The DOI matches its Crossref record.
What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?
Abstract
Because electrical stimulation of the lateral hypothalamus (ESLH) can elicit both feeding and reward, most investigators have concluded that stimulation does not evoke the aversive cues associated with hunger. It has been hypothesized, instead, that ESLH primes ingestion by evoking pleasurable taste sensations. A direct taste of this hedonic hypothesis was undertaken in rats that showed stimulus-bound feeding. Contrary to the prediction, it was found that the taste reactions (gapes, tongue protrusions, etc.) during ESLH were more aversive than hedonic. It is suggested that the stimulation influences behavior by potentiating the salience, but not the hedonic value, of external stimuli. The advantages of this incentive salience hypothesis are that it circumvents the need to postulate a hedonic sensory experience during stimulation and that it can explain how evoked feeding may switch to other behaviors when conditions are altered.
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“Although it was long believed that dopamine was the neurotransmitter responsible for pleasure, this has long been disproved, and a large body of evidence suggests that it instead modulates ‘wanting’ (Berridge & Valenstein, 1991; Peciña, Cagniard, Berridge, Aldridge, & Zhuang, 2003; Tindell, Berridge, Zhang, Peciña, & Aldridge, 2005; Wyvell & Berridge, 2000).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Berridge & Valenstein, 1991
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The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Self-citationThe debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347
“" (Berridge and Valenstein 1991, p. 9) and " In other words, dopamine systems are necessary for 'wanting' incentives, but not for 'liking' them or for learning new 'likes' and 'dislikes' (Berridge and Robinson 1998, p. 309).”
BackgroundMethodInfluentialSelf-citationFood reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901
“My colleagues and I have suggested that the primary motivational role of such systems is to attribute incentive salience to selected percepts and representations (13,15,16,106).”
BackgroundSelf-citationBerridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730
“However, contrary to that tastier food hypothesis, Berridge and Valenstein found that LH stimulation failed to enhance ''liking'' reactions to sweetness, even though it made the rats ''want'' to eat at least four times more than normal amounts (Berridge and Valenstein, 1991).”
ResultSelf-citation
Metadata
- Authors
- Berridge, K. C., & Valenstein, E. S.
- Affiliations
- University of Michigan (US)
- ORCID
- Berridge, Kent C.
- Venue
- Behavioral Neuroscience
- Published
- 1991
- Volume
- 105
- Issue
- 1
- Pages
- 3-14
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2139823869
- Cited by
- 302
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 20 · 2022: 4 · 2021: 4 · 2020: 52 · 2019: 45 · 2018: 9 · 2017: 4 · 2016: 12 · 2015: 14 · 2014: 11 · 2013: 6 · 2012: 6
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-23959, R01NS023959)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- lateral hypothalamus, electrical stimulation, incentive salience, hunger, reward
- MeSH terms
- Animals, Appetite, Arousal, Avoidance Learning, Brain Mapping, Brain Stem, Dopamine, Electric Stimulation, Feeding Behavior, Hypothalamic Area, Lateral, Male, Motivation, Motor Activity, Neural Pathways, Neurons, Taste, Rats
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