The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Stress and depression: possible links to neuron death in the hippocampus
Abstract
Recent intriguing reports have shown an association between major depression and selective and persistent loss of hippocampal volume, prompting considerable speculation as to its underlying causes. In this paper we focus on the hypothesis that overt hippocampal neuron death could cause this loss and review current knowledge about how hippocampal neurons die during insults. We discuss (a) the trafficking of glutamate and calcium during insults; (b) oxygen radical generation and programmed cell death occurring during insults; (c) neuronal defenses against insults; (d) the role of energy availability in modulating the extent of neuron loss following such insults. The subtypes of depression associated with hippocampal atrophy typically involve significant hypersecretion of glucocorticoids, the adrenal steroids secreted during stress. These steroids have a variety of adverse affects, direct and indirect, in the hippocampus. Thus glucocorticoids may play a contributing role toward neuron death. We further discuss how glucocorticoids cause or exacerbate cellular changes associated with hippocampal neuron loss in the context of the events listed above.
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Hippocampal Volume Reduction in Major Depression
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Self-citationHippocampal damage associated with prolonged and fatal stress in primates
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Cited by
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
Hippocampal volume and depression: a meta-analysis of MRI studies
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The stress system in the human brain in depression and neurodegeneration
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The bright side of being blue: depression as an adaptation for analyzing complex problems.
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Metadata
- Authors
- Lee, A. L., Ogle, W. O., & Sapolsky, R. M.
- Venue
- Bipolar Disorders
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 4
- Issue
- 2
- Pages
- 117-128
- ISSN
- 1398-5647 (ISSN-L)
- 1399-5618
- OpenAlex
- W2098383991
- Cited by
- 465
- References
- 19
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, A. L., Ogle, W. O., & Sapolsky, R. M. (2002). Stress and depression: possible links to neuron death in the hippocampus. Bipolar Disorders. https://doi.org/10.1034/j.1399-5618.2002.01144.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
