Echinocandins for management of invasive candidiasis in patients with liver disease and liver transplantation

Yeoh, Siang Fei; Lee, Tae Jin; Chew, Ka Lip; Lin, Stephen; Yeo, Dennis; Setia, Sajita

doi:10.2147/idr.s165676

Cited by 20Antifungal resistance and susceptibilityFungal Infections and StudiesLiver Disease and Transplantation

Echinocandins for management of invasive candidiasis in patients with liver disease and liver transplantation

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Yeoh, Siang Fei, Lee, Tae Jin, Chew, Ka Lip, Lin, Stephen, Yeo, Dennis, Setia, Sajita·2018·Infection and Drug Resistance

DOI 10.2147/idr.s165676PMC PMC5985852

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Abstract

species remains one of the most important causes of opportunistic infections worldwide. Invasive candidiasis (IC) is associated with considerable morbidity and mortality in liver disease (LD) patients if not treated promptly. Echinocandins are often recommended as a first-line empirical treatment for managing IC and can especially play a critical role in managing IC in LD patients. However, advanced LD patients are often immunocompromised and critically ill. Hence altered pharmacokinetics, drug interactions as well as tolerance issues of antifungal treatments are a concern in these patients. This comprehensive review examines the epidemiology, risk factors and diagnosis of IC in patients with LD and evaluates differences between three available echinocandins for treating this group of patients.

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Echinocandins differ based on route of metabolism, half-life, and safety.
“They differ based on the route of metabolism, half-life, and safety [102].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [102]
Frequent prescription and usage of echinocandins result in resistance development by decreasing the targeted Candida species susceptibility.
“The frequent prescription and usage of echinocandins result in resistance development by decreasing the targeted Candida species susceptibility [102].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [102]
Echinocandins exist according to international guidelines in three available types: caspofungin, anidulafungin, and micafungin.
“Echinocandins exist according to the international guidelines in three available types (caspofungin, anidulafungin, and micafungin).”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [102]

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Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
Hassan, Y., Chew, S. Y., & Than, L. T. L. (2021) · Journal of Fungi · doi:10.3390/jof7080667 · Cited by 170 · see citing works
Treatment practices for adults with candidemia at 9 active surveillance sites—United States, 2017–2018.
Gold, J. A. W., Seagle, E. E., Nadle, J., Barter, D. M., Czaja, C. A., Johnston, H., Farley, M. M., Thomas, S., Harrison, L. H., Fischer, J., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab512 · Cited by 20 · see citing works

Authors: Yeoh, S. F., Lee, T. J., Chew, K. L., Lin, S., Yeo, D., & Setia, S.
Affiliations: National University Health System (SG)
National University of Singapore (SG)
National University Hospital (SG)
Pfizer (China) (CN)
Corresponding author: Setia, Sajita
ORCID: Yeoh, Siang Fei
Chew, Ka Lip
Lin, Stephen
Setia, Sajita
Venue: Infection and Drug Resistance
Publisher: Informa UK Limited
Published: 2018-05
Volume: Volume 11
Pages: 805-819
ISSN: 1178-6973 (ISSN-L)
DOI: 10.2147/idr.s165676
PMC: PMC5985852
OpenAlex: W2806463970
Cited by: 20
References: 173
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1
FWCI: 0.48
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (unspecified)
Locations: Infection and Drug Resistance (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders: Pfizer
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords: echinocandins, invasive candidiasis, liver disease, liver transplantation, antifungal therapy, pharmacokinetics, drug interactions, immunocompromised patients, Candida species, risk factors, diagnosis

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Echinocandins for management of invasive candidiasis in patients with liver disease and liver transplantation

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