Cited by 460interferon and immune responsesVirology and Viral DiseasesCellular transport and secretion

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity

Haller, Otto, Kochs, Georg·2002·Traffic

DOI 10.1034/j.1600-0854.2002.31003.x

Open this paper in CoChat — free account

Abstract

Mx proteins are interferon‐induced GTPases that belong to the dynamin superfamily of large GTPases. Similarities include a high molecular weight, a propensity to self‐assemble, a relatively low affinity for GTP, and a high intrinsic rate of GTP hydrolysis. A unique property of Mx GTPases is their antiviral activity against a wide range of RNA viruses, including bunya‐ and orthomyxoviruses. The human MxA GTPase accumulates in the cytoplasm of interferon‐treated cells, partly associating with the endoplasmic reticulum. In the case of bunyaviruses, MxA interferes with transport of the viral nucleocapsid protein (N) to the Golgi compartment, the site of virus assembly. In the case of Thogoto virus (an orthomyxovirus), MxA prevents the incoming viral nucleocapsids from being transported into the nucleus, the site of viral transcription and replication. In both cases, the GTP‐binding and carboxy‐terminal effector functions of MxA are required for target recognition. In general, Mx GTPases appear to detect viral infection by sensing nucleocapsid‐like structures. As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles.

Integrity signals

Registry

Crossref · 10.1034/j.1600-0854.2002.31003.x

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding
Hinshaw, J. E., & Schmid, S. L. (1995) · Nature · doi:10.1038/374190a0 · Cited by 824
Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation
Sweitzer, S. M., & Hinshaw, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81207-6 · Cited by 682
Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus
Staeheli, P., Haller, O., Boll, W., Lindenmann, J.-M., & Weissmann, C. (1986) · Cell · doi:10.1016/0092-8674(86)90493-9 · Cited by 488
Self-citation
Dynamin and its partners: a progress report
Schmid, S. L., McNiven, M. A., & Camilli, P. V. D. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80066-5 · Cited by 399
Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring
Stowell, M. H. B., Marks, B., Wigge, P., & McMahon, H. T. (1999) · Nature Cell Biology · doi:10.1038/8997 · Cited by 378
Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis
Sever, S., Muhlberg, A. B., & Schmid, S. L. (1999) · Nature · doi:10.1038/19024 · Cited by 367
Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins
Obar, R. A., Collins, C. A., Hammarback, J. A., Shpetner, H. S., & Vallee, R. B. (1990) · Nature · doi:10.1038/347256a0 · Cited by 349
The dynamin family of mechanoenzymes: pinching in new places
McNiven, M. A., Cao, H., Pitts, K. R., & Yoon, Y. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01538-8 · Cited by 343
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins
Prakash, B., Praefcke, G. J. K., Renault, L., Wittinghofer, A., & Herrmann, C. (2000) · Nature · doi:10.1038/35000617 · Cited by 323
Mx proteins: mediators of innate resistance to RNA viruses
Haller, O., Frese, M., & Kochs, G. (1998) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.17.1.1084 · Cited by 286
Self-citation

Show all 53 references

Sorted by citations

Items 201–300 of 460

The Cotton Rat as a Model to Study Influenza Pathogenesis and Immunity
Eichelberger, M. C. (2007) · Viral Immunology · doi:10.1089/vim.2007.0017 · Cited by 40
Receptor Characterization and Susceptibility of Cotton Rats to Avian and 2009 Pandemic Influenza Virus Strains
Blanco, J. C. G., Pletneva, L. M., Wan, H., Araya, Y., Angel, M., Oue, R. O., Sutton, T. C., & Perez, D. R. (2012) · Journal of Virology · doi:10.1128/jvi.00638-12 · Cited by 40
Nuclear Import in Viral Infections
Greber, U. F., & Fornerod, M. W. J. (2005) · Springer eBooks · doi:10.1007/3-540-26764-6_4 · Cited by 40
The Myxovirus‐Resistance Protein, MX 1, is a Component of Exosomes Secreted by Uterine Epithelial Cells
Racicot, K. E., Schmitt, A. P., & OTT, T. L. (2012) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2012.01109.x · Cited by 41
Human Antiviral Protein MxA Forms Novel Metastable Membraneless Cytoplasmic Condensates Exhibiting Rapid Reversible Tonicity-Driven Phase Transitions
Davis, D., Yuan, H., Liang, F., Yang, Y., Westley, J., Petzold, C., Dancel-Manning, K., Deng, Y., Sall, J., & Sehgal, P. B. (2019) · Journal of Virology · doi:10.1128/jvi.01014-19 · Cited by 40
Robust Innate Immunity of Young Rabbits Mediates Resistance to Rabbit Hemorrhagic Disease Caused by Lagovirus Europaeus GI.1 But Not GI.2
Neave, M. J., Hall, R. N., Huang, N., McColl, K. A., Kerr, P. J., Hoehn, M., Taylor, J. M., & Strive, T. (2018) · Viruses · doi:10.3390/v10090512 · Cited by 39
Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C)
Ghosh, M., Schaefer, T. M., Fahey, J. V., Wright, J. A., & Wira, C. R. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.05.023 · Cited by 37
Evidence for a role of type I interferons in the pathogenesis of dermatomyositis
Wenzel, J., Scheler, M., Bieber, T. R. M., & Tüting, T. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06786.x · Cited by 37
HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming
Meng, X., Zhu, Y., Yang, W., Zhang, J., Jin, W., Tian, R., Yang, Z., & Wang, R. (2023) · Virologica Sinica · doi:10.1016/j.virs.2023.11.010 · Cited by 36
Three Mx genes with differential response to VNNV infection have been identified in Gilthead seabream (Sparus aurata)
Fernández-Trujillo, M. A., Novel, P., Manchado, M., Sepulcre, M. P., Mulero, V., Borrego, J. J., Álvarez, M. C., & Béjar, J. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.03.008 · Cited by 36
CXCR3 <-> ligand–mediated skin inflammation in cutaneous lichenoid graft-versus-host disease
Wenzel, J., Lucas, S., Zahn, S., Mikus, S., Metze, D., Ständer, S., von Stebut, E., Hillen, U., Bieber, T. R. M., & Tüting, T. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.10.647 · Cited by 36
The Antiviral Potential of Interferon-Induced Cotton Rat Mx Proteins Against Orthomyxovirus (Influenza), Rhabdovirus, and Bunyavirus
Stertz, S., Dittmann, J., Blanco, J. C. G., Pletneva, L. M., Haller, O., & Kochs, G. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.0176 · Cited by 36
Self-citation
Differential regulation of TLR mediated innate immune response of mouse neuronal cells following infection with novel ECSA genotype of Chikungunya virus with and without E1:A226V mutation
Priya, R., Dhanwani, R., Patro, I. K., Rao, P. V., & Parida, M. M. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2013.09.030 · Cited by 35
Type I IFN Induction in Response to Listeria monocytogenes in Human Macrophages: Evidence for a Differential Activation of IFN Regulatory Factor 3 (IRF3)
Reimer, T., Schweizer, M., & Jungi, T. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1166 · Cited by 35
Positive diversifying selection in avian Mx genes
Berlin, S., Qu, L., Li, X., Yang, N., & Ellegren, H. (2008) · Immunogenetics · doi:10.1007/s00251-008-0324-0 · Cited by 35
Anti-Human Immunodeficiency Virus Activity of Tau Interferon in Human Macrophages: Involvement of Cellular Factors and β-Chemokines
Rogez, C., Martin, M. C., Dereuddre‐Bosquet, N., Martal, J., Dormont, D., & Clayette, P. (2003) · Journal of Virology · doi:10.1128/jvi.77.23.12914-12920.2003 · Cited by 34
Inhibition of Dugbe nairovirus replication by human MxA protein
Bridgen, A., Dalrymple, D. A., Weber, F., & Elliott, R. M. (2003) · Virus Research · doi:10.1016/j.virusres.2003.10.002 · Cited by 34
Immune modulatory effects of Aloe arborescens extract on the piscine SAF-1 cell line
Picchietti, S., Bernini, C., Belardinelli, M. C., Ovidi, E., Taddei, A., Guerra, L., Abelli, L., & Fausto, A. M. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.02.019 · Cited by 33
The extensive transgenerational transcriptomic effects of ocean acidification on the olfactory epithelium of a marine fish are associated with a better viral resistance
Cohen‐Rengifo, M., Danion, M., Gonzalez, A., Bégout, M., Cormier, A., Noël, C., Cabon, J., Vitré, T., Mark, F. C., & Mazurais, D. (2022) · BMC Genomics · doi:10.1186/s12864-022-08647-w · Cited by 33
Anti-HIV State but Not Apoptosis Depends on IFN Signature in CD4+ T Cells
Audigé, A., Urosevic, M., Schlaepfer, E., Walker, R., Powell, D., Hallenberger, S., Joller, H., Simon, H., Dummer, R., & Speck, R. F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6227 · Cited by 32
Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein
Bradley, R. R., & Terajima, M. (2005) · Virus Research · doi:10.1016/j.virusres.2005.06.003 · Cited by 33
Porcine Mx1 Protein Inhibits Classical Swine Fever Virus Replication by Targeting Nonstructural Protein NS5B
Zhou, J., Chen, J., Zhang, X.-M., Gao, Z.-C., Liu, C., Zhang, Y., Hou, J., Li, Z.-Y., Kan, L., Li, W., et al. (2018) · Journal of Virology · doi:10.1128/jvi.02147-17 · Cited by 32
Upregulation of a Small Subset of Genes Drives Type I Interferon-Induced Antiviral Memory
Jaitin, D. A., & Schreiber, G. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.0162 · Cited by 32
Chapter 13 Visualization of Dynamins
Mears, J. A., & Hinshaw, J. E. (2008) · Methods in cell biology · doi:10.1016/s0091-679x(08)00413-5 · Cited by 32
The ins and outs in membrane dynamics: tubulation and vesiculation
VERMA, D., & Hong, Z. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.02.004 · Cited by 31
Inhibition of vesicular stomatitis virus infection in epithelial cells by alpha interferon-induced soluble secreted proteins
Basu, M., Maitra, R. K., Xiang, Y., Meng, X., Banerjee, A. K., & Bose, S. (2006) · Journal of General Virology · doi:10.1099/vir.0.82039-0 · Cited by 31
Low frequency of the Mx allele for viral resistance predates recent intensive selection in domestic chickens
Balkissoon, D., Staines, K. A., McCauley, J. W., Wood, J. L. N., Young, J. R., Kaufman, J., & Butter, C. (2007) · Immunogenetics · doi:10.1007/s00251-007-0235-5 · Cited by 31
IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3
Kaiser, F., Kaufmann, S. H. E., & Zerrahn, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01039 · Cited by 30
Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
Kim, K., Hwang, I., Ku, K. B., Lee, S., Kim, S., & Kim, C. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2006.06006 · Cited by 37
Resistance to Rhabdoviridae Infection and Subversion of Antiviral Responses
Blondel, D., Maarifi, G., Nisole, S., & Chelbi‐Alix, M. K. (2015) · Viruses · doi:10.3390/v7072794 · Cited by 33
Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation
Menzel, M., Akbarshahi, H., Tufvesson, E., Persson, C. G. A., Bjermer, L. H., & Uller, L. (2017) · Oncotarget · doi:10.18632/oncotarget.16364 · Cited by 29
Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses
Verhelst, J., Spitaels, J., Hörner, C., Vlieger, D. D., Ysenbaert, T., Staeheli, P., Fiers, W. C., & Saelens, X. (2015) · Journal of Virology · doi:10.1128/jvi.01744-15 · Cited by 29
Subcellular proteomic analysis of human host cells infected with H3N2 swine influenza virus
Wu, X., Wang, S., Yu, Y., Zhang, J., Sun, Z., Yan, Y., & Zhou, J. (2013) · PROTEOMICS · doi:10.1002/pmic.201300180 · Cited by 29
Herpes Simplex Virus Type 1–Induced Transcriptional Networks of Corneal Endothelial Cells Indicate Antigen Presentation Function
Miyazaki, D., Haruki, T., Takeda, S., Sasaki, S.-I., Yakura, K., Terasaka, Y., Komatsu, N., Yamagami, S., Touge, H., Touge, C., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6911 · Cited by 29
Mx1 of black carp functions importantly in the antiviral innate immune response
Xiao, J., Yan, J., Chen, H., Li, J., Tian, Y., Tang, L., & Feng, H. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.10.002 · Cited by 31
Gene expression profiles in Finnish twins with multiple sclerosis
Särkijärvi, S., Kuusisto, H., Paalavuo, R., Levula, M., Airla, N., Lehtimäki, T. J., Kaprio, J. A., Koskenvuo, M., & Elovaara, I. (2006) · BMC Medical Genetics · doi:10.1186/1471-2350-7-11 · Cited by 29
Characterization of Atlantic halibut (Hippoglossus hippoglossus) Mx protein expression
Bergan, V., & Robertsen, B. (2004) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2004.03.003 · Cited by 29
Ovine Fetal Immune Response to Cache Valley Virus Infection
Hoffmann, A. R., Dorniak, P. L., Filant, J., Dunlap, K. A., Bazer, F. W., de la Concha-Bermejillo, A., Welsh, C. J., Varner, P., & Edwards, J. F. (2013) · Journal of Virology · doi:10.1128/jvi.01821-12 · Cited by 28
Molecular cloning, GTP recognition mechanism and tissue-specific expression profiling of myxovirus resistance (Mx) protein in Labeo rohita (Hamilton) after Poly I:C induction
Das, B. K., Roy, P., Rout, A. K., Sahoo, D. R., Panda, S. P., Pattanaik, S., Dehury, B., Behera, B. K., & Mishra, S. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40323-0 · Cited by 27
Interferon-Induced Expression of MxA in the Respiratory Tract of Rhesus Macaques Is Suppressed by Influenza Virus Replication
Carroll, T. D., Matzinger, S. R., Genescà, M., Fritts, L., Colón, R., McChesney, M. B., & Miller, C. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2385 · Cited by 27
The anti-viral dynamin family member MxB participates in mitochondrial integrity
Cao, H., Krueger, E. W., Chen, J., Drizyte-Miller, K., Schulz, M. E., & McNiven, M. A. (2020) · Nature Communications · doi:10.1038/s41467-020-14727-w · Cited by 25
MxA is a positive regulator of type I IFN signaling in HCV infection
Shi, X., Jiao, B., Chen, Y., Li, S., & Chen, L. (2017) · Journal of Medical Virology · doi:10.1002/jmv.24867 · Cited by 26
Exogenous IFN-alpha Administration Reduces Influenza A Virus Replication in the Lower Respiratory Tract of Rhesus Macaques
Matzinger, S. R., Carroll, T. D., Fritts, L., McChesney, M. B., & Miller, C. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029255 · Cited by 28
GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus
Yu, Z., Wang, Z., Chen, J., Li, H., Lin, Z., Zhang, F., Zhou, Y., & Hou, J. (2008) · Archives of Virology · doi:10.1007/s00705-008-0168-9 · Cited by 26
Tissue and time specific expression pattern of interferon regulated genes in the chicken
Röll, S., Härtle, S., Lütteke, T., Kaspers, B., & Härtle, S. (2017) · BMC Genomics · doi:10.1186/s12864-017-3641-6 · Cited by 27
Pathogenesis of idiopathic inflammatory myopathies
Grundtman, C., & Lundberg, I. E. (2006) · Current Rheumatology Reports · doi:10.1007/s11926-996-0024-4 · Cited by 26
In vitro inhibition of vesicular stomatitis virus replication by purified porcine Mx1 protein fused to HIV-1 Tat protein transduction domain (PTD)
Zhang, X., He, D., Zhou, B., Pang, R., Liu, K., Zhao, J., & Chen, P. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.05.009 · Cited by 25
MxA interacts with and is modified by the SUMOylation machinery
Brantis-de-Carvalho, C. E., Maarifi, G., Boldrin, P. E. G., Zanelli, C. F., Nisole, S., Chelbi‐Alix, M. K., & Valentini, S. R. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.10.020 · Cited by 26
Interferon, restriction factors and SUMO pathways
Asmi, F. E., McManus, F. P., Thibault, P., & Chelbi‐Alix, M. K. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.03.001 · Cited by 25
Long-term pegylated interferon-α and its potential in the treatment of melanoma
Dummer, R., & Mangana, J. (2009) · Biologics · doi:10.2147/btt.2009.3051 · Cited by 25
Nrf2 Expression Modifies Influenza A Entry And Replication In Nasal Epithelial Cells
Kesic, M. J., Simmons, S. O., & Jaspers, I. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2742 · Cited by 25
Human MxA protein inhibits the replication of classical swine fever virus
Zhao, Y., Pang, D., Wang, T., Yang, X., Wu, R., Ren, L., Yuan, T., Huang, Y., & Ouyang, H. (2011) · Virus Research · doi:10.1016/j.virusres.2011.01.008 · Cited by 24
DNA vaccine-mediated innate immune response triggered by PRRs in teleosts
Aoki, T., Takano, T., & Hikima, J.-I. (2015) · Fisheries Science · doi:10.1007/s12562-014-0845-4 · Cited by 24
MxA Induction May Predict Sustained Virologic Responses of Chronic Hepatitis B Patients with IFN- α Treatment
Kong, X., Zhang, X., Gong, Q., Gao, J. J., Zhang, S., Wang, L., Xu, J., Han, Y., Jin, G.-D., Jiang, J., et al. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.0163 · Cited by 24
Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers
Wang, Y., Brahmakshatriya, V., Lupiani, B., Reddy, S. M., Okimoto, R., Li, X., Chiang, H., & Zhou, H. (2012) · Poultry Science · doi:10.3382/ps.2012-02471 · Cited by 24
Deciphering psoriasis. A bioinformatic approach
Melero, J. L., Andrades, S., Arola, L., & Romeu, A. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.11.010 · Cited by 25
Intracellular Localization and Antiviral Property of Canine Mx Proteins
Nakamura, T., ASANO, A., Okano, S., Ko, J., Kon, Y., Watanabe, T., & Agui, T. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.169 · Cited by 24
Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631
Sasaki, K., Yoneda, A., Ninomiya, A., Kawahara, M., & Watanabe, T. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.053 · Cited by 24
Identification of Type I IFN in Chinese giant salamander (Andrias davidianus) and the response to an iridovirus infection
Chen, Q., Ma, J., Fan, Y., Meng, Y., Xu, J., Zhou, Y. K., Liu, W., Zeng, X., & Zeng, L. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.02.015 · Cited by 23
Mx gene diversity and influenza association among five wild dabbling duck species (Anas spp.) in Alaska
Dillon, D. M., & Runstadler, J. A. (2010) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2010.07.004 · Cited by 26
Dose- and Time-Dependent Apoptosis Induced by Avian H9N2 Influenza Virus in Human Cells
Shahsavandi, S., Ebrahimi, M. M., Sadeghi, K., Mosavi, S. Z., & Mohammadi, A. (2013) · BioMed Research International · doi:10.1155/2013/524165 · Cited by 23
Retracted
Immunoanalysis of antiviral Mx protein expression in Japanese flounder (Paralichthys olivaceus) cells
Ooi, E. L., Ohira, T., Hırono, I., Saito‐Taki, T., & Aoki, T. (2004) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2004.10.003 · Cited by 23
Potential of Interleukin (IL)-12 Group as Antivirals: Severe Viral Disease Prevention and Management
Rahman, N. A. A., Balasubramaniam, V. R. M. T., & Yap, W. B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087350 · Cited by 30
Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories
Gruenheid, S., & Gros, P. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04249.x · Cited by 22
CARD6 Is Interferon Inducible but Not Involved in Nucleotide-Binding Oligomerization Domain Protein Signaling Leading to NF-κB Activation
Dufner, A., Duncan, G. S., Wakeham, A. C., Elford, A. R., Hall, H. T. L., Ohashi, P. S., & Mak, T. W. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01359-07 · Cited by 22
Microarray technology is an effective tool for identifying genes related to the aquacultural improvement of Japanese flounder, Paralichthys olivaceus
Aoki, T., Hırono, I., Kondo, H., Hikima, J.-I., & Jung, T. S. (2010) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2010.06.005 · Cited by 21
Role of biomarkers in the diagnosis and prognosis of patients with cutaneous lupus erythematosus
Zhu, J. L., Black, S. M., & Chong, B. F. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5232 · Cited by 21
In vitro inhibition of sole aquabirnavirus by Senegalese sole Mx
Fernández-Trujillo, M. A., García‐Rosado, E., Alonso, M. C., Borrego, J. J., Álvarez, M. C., & Béjar, J. (2007) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2007.10.010 · Cited by 20
A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection
Zou, R., Zhang, G., Shao-yuan, L., Wang, W., Yuan, J., Li, J., Wang, Y., Lin, Y., Deng, Y., Zhou, B., et al. (2015) · Scientific Reports · doi:10.1038/srep18541 · Cited by 20
MxA expression as marker for assessing the therapeutic response in HCV genotype 4 Egyptian patients
Shaker, O. G., Ahmed, A., Doss, W. H., & Abdel-Hamid, M. (2009) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2009.01241.x · Cited by 20
Mx Is Not Responsible for the Antiviral Activity of Interferon-α against Japanese Encephalitis Virus
Zhou, J., Wang, S., Wei, J., Zhang, X.-M., Gao, Z.-C., Liu, K., Ma, Z., Chen, P., & Zhou, B. (2017) · Viruses · doi:10.3390/v9010005 · Cited by 20
Epitope-Based Immunoinformatics and Molecular Docking Studies of Nucleocapsid Protein and Ovarian Tumor Domain of Crimean?Congo Hemorrhagic Fever Virus
Srinivasan, P., Kumar, S. P., Muthusamy, K., Jeyakanthan, J., Jasrai, Y. T., Pandya, H., Rawal, R., & Patel, S. (2011) · Frontiers in Genetics · doi:10.3389/fgene.2011.00072 · Cited by 19
Induction of anti-viral genes during acute infection with Viral hemorrhagic septicemia virus (VHSV) genogroup IVa in Pacific herring (Clupea pallasii)
Hansen, J. D., Woodson, J. C., Hershberger, P. K., Grady, C. A., Gregg, J. L., & Purcell, M. K. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2011.11.010 · Cited by 19
Human gammaherpesvirus immune evasion strategies
Means, R. E., Lang, S. M., & Jung, J. U. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545313.032 · Cited by 20
Interferon α–Induced Inhibition of Infectious Bursal Disease Virus in Chicken Embryo Fibroblast Cultures Differing inMxGenotype
O’Neill, A. M., Livant, E. J., & Ewald, S. J. (2010) · Avian Diseases · doi:10.1637/9001-072309-reg.1 · Cited by 19
Conventional Protein Kinase C Inhibition Prevents Alpha Interferon-Mediated Hepatitis C Virus Replicon Clearance by Impairing STAT Activation
Fimia, G. M., Evangelisti, C., Alonzi, T., Romani, M., Fratini, F., Paonessa, G., Ippolito, G., Tripodi, M., & Piacentini, M. (2004) · Journal of Virology · doi:10.1128/jvi.78.23.12809-12816.2004 · Cited by 19
Implication of innate immunity in the pathogenesis of biliary atresia.
Chuang, J., Chou, M.-H., Wu, C.-L., & Du, Y.-Y. (2006) · PubMed · Cited by 19
Influenza Pathogenesis in Genetically Defined Resistant and Susceptible Murine Strains .
Samet, S., & Tompkins, S. M. (2017) · Europe PMC (PubMed Central) · Cited by 19
Infectious Bronchitis Virus 3a Protein Localizes to a Novel Domain of the Smooth Endoplasmic Reticulum
Pendleton, A. R., & Machamer, C. E. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.6142-6151.2005 · Cited by 20
Immunohistochemical Evaluation of Mx Protein Expression in Canine Encephalitides
Porter, B. F., Ambrus, A., & Storts, R. W. (2006) · Veterinary Pathology · doi:10.1354/vp.43-6-981 · Cited by 19
Virus usurps alternative splicing to clear the decks for infection
Li, R., Gao, S., Chen, H., Zhang, X., Yang, X., Zhao, J., & Wang, Z. (2023) · Virology Journal · doi:10.1186/s12985-023-02098-9 · Cited by 18
Tobacco Mosaic Virus – a Model for Macromolecular Cell-to-Cell Spread
Waigmann, E., Curin, M., & Heinlein, M. (2007) · Springer eBooks · doi:10.1007/7089_2006_100 · Cited by 18
Cellular Localization and Function of the Antiviral Protein, Ovine Mx1 (oMx1): II. The oMx1 Protein Is a Regulator of Secretion in an Ovine Glandular Epithelial Cell Line
Toyokawa, K., Leite, F. P. L., & OTT, T. L. (2006) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00439.x · Cited by 18
Organic Selenium (OH-MetSe) Effect on Whole Body Fatty Acids and Mx Gene Expression against Viral Infection in Gilthead Seabream (Sparus aurata) Juveniles
Tseng, Y., Domínguez, D., Bravo, J., Acosta, F., Robaina, L., Geraert, P., Kaushik, S., & Izquierdo, M. S. (2021) · Animals · doi:10.3390/ani11102877 · Cited by 18
Comparison of mono- and co-infection by swine influenza A viruses and porcine respiratory coronavirus in porcine precision-cut lung slices
Krimmling, T., & Schwegmann‐Weßels, C. (2017) · Research in Veterinary Science · doi:10.1016/j.rvsc.2017.07.016 · Cited by 18
Interferon-Stimulated Genes Response in Endothelial Cells Following Hantaan Virus Infection
Kim, I.-W., Hwang, J. Y., Kim, S.-K., Kim, J.-K., & Park, H.-S. (2007) · Journal of Korean Medical Science · doi:10.3346/jkms.2007.22.6.987 · Cited by 18
A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus
Sasaki, K., Tungtrakoolsub, P., Morozumi, T., Uenishi, H., Kawahara, M., & Watanabe, T. (2013) · Immunogenetics · doi:10.1007/s00251-013-0745-2 · Cited by 17
HCV Replicon Systems
Blight, K. J., & Norgard, E. A. (2006) · Europe PMC (PubMed Central) · Cited by 17
Induction of Interferon Synthesis by the PKR-Inhibitory VA RNAs of Adenoviruses
Weber, F., Wagner, V., Kessler, N., & Haller, O. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.1 · Cited by 17
Self-citation
Porcine Mx1 fused to HIV Tat protein transduction domain (PTD) inhibits classical swine fever virus infection in vitro and in vivo
Zhang, X., Jing, J., Li, W., Liu, K., Shi, B., Xu, Q., Ma, Z., Zhou, B., & Chen, P. (2015) · BMC Veterinary Research · doi:10.1186/s12917-015-0577-4 · Cited by 17
Inhibition of interferon-α-induced signaling by hyperosmolarity and hydrophobic bile acids
Graf, D., Haselow, K., Münks, I., Bode, J. G., & Häussinger, D. (2010) · Biological Chemistry · doi:10.1515/bc.2010.108 · Cited by 17
Purifying selection and positive selection on the myxovirus resistance gene in mammals and chickens
Hou, Z., Xu, G., Su, Z., & Yang, N. (2007) · Gene · doi:10.1016/j.gene.2007.03.017 · Cited by 19
Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis
Xing, C., Trivedi, J. R., Bitencourt, N., Burns, D. K., REISCH, J. S., & Cai, C. (2024) · Muscle & Nerve · doi:10.1002/mus.28066 · Cited by 16
Dietary curcumin supplementation enhances intestinal immunity and gill protection in juvenile greater amberjack (Seriola dumerili)
He, Y., Fu, Z., Dai, S., Yu, G., Ma, Z., & Wang, X. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11887 · Cited by 16
High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response
Burkart, S. S., Schweinoch, D., Frankish, J., Sparn, C., Wüst, S., Urban, C., Merlo, M., Magalhães, V. G., Piras, A., Pichlmair, A., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302059 · Cited by 18
Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: Novel antiviral activity against VSV
Sehgal, P. B., Yuan, H., Scott, M. F., Deng, Y., Liang, F., & Mackiewicz, A. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015661 · Cited by 16
Self-protection and survival of arbovirus-infected mosquito cells
López-Montero, N., & Risco, C. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01536.x · Cited by 15
Expression of the antiviral protein MxA in cells transiently perturbs endocytosis
Jatiani, S., & Mittal, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.134 · Cited by 16
Proteomic and transcriptomic characterization of interferon‐α‐induced human primary T helper cells
Rosengren, A. T., Nyman, T. A., Syyrakki, S., Matikainen, S., & Lahesmaa, R. (2005) · PROTEOMICS · doi:10.1002/pmic.200400967 · Cited by 16
Orthomyxoviruses: Influenza
Cox, N. J., Neumann, G., Donis, R. O., & Kawaoka, Y. (2010) · Wiley eBooks · doi:10.1002/9780470688618.taw0238 · Cited by 16

Authors: Haller, O., & Kochs, G.
Affiliations: University of Freiburg (DE)
Corresponding author: Haller, Otto
ORCID: Haller, Otto
Kochs, Georg
Venue: Traffic
Publisher: Wiley
Published: 2002-09-16
Volume: 3
Issue: 10
Pages: 710-717
ISSN: 1398-9219 (ISSN-L)
1600-0854
DOI: 10.1034/j.1600-0854.2002.31003.x
OpenAlex: W2090023448
Cited by: 460
References: 53
Citations by year: 2026: 2 · 2025: 10 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 9 · 2020: 15 · 2019: 8 · 2018: 11 · 2017: 14 · 2016: 8 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 23
FWCI: 2.41
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Traffic (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: Mx protein, MxA, dynamin superfamily, antiviral activity, Bunyaviridae, orthomyxoviruses, Thogoto virus, Golgi apparatus, endoplasmic reticulum, GTP hydrolysis, viral assembly, RNA viruses, host-virus interaction
MeSH terms: Antiviral Agents, Interferons, Molecular Weight, Subcellular Fractions, GTP-Binding Proteins, GTP Phosphohydrolases, Dynamins, Myxovirus Resistance Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks