Chodakewitz, J. A., & DiNubile, M. J.
Affiliations
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Venue
Transplant Infectious Disease
Publisher
Wiley
Published
2002-03
Volume
4
Issue
1
Pages
25-30
ISSN
  • 1398-2273 (ISSN-L)
  • 1399-3062
OpenAlex
W2041457471
Cited by
148
References
5
Citations by year
2025: 4 · 2024: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 7
FWCI
12.32
Type
journal article
Language
en
Open access
closed
Locations
  • Transplant Infectious Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
caspofungin acetate, echinocandins, antifungal agents, invasive aspergillosis, drug safety, tolerability, adverse drug reactions, refractory fungal infection
MeSH terms
Caspofungin, Anti-Bacterial Agents, Antifungal Agents, Aspergillosis, Candidiasis, Double-Blind Method, Drug Tolerance, Fever, Headache, Humans, Mycoses, Peptides, Peptides, Cyclic, Phlebitis, Retrospective Studies, Randomized Controlled Trials as Topic, Immunocompromised Host, Drug Approval, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Echinocandins, Lipopeptides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review