Differences in the functional neuroanatomy of inhibitory control across the adult life span.

Abstract

Inhibitory control, the ability to suppress irrelevant or interfering stimuli, is a fundamental cognitive function that deteriorates during aging, but little is understood about the bases of decline. Thus, we used event-related functional magnetic resonance imaging (fMRI) to study inhibitory control in healthy adults aged 18 to 78. Activation during "successful inhibition" occurred predominantly in right prefrontal and parietal regions and was more extensive, bilaterally and prefrontally, in the older groups. Presupplementary motor area was also more active in poorer inhibitory performers. Therefore, older adults activate areas that are comparable to those activated by young adults during inhibition, as well as additional regions. The results are consistent with a compensatory interpretation and extend the aging neuroimaging literature into the cognitive domain of inhibition.

Cites (114)

1. “Mini-mental state”
   Folstein, Marshal F., Folstein, Susan E., McHugh, Paul R. · 1975 · Journal of Psychiatric Research
2. The Unity and Diversity of Executive Functions and Their Contributions to Complex “Frontal Lobe” Tasks: A Latent Variable Analysis
   Miyake, Akira, Friedman, Naomi P., Emerson, Michael J., Witzki, Alexander H., Howerter, Amy, Wager, Tor D. · 2000 · Cognitive Psychology
3. Co-Planar Stereotaxic Atlas of the Human Brain
   Jean Talairach, P Tournoux · 1988 · Medical Entomology and Zoology
4. AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
   Cox, Robert W. · 1996 · Computers and Biomedical Research
5. Untitled work
   Sheikh · 1986 · 10.1300/j018v05n01_09
6. The processing-speed theory of adult age differences in cognition
   Salthouse, Timothy A. · 1996 · Psychological Review
7. Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
   Cabeza, Roberto, Nyberg, Lars · 2000 · Journal of Cognitive Neuroscience
8. Working memory, comprehension, and aging: A review and a new view
   Hasher, Lynn, Zacks, Rose T. · 1988 · Psychology of Learning and Motivation
9. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold
   Forman, Steven D., Cohen, Jonathan D., Fitzgerald, Mark, Eddy, William F., Mintun, Mark A., Noll, Douglas C. · 1995 · Magnetic Resonance in Medicine
10. Untitled work
    1995

Show all 114 references

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