The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Differential effects of the N-methyl-d-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues
Abstract
Intracerebroventricular (icv) administration of the N-methyl-D-aspartate receptor (NMDA) antagonist DL-2-amino-5-phosphonovalerate (APV) before tone-shock pairings caused a dose-dependent suppression of acquisition of fear of contextual cues associated with shock. Acquisition of fear of the tone was not impaired. Experiment 2 showed that the fear of the tone was associative and that this tone-shock association was less affected by APV than was a context-shock association. Rats receiving APV before context-shock pairings showed an equivalent loss of fear regardless of whether testing occurred 1 or 28 days after training. It appears that icv administration of APV blocks acquisition of context conditioning by affecting NMDA receptors in the hippocampus. Activity at these receptors at the time of acquisition seems critical for later expression of both intermediate (1 day to 2 weeks) and remote (4 weeks) fear memories.
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“In addition, the finding that withdrawal disrupted contextual but not cued fear conditioning adds to a growing literature that, at least in the mouse model, nicotine withdrawal disrupts hippocampus-dependent learning but not hippocampus-independent learning as contextual fear conditioning requires the hippocampus whereas cued fear conditioning does not (Fanselow et al., 1994; Logue et al., 1997;”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Fanselow et al., 1994
In the citing paper
“In addition, the finding that withdrawal disrupted contextual but not cued fear conditioning adds to a growing literature that, at least in the mouse model, nicotine withdrawal disrupts hippocampus-dependent learning but not hippocampus-independent learning as contextual fear conditioning requires the hippocampus whereas cued fear conditioning does not (Fanselow et al., 1994; Logue et al., 1997;”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Fanselow et al., 1994
In the citing paper
“fear conditioning requires the hippocampus whereas cued fear conditioning does not (Fanselow et al., 1994; Logue et al., 1997; Phillips and Ledoux, 1992).”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Fanselow et al., 1994
Citations
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Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
Neurobiology of Pavlovian fear conditioning
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Regulation of histone acetylation during memory formation in the hippocampus
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New Vistas on Amygdala Networks in Conditioned Fear
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Metadata
- Authors
- Fanselow, M. S., Kim, J. J., Yipp, J., & De Oca, B.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Behavioral Neuroscience
- Published
- 1994
- Volume
- 108
- Issue
- 2
- Pages
- 235-240
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1969089790
- Cited by
- 142
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- NMDA receptor antagonism, fear conditioning, contextual fear, hippocampus, memory consolidation, remote memory, intracerebroventricular administration, associative learning
- MeSH terms
- Animals, Association Learning, Auditory Perception, Conditioning, Classical, Cues, Dose-Response Relationship, Drug, Electroshock, Fear, Female, Hippocampus, Memory, Short-Term, Motor Activity, Mental Recall, Retention, Psychology, Social Environment, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Rats
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