The effects of day‐time exogenous melatonin administration on cardiac autonomic activity
Abstract
Melatonin has a functional role in the nocturnal regulation of sleep and thermoregulation. In addition to its action on peripheral receptors, melatonin may act by altering autonomic activity. To determine the effect of melatonin on cardiac autonomic activity, 5 mg of melatonin or placebo was orally administered to 12 young subjects at 14:00 hr, in a repeated measures design. Melatonin decreased sleep onset latency to Stage 2 sleep by 4.92+/-1.81 min (measured by Multiple Sleep Latency Tests), rectal temperature by 0.19+/-0.05 degrees C, and increased foot temperature by 0.74+/-0.45 degrees C (all P 0.05). As the decrease in pre-ejection period is likely to have resulted from a decrease in blood pressure, these results do not confirm an effect of melatonin on cardiac sympathetic activity. However, the results do clearly indicate that melatonin is unlikely to drive the previously observed presleep increase in cardiac parasympathetic activity.
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The data from the present study do not provide support for the concept that melatonin increases cardiac vagal tone in humans.
“Thus, the data from the present study do not provide support for this concept in humans, and are in agreement with earlier studies employing spectral analysis of respiratory sinus arrhythmias (Burgess et al. 2001; Harris et al. 2001).”
From Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans (2003) · cites this paper as Harris et al. 2001
The data from the present study are in agreement with earlier studies employing spectral analysis of respiratory sinus arrhythmias.
“Thus, the data from the present study do not provide support for this concept in humans, and are in agreement with earlier studies employing spectral analysis of respiratory sinus arrhythmias (Burgess et al. 2001; Harris et al. 2001).”
From Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans (2003) · cites this paper as Harris et al. 2001
Cites
Sympathetic-Nerve Activity during Sleep in Normal Subjects
Somers, V. K., Dyken, M. E., Mark, A. L., & Abboud, F. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280502 · Cited by 1,574 · see citing works
Warm feet promote the rapid onset of sleep
Kräuchi, K., Cajochen, C., Werth, E., & Wirz-Justice, A. (1999) · Nature · doi:10.1038/43366 · Cited by 398 · see citing works
Sleep and circadian influences on cardiac autonomic nervous system activity
Burgess, H. J., Trinder, J., Kim, Y., & Luke, D. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1761 · Cited by 279 · see citing works
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Burgess, H. J., Sletten, T., Savic, N., Gilbert, S. S., & Dawson, D. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1214 · Cited by 94 · see citing works
Self-citationMelatonin attenuates the sympathetic nerve responses to orthostatic stress in humans
Ray, C. A. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.01043.x · Cited by 51 · see citing works
- Authors
- Harris, A. S., Burgess, H. J., & Dawson, D.
- Affiliations
- University of South Australia (AU)
- Corresponding author
- Burgess, Helen J.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2001-10
- Volume
- 31
- Issue
- 3
- Pages
- 199-205
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2167215225
- Cited by
- 29
- References
- 3
- Citations by year
- 2023: 3 · 2021: 1 · 2020: 1 · 2014: 4 · 2013: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- University of South Australia
- Australian Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- melatonin, cardiac autonomic activity, heart rate, pre-ejection period, cardiac sympathetic activity, cardiac parasympathetic activity, respiratory sinus arrhythmia, sleep latency, thermoregulation, rectal temperature, foot temperature, circadian rhythm
- MeSH terms
- Administration, Oral, Adult, Autonomic Nervous System, Body Temperature, Drug Administration Schedule, Electrocardiography, Female, Heart, Heart Rate, Humans, Male, Melatonin, Saliva, Sleep Stages
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