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Endocytosis Via Caveolae

Open access
Pelkmans, Lucas, Helenius, Ari·2002·Traffic

Abstract

Caveolae are flask‐shaped invaginations present in the plasma membrane of many cell types. They have long been implicated in endocytosis, transcytosis, and cell signaling. Recent work has confirmed that caveolae are directly involved in the internalization of membrane components (glycosphingolipids and glycosylphosphatidylinositol‐anchored proteins), extracellular ligands (folic acid, albumin, autocrine motility factor), bacterial toxins (cholera toxin, tetanus toxin), and several nonenveloped viruses (Simian virus 40, Polyoma virus). Unlike clathrin‐mediated endocytosis, internalization through caveolae is a triggered event that involves complex signaling. The mechanism of internalization and the subsequent intracellular pathways that the internalized substances take are starting to emerge.

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Metadata

Authors
Pelkmans, L., & Helenius, A.
Venue
Traffic
Publisher
Wiley
Published
2002-05
Volume
3
Issue
5
Pages
311-320
ISSN
  • 1398-9219 (ISSN-L)
  • 1600-0854
OpenAlex
W2015752928
Cited by
747
References
0
FWCI
14.28
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Endocytosis Via Caveolae. https://app.cochat.ai/papers/10.1034/j.1600-0854.2002.30501.x
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Pelkmans, L., & Helenius, A. (2002). Endocytosis Via Caveolae. Traffic. https://doi.org/10.1034/j.1600-0854.2002.30501.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.