Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene.

Abstract

This study evaluated whether there are genetic subgroups of depressed individuals who are more or less predisposed to engage in self-medication smoking practices. Smokers (N = 231) completed self-report questionnaires of depression and smoking practices and were genotyped for the dopamine D4 receptor (DRD4) gene. A significant interaction (DRD4 Genotype x Depression) was found for stimulation smoking and negative-affect reduction smoking. Specifically, these smoking practices were significantly heightened in depressed smokers homozygous for the short alleles of DRD4 but not in those heterozygous or homozygous for the long alleles of DRD4. These preliminary results suggest that the rewarding effects of smoking and the beneficial effects of nicotine replacement therapy for depressed smokers may depend, in part, on genetic factors involved in dopamine transmission.

Cites (43)

1. Diagnostic and Statistical Manual of Mental Disorders
   Williams, Janet B. W., First, Michael · 2013 · Encyclopedia of Social Work
2. The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
   Radloff, Lenore Sawyer · 1977 · Applied Psychological Measurement
3. The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
   HEATHERTON, TODD F., KOZLOWSKI, LYNN T., FRECKER, RICHARD C., FAGERSTROM, KARL‐OLOV · 1991 · British Journal of Addiction
4. Diagnostic and Statistical Manual of Mental Disorders (3rd ed. rev.)
   Drake, Margaret · 1988 · The American Journal of Occupational Therapy
5. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
   Lesch, Klaus-Peter, Bengel, Dietmar, Heils, Armin, Sabol, Sue Z., Greenberg, Benjamin D., Petri, Susanne, Benjamin, Jonathan, Müller, Clemens R., Hamer, Dean H., Murphy, Dennis L. · 1996 · Science
6. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
   Di Chiara, G, Imperato, A · 1988 · Proceedings of the National Academy of Sciences
7. Psychopharmacology: The Fourth Generation of Progress
   Floyd E. Bloom, David J. Kupfer · 1995 · Medical Entomology and Zoology
8. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
   Van Tol, Hubert H. M., Bunzow, James R., Guan, Hong-Chang, Sunahara, Roger K., Seeman, Philip, Niznik, Hyman B., Civelli, Olivier · 1991 · Nature
9. Brain Dopamine and Reward
   Wise, R. A., Rompre, P.-P. · 1989 · Annual Review of Psychology
10. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
    Ebstein, Richard P., Novick, Olga, Umansky, Roberto, Priel, Beatrice, Osher, Yamima, Blaine, Darren, Bennett, Estelle R., Nemanov, Lubov, Katz, Miri, Belmaker, Robert H. · 1996 · Nature Genetics

Show all 43 references

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2. Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report
   Ziedonis, D., Hitsman, B., Beckham, J. C., Zvolensky, M., Adler, L. E., Audrain-McGovern, J., Breslau, N., Brown, R. A., George, T. P., Williams, J. et al. · 2008 · Nicotine & Tobacco Research
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   Kalman, David, Morissette, Sandra Baker, George, Tony P. · 2005 · The American Journal on Addictions
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   Boden, Joseph M., Fergusson, David M., Horwood, L. John · 2010 · British Journal of Psychiatry
5. It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
   PICCIOTTO, M, ADDY, N, MINEUR, Y, BRUNZELL, D · 2008 · Progress in Neurobiology

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