Acquisition and loss of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia over a 5‐year period: effect of a triclosan/copolymer dentifrice
Abstract
Objectives The present study describes the natural history of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia over a 5-year period and the effect of a triclosan/copolymer dentifrice on these organisms in a normal adult population. Material and methods Subgingival plaque samples were collected from 504 adult volunteers. Probing pocket depths (PPD) and relative attachment levels were measured using an automated probe. Participants were matched for disease status (CPI), plaque index, age and gender, and allocated to receive either a triclosan/copolymer or placebo dentifrice. Re-examination and subgingival plaque sampling was repeated after 1, 2, 3, 4 and 5 years. P. gingivalis, A. actinomycetemcomitans and P. intermedia were detected and quantitated using an enzyme linked immunosorbent assay. Logistic regression and generalised linear modelling were used to analyse the data. Results This 5-year longitudinal study showed considerable volatility in acquisition and loss (below the level of detection) of all three organisms in this population. Relatively few subjects had these organisms on multiple occasions. While P. gingivalis was related to loss of attachment and to PPD >/=3.5 mm, there was no relationship between A. actinomycetemcomitans or P. intermedia and disease progression over the 5 years of the study. Smokers with P. gingivalis had more PPD >/=3.5 mm than smokers without this organism. There was no significant effect of the triclos…
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Periodontal disease has a complex multifactorial etiology including host immune response and environmental factors, likely involving multiple cell types.
“Overall, a complex multifactorial etiology of periodontal disease including the host immune response and environmental factors has been suggested likely involving multiple cell types [78].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [78]
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Brown, B. N., Ratner, B. D., Goodman, S. B., Amar, S., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.034 · Cited by 926 · see citing works
“etiology of periodontal disease including the host immune response and environmental factors has been suggested likely involving multiple cell types [78].”
BackgroundZelkha, S. A., Freilich, R. W., & Amar, S. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00358.x · Cited by 81 · see citing works
Chapter 13: Diet and periodontal diseases
Woelber, J. P., & Tennert, C. (2020) · Monographs in Oral Science · doi:10.1159/000455380 · Cited by 54 · see citing works
Bogren, A., Teles, R. P., Torresyap, G., Haffajee, A. D., Socransky, S. S., Jönsson, K., & Wennström, J. L. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01180.x · Cited by 22 · see citing works
- Authors
- Cullinan, M. P., Hamlet, S. M., Westerman, B., Palmer, J. E., Faddy, M. J., & Seymour, G. J.
- Affiliations
- The University of Queensland (AU)
- University of Birmingham (GB)
- Corresponding author
- Cullinan, M. P.
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2003-06
- Volume
- 30
- Issue
- 6
- Pages
- 532-541
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W2096358043
- Cited by
- 61
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2021: 5 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal Of Clinical Periodontology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Colgate-Palmolive Company
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, subgingival plaque, periodontal disease, attachment loss, probing depth, smoking, oral bacteria, natural history of infection, plaque control, periodontitis
- MeSH terms
- Adolescent, Adult, Aged, Anti-Infective Agents, Local, Cross-Sectional Studies, Dental Plaque, Dentifrices, Female, Humans, Longitudinal Studies, Male, Maleates, Middle Aged, Periodontal Index, Polyethylenes, Triclosan, Colony Count, Microbial, Linear Models, Logistic Models, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia
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