Cited by 1,200Dermatology and Skin DiseasesReliability and Agreement in MeasurementContact Dermatitis and Allergies

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The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis

Hanifin, J. M., Thurston, M., Omoto, M., Cherill, R., Tofte, S. J., Graeber, M., Evaluator Group, The Easi·2001·Experimental Dermatology

DOI 10.1034/j.1600-0625.2001.100102.x

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Abstract

OBJECTIVE: To test the reliability of the eczema area and severity index (EASI) scoring system by assessing inter- and intra-observer consistency. DESIGN: Training of evaluators, application, and assessment over 2 consecutive days. SETTING: An academic center. PATIENTS: Twenty adults and children with atopic dermatitis (AD); cohort 1 (10 patients > or = 8 years) and cohort 2 (10 patients < 8 years). INTERVENTIONS: None. MAIN OUTCOME MEASURE: The EASI was used by 15 dermatologist evaluators to assess atopic dermatitis in cohort 1 and cohort 2 on 2 consecutive days. Inter- and intraobserver reliability were analyzed. RESULTS: Overall intra-evaluator reliability of the EASI was in the fair-to-good range. Inter-evaluator reliability analyses indicated that the evaluators assessed the patients consistently across both study days. CONCLUSIONS: This study demonstrated that the EASI can be learned quickly and utilized reliably in the assessment of severity and extent of AD. There was consistency among the evaluators between consecutive days of evaluation. These results support the use of the EASI in clinical trials of therapeutic agents for AD.

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Authors: Hanifin, J. M., Thurston, M., Omoto, M., Cherill, R., Tofte, S. J., Graeber, M., & Evaluator Group, T. E.
Affiliations: Oregon Health & Science University (US)
Novartis (Switzerland) (CH)
Shiga University of Medical Science (JP)
Corresponding author: Hanifin, J. M.
ORCID: Hanifin, J. M.
Venue: Experimental Dermatology
Publisher: Wiley
Published: 2001-02
Volume: 10
Issue: 1
Pages: 11-18
ISSN: 0906-6705 (ISSN-L)
1600-0625
DOI: 10.1034/j.1600-0625.2001.100102.x
OpenAlex: W2117359358
Cited by: 1,200
References: 17
Citations by year: 2026: 69 · 2025: 85 · 2024: 92 · 2023: 101 · 2022: 84 · 2021: 98 · 2020: 82 · 2019: 63 · 2018: 47 · 2017: 46 · 2016: 53 · 2015: 28 · 2014: 43 · 2013: 23 · 2012: 21
FWCI: 20.78
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2713 d)
Locations: Experimental Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: Eczema Area and Severity Index, atopic dermatitis, inter-rater reliability, intra-rater reliability, disease severity assessment, disease extent assessment, clinical trial outcome measures
MeSH terms: Adolescent, Adult, Child, Child, Preschool, Dermatitis, Atopic, Dermatology, Eczema, Humans, Infant, Infant, Newborn, Severity of Illness Index, Reproducibility of Results, Cohort Studies, Observer Variation

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The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis

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