Cited by 98Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychological Treatments and Disorders

Chronic depression: update on classification and treatment

Torpey, Dana C., Klein, Daniel N.·2008·Current Psychiatry Reports

Abstract

A significant proportion of patients with depressive disorders suffer from chronic conditions. The DSM-IV recognizes several forms of chronic depression. Chronic depressions differ from nonchronic major depressive disorder (MDD) on many clinical, psychosocial, and familial variables. However, less support exists for current distinctions between the various forms of chronic depression. Antidepressant medications and at least some forms of psychotherapy are efficacious in treating chronic depression, and the combination of pharmacotherapy and psychotherapy appears to be superior to either monotherapy alone. Still, chronic depression is often inadequately treated, and many patients fail to respond or continue to experience residual symptoms after treatment. An important direction for future research is to elucidate the multiple pathways to chronic depression and to tailor treatments to specific etiopathogenetic subgroups.

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Crossref · 10.1007/s11920-008-0074-6

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47 of 47 references verified0 citation errors · 0 not checkable

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  • Clinical studies indicate that a substantial proportion of people who seek treatment for major depression have a chronic-recurrent course.

    “clinical studies show that a substantial proportion of people who seek treatment for major depression have a chronic-recurrent course of illness.13, 14”

    From The Costs of Depression (2012) · cites this paper as [14]

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Authors
Torpey, D. C., & Klein, D. N.
Affiliations
Stony Brook University (US)
Corresponding author
Klein, Daniel N.
Venue
Current Psychiatry Reports
Published
2008-12
Volume
10
Issue
6
Pages
458-464
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
OpenAlex
W2025400419
Cited by
98
References
47
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 12 · 2015: 7 · 2014: 14 · 2013: 7 · 2012: 3
FWCI
0.57
Type
journal article
Language
en
Open access
closed
Locations
  • Current Psychiatry Reports (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH045757)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Keywords
chronic depression, dysthymia, major depressive disorder, depression classification, antidepressant treatment, psychotherapy, treatment-resistant depression, residual depressive symptoms
MeSH terms
Antidepressive Agents, Chronic Disease, Combined Modality Therapy, Major Depressive Disorder, Depressive Disorder, Major, Diagnosis, Differential, Humans, Psychotherapy, Recurrence, Self Care, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Dysthymic Disorder, Diagnostic and Statistical Manual of Mental Disorders

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