Cited by 460interferon and immune responsesVirology and Viral DiseasesCellular transport and secretion

Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity

Haller, Otto, Kochs, Georg·2002·Traffic

Abstract

Mx proteins are interferon‐induced GTPases that belong to the dynamin superfamily of large GTPases. Similarities include a high molecular weight, a propensity to self‐assemble, a relatively low affinity for GTP, and a high intrinsic rate of GTP hydrolysis. A unique property of Mx GTPases is their antiviral activity against a wide range of RNA viruses, including bunya‐ and orthomyxoviruses. The human MxA GTPase accumulates in the cytoplasm of interferon‐treated cells, partly associating with the endoplasmic reticulum. In the case of bunyaviruses, MxA interferes with transport of the viral nucleocapsid protein (N) to the Golgi compartment, the site of virus assembly. In the case of Thogoto virus (an orthomyxovirus), MxA prevents the incoming viral nucleocapsids from being transported into the nucleus, the site of viral transcription and replication. In both cases, the GTP‐binding and carboxy‐terminal effector functions of MxA are required for target recognition. In general, Mx GTPases appear to detect viral infection by sensing nucleocapsid‐like structures. As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles.

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Crossref · 10.1034/j.1600-0854.2002.31003.x

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  • Increased expression of MUC5AC mRNA in bronchial epithelial cells has been reported for mice after RSV infection.

    “Increased expression of MUC5AC mRNA in bronchial epithelial cells has been reported for mice after RSV infection (97)”

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Authors
Haller, O., & Kochs, G.
Affiliations
University of Freiburg (DE)
Corresponding author
Haller, Otto
Venue
Traffic
Publisher
Wiley
Published
2002-09-16
Volume
3
Issue
10
Pages
710-717
ISSN
  • 1398-9219 (ISSN-L)
  • 1600-0854
OpenAlex
W2090023448
Cited by
460
References
53
Citations by year
2026: 2 · 2025: 10 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 9 · 2020: 15 · 2019: 8 · 2018: 11 · 2017: 14 · 2016: 8 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 23
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Locations
  • Traffic (publishedVersion)
  • PubMed (publishedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
Mx protein, MxA, dynamin superfamily, antiviral activity, Bunyaviridae, orthomyxoviruses, Thogoto virus, Golgi apparatus, endoplasmic reticulum, GTP hydrolysis, viral assembly, RNA viruses, host-virus interaction
MeSH terms
Antiviral Agents, Interferons, Molecular Weight, Subcellular Fractions, GTP-Binding Proteins, GTP Phosphohydrolases, Dynamins, Myxovirus Resistance Proteins

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