The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Normally occurring environmental and behavioral influences on gene activity: From central dogma to probabilistic epigenesis
Abstract
The central dogma of molecular biology holds that "information" flows from the genes to the structure of the proteins that the genes bring about through the formula DNA-->RNA-->Protein. In this view, a set of master genes activates the DNA necessary to produce the appropriate proteins that the organism needs during development. In contrast to this view, probabilistic epigenesis holds that necessarily there are signals from the internal and external environment that activate DNA to produce the appropriate proteins. To support this view, a substantial body of evidence is reviewed showing that external environmental influences on gene activation are normally occurring events in a large variety of organisms, including humans. This demonstrates how genes and environments work together to produce functional organisms, thus extending the author's model of probabilistic epigenesis.
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Metadata
- Authors
- Gottlieb, G.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Gottlieb, Gilbert
- Venue
- Psychological Review
- Published
- 1998
- Volume
- 105
- Issue
- 4
- Pages
- 792-802
- ISSN
- 0033-295X (ISSN-L)
- 1939-1471
- OpenAlex
- W2018492820
- Cited by
- 489
- References
- 85
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 12 · 2023: 20 · 2022: 13 · 2021: 7 · 2020: 40 · 2019: 11 · 2018: 11 · 2017: 23 · 2016: 11 · 2015: 28 · 2014: 20 · 2013: 30 · 2012: 20
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Review (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-52429, P50MH052429)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- central dogma, gene-environment interaction, environmental influences on gene expression, epigenetic regulation, organismal development
- MeSH terms
- Behavior, DNA, Environment, Humans, RNA, Messenger, Twins
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