Cognitive-behavioral analysis system of psychotherapy as a maintenance treatment for chronic depression
Abstract
Although the efficacy of maintenance pharmacotherapy for the prevention of recurrence in major depressive disorder (MDD) is well documented, few studies have tested the efficacy of psychotherapy as a maintenance treatment. The authors examined the efficacy of the cognitive-behavioral analysis system of psychotherapy (CBASP) as a maintenance treatment for chronic forms of MDD. Eighty-two patients who had responded to acute and continuation phase CBASP were randomized to monthly CBASP or assessment only for 1 year. Significantly fewer patients in the CBASP than assessment only condition experienced a recurrence. The 2 conditions also differed significantly on change in depressive symptoms over time. These findings support the use of CBASP as a maintenance treatment for chronic forms of MDD.
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The study utilized a dual-criterion threshold for determining clinical relapse (SCID and HRSD), which prioritizes confidence in relapse events at the expense of excluding partial relapse phenomena.
“Second, we utilized a dual-criterion threshold for determining clinical relapse (SCID and HRSD); while commonly used (Klein et al., 2004, Reynolds et al., 2006), this approach prioritizes confidence in relapse events at the expense of excluding partial relapse phenomena.”
From Static and treatment-responsive brain biomarkers of depression relapse vulnerability following prophylactic psychotherapy: Evidence from a randomized control trial (2022) · cites this paper as Klein et al., 2004
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- Authors
- Klein, D. N., Santiago, N. J., Vivian, D., Blalock, J. A., Kocsis, J. H., Markowitz, J. C., McCullough, J. P., Rush, A. J., Trivedi, M. H., Arnow, B. A., Dunner, D. L., Manber, R., Rothbaum, B., Thase, M. E., Keitner, G. I., Miller, I. W., & Keller, M. B.
- Affiliations
- State University of New York (US)
- Stony Brook University (US)
- The University of Texas Medical Branch at Galveston (US)
- Cornell University (US)
- Virginia Commonwealth University (US)
- The University of Texas Southwestern Medical Center (US)
- Stanford Medicine (US)
- University of Arizona (US)
- Emory University (US)
- University of Pittsburgh Medical Center (US)
- Brown University (US)
- ORCID
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2004
- Volume
- 72
- Issue
- 4
- Pages
- 681-688
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- OpenAlex
- W2083325602
- Cited by
- 138
- References
- 4
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 16 · 2012: 11
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (U01MH061590)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- CBASP, maintenance therapy, chronic depression, major depressive disorder, depression recurrence prevention, psychotherapy, depressive symptoms
- MeSH terms
- Adolescent, Adult, Aged, Chronic Disease, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Middle Aged, Cognitive Behavioral Therapy, Diagnostic and Statistical Manual of Mental Disorders
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