The role of the hippocampus in memory for the temporal order of a sequence of odors.

Abstract

Memory for the temporal order of a sequence of odors was assessed in rats. A sequence of 5 odors mixed in sand was presented in digging cups, 1 at a time, to each rat in a sequence that varied on each trial. A reward was buried in each cup. After the 5th odor, 2 of the previous 5 odors were presented simultaneously; to receive a reward, the rat had to choose the odor that occurred earliest in the sequence. Temporal separations of 1, 2, or 3 represented the number of odors that occurred between the 2 odors in the sequence. Once a preoperative criterion was reached, each rat received a hippocampal (HIP) or cortical control lesion and was retested on the task. On postoperative trials, the HIP group was impaired relative to controls. However, the HIP group could discriminate between the odors. The data suggest that the hippocampus is involved in separating sensory events in time so that I event can be remembered separately from another event.

Cites (25)

1. The Rat Brain in Stereotaxic Coordinates
   1982 · Elsevier eBooks
2. Untitled work
   1978 · UA Campus Repository (The University of Arizona)
3. A cortical–hippocampal system for declarative memory
   Eichenbaum, Howard · 2000 · Nature Reviews Neuroscience
4. The Neurobiology of Learning and Memory
   Thompson, Richard F. · 1986 · Science
5. Hippocampectomy disrupts trace eye-blink conditioning in rabbits.
   Moyer, James R., Deyo, Richard A., Disterhoft, John F. · 2015 · Behavioral Neuroscience
6. Hippocampectomy disrupts trace eye-blink conditioning in rabbits.
   Moyer, James R., Deyo, Richard A., Disterhoft, John F. · 1990 · Behavioral Neuroscience
7. Associations across time: The hippocampus as a temporary memory store
   Rawlins, J. N. P. · 1985 · Behavioral and Brain Sciences
8. A theory of hippocampal function in memory
   Rolls, Edmund T. · 1996 · Hippocampus
9. Hippocampus, time, and memory.
   Meck, Warren H., Church, Russell M., Olton, David S. · 2013 · Behavioral Neuroscience
10. Complementary roles of the orbital prefrontal cortex and the perirhinal-entorhinal cortices in an odor-guided delayed-nonmatching-to-sample task.
    Otto, Tim, Eichenbaum, Howard · 1992 · Behavioral Neuroscience

Show all 25 references

Cited by (40)

1. Regional dissociations within the hippocampus-memory and anxiety
   Bannerman, D.M, Rawlins, J.N.P, McHugh, S.B, Deacon, R.M.J, Yee, B.K, Bast, T, Zhang, W.-N, Pothuizen, H.H.J, Feldon, J · 2004 · Neuroscience & Biobehavioral Reviews
2. Untitled work
   Eichenbaum · 2004 · 10.1016/j.neuron.2004.08.028
3. Memory of sequential experience in the hippocampus during slow wave sleep
   Lee, Albert K., Wilson, Matthew A. · 2002 · Neuron
4. Hippocampal ‘time cells’ bridge the gap in memory for discontiguous events
   MacDonald, Christopher J., Lepage, Kyle Q., Eden, Uri T., Eichenbaum, Howard · 2011 · Neuron
5. The anatomy of memory: an interactive overview of the parahippocampal–hippocampal network
   van Strien, N. M., Cappaert, N. L. M., Witter, M. P. · 2009 · Nature Reviews Neuroscience

See all 309