The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches
Abstract
Summary: The nuclear hormone receptor retinoic acid‐related orphan receptor (ROR)γt is required for the development of lymph nodes (LNs) and Peyer's patches (PPs), as these organs are absent in RORγt‐deficient mice. During fetal life, RORγt is expressed exclusively in lymphoid tissue‐inducer (LTi) cells, a cell type that localizes in developing LNs and PPs. LTi cells express surface lymphotoxin α1β2 that activates specialized mesenchymal cells to produce chemokines, upregulate adhesion molecules and induce further maturation of lymphoid organs. RORγt inhibits nuclear factor of activated T‐cell (NFAT) function in cell lines and induces the expression of Bcl‐xL and p27 kip1 in the adult thymus, suggesting that RORγt prevents cell activation, cell‐cycle progression, and apoptosis. We propose that RORγt, together with the inhibitor of basic helix‐loop‐helix transcription factor Id2, ensures generation and survival of fetal LTi cells necessary for the development of LNs and PPs.
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The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes
Jetten, A. M., Kurebayashi, S., & Ueda, E. (2001) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(01)69048-2 · Cited by 232
Cited by
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Self-citationTH17 cells in development: an updated view of their molecular identity and genetic programming
Dong, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2295 · Cited by 1,064
Eberl, G., Marmon, S., Sunshine, M.-J., Rennert, P. D., Choi, Y., & Littman, D. R. (2004) · Nature Immunology · doi:10.1038/ni1022 · Cited by 985
Self-citationInterleukin-22: Immunobiology and Pathology
Dudakov, J. A., Hanash, A. M., & van den Brink, M. R. M. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112123 · Cited by 905
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
Cyster, J. G. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115628 · Cited by 856
Metadata
- Authors
- Eberl, G., & Littman, D. R.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2003-09-10
- Volume
- 195
- Issue
- 1
- Pages
- 81-90
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1786547448
- Cited by
- 192
- References
- 3
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
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