Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers
Abstract
Adolescent smokers (N = 211) were randomized to 1 of 2 groups: (a) nicotine patch plus bupropion SR (sustained release; 150 mg per day) or (b) nicotine patch plus placebo. Group skills training sessions were conducted each week by research staff. Abstinence rates at Weeks 10 and 26 were as follows: (a) patch plus bupropion, 23% and 8%, (b) patch plus placebo, 28% and 7%. Despite the lack of a treatment effect, a large majority of adolescents in both treatment groups reduced their consumption to a few cigarettes per day or less and maintained this reduction over time. Similarly, an examination of survival curves revealed that by the end of treatment many had managed to avoid a return to daily smoking. These findings are encouraging and suggest new avenues for research. For example, treatments of the kind examined in this report, augmented by extended maintenance therapies, may yield higher long-term success rates.
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A combination of nortriptyline and nicotine patch resulted in higher success rate compared to nicotine patch alone (23% vs 10% at 6 months).
“A combination of nortriptyline and nicotine patch resulted in higher success rate compared to the nicotine patch alone (23% vs. 10% at 6 months; 112)”
From Tobacco addiction (2008) · cites this paper as [112]
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- Authors
- Killen, J. D., Robinson, T. N., Ammerman, S., Hayward, C., Rogers, J., Stone, C., Samuels, D., Levin, S. K., Green, S., & Schatzberg, A. F.
- Affiliations
- Stanford Medicine (US)
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2004
- Volume
- 72
- Issue
- 4
- Pages
- 729-735
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- OpenAlex
- W2170062274
- Cited by
- 146
- References
- 18
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 11 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 10 · 2014: 7 · 2013: 8 · 2012: 8
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca080268-04)
- National Cancer Institute (CA80268)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- adolescent smoking, bupropion, nicotine patch, smoking cessation, nicotine replacement therapy, bupropion sustained release, abstinence rates, smoking reduction, skills training, maintenance therapy
- MeSH terms
- Smoking Prevention, Administration, Cutaneous, Adolescent, Drug Therapy, Combination, Female, Humans, Male, Nicotine, Tobacco Use Disorder, Smoking Cessation, Bupropion, Dopamine Uptake Inhibitors
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